NICKEL

Details

Stereochemistry	ACHIRAL
Molecular Formula	Ni
Molecular Weight	58.6934
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Ni]

InChI

InChIKey=PXHVJJICTQNCMI-UHFFFAOYSA-N

InChI=1S/Ni

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Attempts to identify the causative allergen in cases of allergic contact dermatitis using an in vitro lymphocyte transformation test.	1990	20702182
An optimized lymphocyte blastogenesis assay for detecting the response of contact sensitized or photosensitized lymphocytes to hapten or photohapten modified antigen presenting cells.	1990	20702180
Use of an optimized in vitro lymphocyte blastogenesis assay to detect contact sensitivity to nickel sulfate in mice.	1990 Jun 1	1694310
Oxidative stress due to nickel toxicity in the liver of protein-deficient rats.	2005	20021064
LH release by Cu and Ni salts and metal-GnRH complexes, in vitro.	2006 Aug	16892001
Cytogenetic effects of a mixture of selected metals following subchronic exposure through drinking water in male rats.	2006 Dec	17176674
Nickel, cobalt, chromium, palladium and gold induce a mixed Th1- and Th2-type cytokine response in vitro in subjects with contact allergy to the respective metals.	2006 Dec	17100760
Activation of MAP kinases by hexavalent chromium, manganese and nickel in human lung epithelial cells.	2006 Dec 1	17045426
Effect of metal ions on HIF-1alpha and Fe homeostasis in human A549 cells.	2006 Nov 7	16877034
Ni(II) affects ubiquitination of core histones H2B and H2A.	2006 Oct 15	16870173
Allergic contact dermatitis to nickel: modified in vitro test protocols for better detection of allergen-specific response.	2007 Feb	17244072
Ni K-edge XAS suggests that coordination of Ni(II) to the unstructured amyloidogenic region of the human prion protein produces a Ni(2) bis-mu-hydroxo dimer.	2007 Feb	17126907
Antigen-driven HIV expansion in allergen-specific T cells.	2007 Jan	17263646
T-type Ca2+ channels mediate propagation of odor-induced Ca2+ transients in rat olfactory receptor neurons.	2007 Jan 19	17110049
Chemokine responses distinguish chemical-induced allergic from irritant skin inflammation: memory T cells make the difference.	2007 Jun	17337293
The contact allergen nickel triggers a unique inflammatory and proangiogenic gene expression pattern via activation of NF-kappaB and hypoxia-inducible factor-1alpha.	2007 Mar 1	17312168
Gene expression time course in the human skin during elicitation of allergic contact dermatitis.	2007 Nov	17597826
Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors.	2007 Sep	17916923
Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel.	2008 Dec 1	18835401
Release of nickel from coins and deposition onto skin from coin handling--comparing euro coins and SEK.	2008 Jul	18537991
Deposition of nickel, chromium, and cobalt on the skin in some occupations - assessment by acid wipe sampling.	2008 Jun	18503684
Efficacy of caffeic acid in preventing nickel induced oxidative damage in liver of rats.	2008 May 28	18405891
Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells.	2009 Apr	19440498
HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway.	2009 Feb	19033392
Comparison of gene expression profiles in HepG2 cells exposed to arsenic, cadmium, nickel, and three model carcinogens for investigating the mechanisms of metal carcinogenesis.	2009 Jan	19031421
Mechanisms of cytotoxicity of nickel ions based on gene expression profiles.	2009 Jan	18922574
Signal transducer and activator of transcription 1 (STAT1) is essential for chromium silencing of gene induction in human airway epithelial cells.	2009 Jul	19403854
Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells.	2009 Jul	19097988
Effect of short-time exposures to nickel and lead on brain monoamine oxidase from Danio rerio and Poecilia reticulata.	2009 Jun	18767136
Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells.	2009 Mar 16	18812211
Patch-test results of the North American Contact Dermatitis Group 2005-2006.	2009 May-Jun	19470301
Expression and functional characterization of four aquaporin water channels from the European eel (Anguilla anguilla).	2009 Sep 1	19684221
Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants.	2010 Aug 30	20600679
Exposure to inhaled nickel nanoparticles causes a reduction in number and function of bone marrow endothelial progenitor cells.	2010 Dec	20936915
Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells.	2010 Dec	20881000
From GC-rich DNA binding to the repression of survivin gene for quercetin nickel (II) complex: implications for cancer therapy.	2010 Dec	20577783
Oxidative damage effects in the copepod Tigriopus japonicus Mori experimentally exposed to nickel.	2010 Feb	19821026
Nickel induces intracellular calcium mobilization and pathophysiological responses in human cultured airway epithelial cells.	2010 Jan 5	19781536
Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model.	2010 Jan-Feb	19130878
Nickel sensitisation in mice: a critical appraisal.	2010 Jun	20456924
Comparative in situ topoproteome analysis reveals differences in patch test-induced eczema: cytotoxicity-dominated nickel versus pleiotrope pollen reaction.	2010 Jun	19758337
Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity.	2010 Jun 15	19844976
Involvement of prostaglandins and histamine in nickel wire-induced acute inflammation in mice.	2010 Jun 15	19839048
Genome-wide pathways analysis of nickel ion-induced differential genes expression in fibroblasts.	2010 Mar	20053437
IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes.	2010 May 1	20357258
Nickel induces oxidative burst, NF-κB activation and interleukin-8 production in human neutrophils.	2010 Nov	20632048
Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells.	2010 Sep 24	20682304
Gene expression changes in peripheral blood mononuclear cells in occupational exposure to nickel.	2011 Feb	21054559
Reactive oxygen species and oxidative DNA damage mediate the cytotoxicity of tungsten-nickel-cobalt alloys in vitro.	2011 Jan 1	20934443
In vitro evaluation of the toxicity induced by nickel soluble and particulate forms in human airway epithelial cells.	2011 Mar	21111804

Patents

Name

Type

Language

NICKEL

Systematic Name

English

RANEY NICKEL [MI]

Common Name

English

NICKEL [VANDF]

Common Name

English

NICCOLUM METALLICUM

Common Name

English

NICKEL [MI]

Common Name

English

Nickel [WHO-DD]

Common Name

English

NICCOLUM METALLICUM [HPUS]

Common Name

English

NICKEL [FCC]

Common Name

English

NI

Common Name

English

NICKEL [HSDB]

Common Name

English

METALLIC NICKEL

Common Name

English

CARBONYL-NICKEL

Systematic Name

English

NICKEL, METALLIC AND ALLOYS [IARC]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 184.1537