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Details

Stereochemistry ACHIRAL
Molecular Formula C13H16N4O3S
Molecular Weight 308.356
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of CYCOTIAMINE

SMILES

CC(N(CC1=C(N)N=C(C)N=C1)C=O)=C2CCOC(=O)S2

InChI

InChIKey=LLJDJQYGZBQFIF-DHZHZOJOSA-N
InChI=1S/C13H16N4O3S/c1-8(11-3-4-20-13(19)21-11)17(7-18)6-10-5-15-9(2)16-12(10)14/h5,7H,3-4,6H2,1-2H3,(H2,14,15,16)/b11-8+

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including, http://www.drugfuture.com/mt/thiamine-nitrate.pdf

Cycotiamine is a derivative of tiamine that was developed in Japan and used for the treatment of neurogenic bladder.

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8429
COMETAMIN

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[Clinical effects of cycothiamine (Cometamin) on neurogenic bladder: cystometric study].
1968 Oct
Patents

Patents

EP2702989 A1
2

Sample Use Guides

In Vivo Use Guide
900 to 3,700 mg given by intravenous administration.
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Name Type Language
CYCOTIAMINE
INN   MART.   WHO-DD  
INN  
Official Name English
N-((4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL)-N-(1-(2-OXO-1,3-OXATHIAN-4-YLIDENE)ETHYL)FORMAMIDE
Systematic Name English
CYCOTIAMINE [MART.]
Common Name English
cycotiamine [INN]
Common Name English
COMMETAMIN
Brand Name English
CYCLOCARBOTHIAMINE
Common Name English
Cycotiamine [WHO-DD]
Common Name English
CYCOTIAMINE [JAN]
Common Name English
CYCOTHIAMIN(E) [MI]
Common Name English
CARBOTHIAMINE
Common Name English
COMETAMINE
Brand Name English
N-(1-(2-OXO-1,3-OXATHIAN-4-YLIDENE)ETHYL)-N-((4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL)FORMAMIDE
Systematic Name English
CYCOTHIAMIN(E)
MI  
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C45812
Created by admin on Sat Dec 16 16:49:53 GMT 2023 , Edited by admin on Sat Dec 16 16:49:53 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C81629
Created by admin on Sat Dec 16 16:49:53 GMT 2023 , Edited by admin on Sat Dec 16 16:49:53 GMT 2023
PRIMARY
EPA CompTox
DTXSID2057784
Created by admin on Sat Dec 16 16:49:53 GMT 2023 , Edited by admin on Sat Dec 16 16:49:53 GMT 2023
PRIMARY
PUBCHEM
71666
Created by admin on Sat Dec 16 16:49:53 GMT 2023 , Edited by admin on Sat Dec 16 16:49:53 GMT 2023
PRIMARY
SMS_ID
100000083758
Created by admin on Sat Dec 16 16:49:53 GMT 2023 , Edited by admin on Sat Dec 16 16:49:53 GMT 2023
PRIMARY
INN
2245
Created by admin on Sat Dec 16 16:49:53 GMT 2023 , Edited by admin on Sat Dec 16 16:49:53 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106586
Created by admin on Sat Dec 16 16:49:53 GMT 2023 , Edited by admin on Sat Dec 16 16:49:53 GMT 2023
PRIMARY
FDA UNII
FT8753F8R9
Created by admin on Sat Dec 16 16:49:53 GMT 2023 , Edited by admin on Sat Dec 16 16:49:53 GMT 2023
PRIMARY
EVMPD
SUB06866MIG
Created by admin on Sat Dec 16 16:49:53 GMT 2023 , Edited by admin on Sat Dec 16 16:49:53 GMT 2023
PRIMARY
CAS
6092-18-8
Created by admin on Sat Dec 16 16:49:53 GMT 2023 , Edited by admin on Sat Dec 16 16:49:53 GMT 2023
PRIMARY
MERCK INDEX
m135
Created by admin on Sat Dec 16 16:49:53 GMT 2023 , Edited by admin on Sat Dec 16 16:49:53 GMT 2023
PRIMARY Merck Index
ACTIVE MOIETY
Structure of CYCOTIAMINE
NIH
NCATS
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