Acetiamine (syn. thianeurone or diacetamine) is a thiamine derivative which is rarely used in pharmaceuticals. It is lipid-soluble. It has been studied for the treatment of rheumatic diseases.

Teloxantrone (also known as DuP 937) was developed as an anthrapyrazole intercalator that inhibits DNA synthesis. Teloxantrone interacts with topoisomerase II, thereby inhibiting DNA replication and repair, as well as RNA and protein synthesis. The drug participated in phase II clinical trials in colorectal carcinoma, in non-small cell lung cancer, in metastatic malignant melanoma. However, these studied apparently were discontinued.

Pumafentrine is benzonaphthyridine derivative patented by BYk Gulden Lomberg Chemische Fabrik G.m.b.H. as phosphodiesterase (PDE) inhibitor useful for bronchial treatment. In preclinical trials, Pumafentrine acts as a mixed selective PDE-3/4 inhibitor. Treatment with pumafentrine from week 4 to 6 after a single injection of monocrotaline (partially reversed pulmonary hypertension and right heart hypertrophy in rats. In addition, small pulmonary arterial muscularization, medial hypertrophy and decrease in lumen area were largely reversed. Inhibition of smooth muscle proliferation under pumafentrine was demonstrated in vivo as was a pro-apoptotic effect of pumafentrine on vascular cells. Moreover, pumafentrine dose-dependently increased cyclic adenosine monophosphate levels and inhibited proliferation of cultured pulmonary arterial smooth muscle cells. Pumafentrine was used in phase 2 clinical trials for the treatment of asthma but was discontinued in 2002, reportedly due to a short duration of action. An active metabolite of pumafentrine, hydroxypumafentrine, has also been described, although there have been no published clinical data on this compound

Talosalate, a phthalidyl ester of acetylsalicylic acid, was used as an analgesic and anti-inflammatory agent. Talosalate was studied in preclinical experiments for the treatment of inflammation and rheumatic disorder in Argentina. However, the further development of the drug appears to have been discontinued.

Decloxizine (UCB-1402; NSC289116) is a histamine 1 receptor antagonist. Decloxizine is a broncholyticum.

Norgesterone (norvinodrel, vinylestrenolone) is a progestin medication which was formerly used in birth control pills for women. The compound shows no androgenic and very little estrogenic activity; its progestational effect, as well as other properties, suggests its use as claudogenic agent. Norgesterone is an agonist of the progesterone receptor. It was used in combination with ethinylestradiol in birth control pills to prevent pregnancy.

Metrenperone, a 5-hydroxytryptamine blocker, is used in veterinary as an antimyopathic agent. Experiments on rabbits have shown that the drug had positive effects on collagen turnover, remodeling, and organization during acute inflammation and fibroplasia.

Butikacin is deoxystreptamine aminoglycoside with bactericidal activity with good activity against Staphylococcus aureus and a range of gram-negative bacteria.

Cicrotoic acid is a biochemical drug that acts on bile flow and liquid composition of human bile.

Metamelfalan is an antineoplastic agent. Metamelfalan is the meta form of the levo isomer melphalan. Metamelfalan causes crosslinking of DNA, thereby preventing DNA replication and eventually cellular proliferation.