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Details

Stereochemistry ACHIRAL
Molecular Formula C24H26FN3O2
Molecular Weight 407.4805
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METRENPERONE

SMILES

CC1=CN2C(=O)C(CCN3CCC(CC3)C(=O)C4=CC=C(F)C=C4)=C(C)N=C2C=C1

InChI

InChIKey=AXQRPYKSPHUOGZ-UHFFFAOYSA-N
InChI=1S/C24H26FN3O2/c1-16-3-8-22-26-17(2)21(24(30)28(22)15-16)11-14-27-12-9-19(10-13-27)23(29)18-4-6-20(25)7-5-18/h3-8,15,19H,9-14H2,1-2H3

HIDE SMILES / InChI

Description

Metrenperone, a 5-hydroxytryptamine blocker, is used in veterinary as an antimyopathic agent. Experiments on rabbits have shown that the drug had positive effects on collagen turnover, remodeling, and organization during acute inflammation and fibroplasia.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
PubMed

PubMed

TitleDatePubMed
Economic, clinical and functional consequences of a treatment using metrenperone during an outbreak of shipping fever in cattle.
1993 Mar 6
Cardiovascular response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade, by metrenperone, in healthy calves.
1999 Jan
Effects of a serotonin S2-receptor blocker on healing of acute and chronic tendon injuries.
2009 Jul-Aug
Metrenperone enhances collagen turnover and remodeling in the early stages of healing of tendon injury in rabbit.
2010 Dec
Name Type Language
METRENPERONE
INN   USAN  
INN   USAN  
Official Name English
4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE, 3-(2-(4-(4-FLUOROBENZOYL)-1-PIPERIDINYL)ETHYL)-2,7-DIMETHYL-
Systematic Name English
metrenperone [INN]
Common Name English
3-(2-(4-(P-FLUOROBENZOYL)PIPERIDINO)ETHYL)-2,7-DIMETHYL-4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE
Common Name English
R 50 970
Code English
METRENPERONE [USAN]
Common Name English
R-50 970
Code English
R-50970
Code English
R 50970
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C66885
Created by admin on Fri Dec 15 16:30:45 GMT 2023 , Edited by admin on Fri Dec 15 16:30:45 GMT 2023
Code System Code Type Description
CAS
81043-56-3
Created by admin on Fri Dec 15 16:30:45 GMT 2023 , Edited by admin on Fri Dec 15 16:30:45 GMT 2023
PRIMARY
SMS_ID
100000080926
Created by admin on Fri Dec 15 16:30:45 GMT 2023 , Edited by admin on Fri Dec 15 16:30:45 GMT 2023
PRIMARY
PUBCHEM
72005
Created by admin on Fri Dec 15 16:30:45 GMT 2023 , Edited by admin on Fri Dec 15 16:30:45 GMT 2023
PRIMARY
USAN
BB-21
Created by admin on Fri Dec 15 16:30:45 GMT 2023 , Edited by admin on Fri Dec 15 16:30:45 GMT 2023
PRIMARY
FDA UNII
W1O4FV809G
Created by admin on Fri Dec 15 16:30:45 GMT 2023 , Edited by admin on Fri Dec 15 16:30:45 GMT 2023
PRIMARY
ECHA (EC/EINECS)
279-678-7
Created by admin on Fri Dec 15 16:30:45 GMT 2023 , Edited by admin on Fri Dec 15 16:30:45 GMT 2023
PRIMARY
EPA CompTox
DTXSID20230867
Created by admin on Fri Dec 15 16:30:45 GMT 2023 , Edited by admin on Fri Dec 15 16:30:45 GMT 2023
PRIMARY
EVMPD
SUB08917MIG
Created by admin on Fri Dec 15 16:30:45 GMT 2023 , Edited by admin on Fri Dec 15 16:30:45 GMT 2023
PRIMARY
NCI_THESAURUS
C80774
Created by admin on Fri Dec 15 16:30:45 GMT 2023 , Edited by admin on Fri Dec 15 16:30:45 GMT 2023
PRIMARY
ChEMBL
CHEMBL2104852
Created by admin on Fri Dec 15 16:30:45 GMT 2023 , Edited by admin on Fri Dec 15 16:30:45 GMT 2023
PRIMARY
INN
6033
Created by admin on Fri Dec 15 16:30:45 GMT 2023 , Edited by admin on Fri Dec 15 16:30:45 GMT 2023
PRIMARY
MESH
C046881
Created by admin on Fri Dec 15 16:30:45 GMT 2023 , Edited by admin on Fri Dec 15 16:30:45 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of METRENPERONE
NIH
NCATS
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