METRENPERONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H26FN3O2
Molecular Weight	407.4805
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CN2C(=O)C(CCN3CCC(CC3)C(=O)C4=CC=C(F)C=C4)=C(C)N=C2C=C1

InChI

InChIKey=AXQRPYKSPHUOGZ-UHFFFAOYSA-N

InChI=1S/C24H26FN3O2/c1-16-3-8-22-26-17(2)21(24(30)28(22)15-16)11-14-27-12-9-19(10-13-27)23(29)18-4-6-20(25)7-5-18/h3-8,15,19H,9-14H2,1-2H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20130893 | https://www.ncbi.nlm.nih.gov/pubmed/19842899

Metrenperone, a 5-hydroxytryptamine blocker, is used in veterinary as an antimyopathic agent. Experiments on rabbits have shown that the drug had positive effects on collagen turnover, remodeling, and organization during acute inflammation and fibroplasia.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 2 (5-HT2) receptor 90 Target ID: CHEMBL2095200 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8378609 \| https://www.ncbi.nlm.nih.gov/pubmed/8884022 \| https://www.ncbi.nlm.nih.gov/pubmed/8427462	Antagonist 2849

PubMed

Title	Date	PubMed
Metrenperone enhances collagen turnover and remodeling in the early stages of healing of tendon injury in rabbit.	2010-12	20130893
Effects of a serotonin S2-receptor blocker on healing of acute and chronic tendon injuries.	2009-10-22	19842899
Cardiovascular response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade, by metrenperone, in healthy calves.	1999-01	10030126
Economic, clinical and functional consequences of a treatment using metrenperone during an outbreak of shipping fever in cattle.	1993-03-06	8384736

Name

Type

Language

METRENPERONE

Official Name

English

R 50 970

Preferred Name

English

4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE, 3-(2-(4-(4-FLUOROBENZOYL)-1-PIPERIDINYL)ETHYL)-2,7-DIMETHYL-

Systematic Name

English

metrenperone [INN]

Common Name

English

3-(2-(4-(P-FLUOROBENZOYL)PIPERIDINO)ETHYL)-2,7-DIMETHYL-4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE

Common Name

English

METRENPERONE [USAN]

Common Name

English

R-50 970

Code

English

R-50970

Code

English

R 50970

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66885