U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C21H28N2O2
Molecular Weight 340.4592
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DECLOXIZINE

SMILES

OCCOCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=OXBBIHZWNDPBMQ-UHFFFAOYSA-N
InChI=1S/C21H28N2O2/c24-16-18-25-17-15-22-11-13-23(14-12-22)21(19-7-3-1-4-8-19)20-9-5-2-6-10-20/h1-10,21,24H,11-18H2

HIDE SMILES / InChI
Decloxizine (UCB-1402; NSC289116) is a histamine 1 receptor antagonist. Decloxizine is a broncholyticum.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

PubMed

PubMed

TitleDatePubMed
[Preliminary study of effects of decloxizine on air passage resistance in chronic bronchitis patients].
1968 Jul-Oct
[Protective effect of decloxizine in relation to bronchospasm due to histamine].
1968 Jul-Oct
Bronchodilator action of drug combinations in asthmatic patients: decloxizine, orciprenaline, and ephedrine.
1969 Jun
Effect of decloxizine on histamine aerosol induced bronchoconstriction in the conscious guinea-pig.
1969 Nov
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Intravenous route is possible https://www.ncbi.nlm.nih.gov/pubmed/4904306
Three daily 50 mg doses of decloxizine proved sufficient to prevent asthma attacks and shortness of breath in the patients examined
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
DECLOXIZINE
INN   WHO-DD  
INN  
Official Name English
UCB 1402
Code English
Decloxizine [WHO-DD]
Common Name English
decloxizine [INN]
Common Name English
NSC-289116
Code English
UCB-1402
Code English
DECLOXIZINE [USP IMPURITY]
Common Name English
HYDROXYZINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]
Common Name English
2-(2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)ETHOXY)ETHANOL
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29578
Created by admin on Fri Dec 15 16:33:18 GMT 2023 , Edited by admin on Fri Dec 15 16:33:18 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID40190777
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PRIMARY
ChEMBL
CHEMBL2106665
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PRIMARY
INN
2476
Created by admin on Fri Dec 15 16:33:18 GMT 2023 , Edited by admin on Fri Dec 15 16:33:18 GMT 2023
PRIMARY
EVMPD
SUB06936MIG
Created by admin on Fri Dec 15 16:33:18 GMT 2023 , Edited by admin on Fri Dec 15 16:33:18 GMT 2023
PRIMARY
SMS_ID
100000083493
Created by admin on Fri Dec 15 16:33:18 GMT 2023 , Edited by admin on Fri Dec 15 16:33:18 GMT 2023
PRIMARY
NCI_THESAURUS
C76673
Created by admin on Fri Dec 15 16:33:18 GMT 2023 , Edited by admin on Fri Dec 15 16:33:18 GMT 2023
PRIMARY
CAS
3733-63-9
Created by admin on Fri Dec 15 16:33:18 GMT 2023 , Edited by admin on Fri Dec 15 16:33:18 GMT 2023
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FDA UNII
919C49XAYD
Created by admin on Fri Dec 15 16:33:18 GMT 2023 , Edited by admin on Fri Dec 15 16:33:18 GMT 2023
PRIMARY
NSC
289116
Created by admin on Fri Dec 15 16:33:18 GMT 2023 , Edited by admin on Fri Dec 15 16:33:18 GMT 2023
PRIMARY
PUBCHEM
71135
Created by admin on Fri Dec 15 16:33:18 GMT 2023 , Edited by admin on Fri Dec 15 16:33:18 GMT 2023
PRIMARY