DECLOXIZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H28N2O2
Molecular Weight	340.4592
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCOCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=OXBBIHZWNDPBMQ-UHFFFAOYSA-N

InChI=1S/C21H28N2O2/c24-16-18-25-17-15-22-11-13-23(14-12-22)21(19-7-3-1-4-8-19)20-9-5-2-6-10-20/h1-10,21,24H,11-18H2

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4395228 | https://www.medchemexpress.com/decloxizine.html

Decloxizine (UCB-1402; NSC289116) is a histamine 1 receptor antagonist. Decloxizine is a broncholyticum.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 315 Target ID: CHEMBL231 Sources: https://www.medchemexpress.com/decloxizine.html	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bronchitis 51 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5739759 https://www.ncbi.nlm.nih.gov/pubmed/4904306	Primary		Preclinical	Unknown Approved Use Unknown
Asthma 241 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5739759 https://www.ncbi.nlm.nih.gov/pubmed/4904306	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Preliminary study of effects of decloxizine on air passage resistance in chronic bronchitis patients].	1968 Jul-Oct	5739763
[Protective effect of decloxizine in relation to bronchospasm due to histamine].	1968 Jul-Oct	5739761
Bronchodilator action of drug combinations in asthmatic patients: decloxizine, orciprenaline, and ephedrine.	1969 Jun	4891707
Effect of decloxizine on histamine aerosol induced bronchoconstriction in the conscious guinea-pig.	1969 Nov	4391496

Patents

Sample Use Guides

In Vivo Use Guide

Three daily 50 mg doses of decloxizine proved sufficient to prevent asthma attacks and shortness of breath in the patients examined

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

DECLOXIZINE

Official Name

English

UCB 1402

Code

English

Decloxizine [WHO-DD]

Common Name

English

decloxizine [INN]

Common Name

English

NSC-289116

Code

English

UCB-1402

Code

English

DECLOXIZINE [USP IMPURITY]

Common Name

English

HYDROXYZINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Common Name

English

2-(2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)ETHOXY)ETHANOL

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578