DECLOXIZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H28N2O2
Molecular Weight	340.4592
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCOCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=OXBBIHZWNDPBMQ-UHFFFAOYSA-N

InChI=1S/C21H28N2O2/c24-16-18-25-17-15-22-11-13-23(14-12-22)21(19-7-3-1-4-8-19)20-9-5-2-6-10-20/h1-10,21,24H,11-18H2

HIDE SMILES / InChI

Molecular Formula	C21H28N2O2
Molecular Weight	340.4592
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4395228 | https://www.medchemexpress.com/decloxizine.html

Decloxizine (UCB-1402; NSC289116) is a histamine 1 receptor antagonist. Decloxizine is a broncholyticum.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 316 Target ID: CHEMBL231 Sources: https://www.medchemexpress.com/decloxizine.html	Antagonist 2849

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bronchitis 51 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5739759 https://www.ncbi.nlm.nih.gov/pubmed/4904306	Primary		Preclinical	Unknown Approved Use Unknown
Asthma 244 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5739759 https://www.ncbi.nlm.nih.gov/pubmed/4904306	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Effect of decloxizine on histamine aerosol induced bronchoconstriction in the conscious guinea-pig.	1969-11	4391496
Bronchodilator action of drug combinations in asthmatic patients: decloxizine, orciprenaline, and ephedrine.	1969-06	4891707
[Preliminary study of effects of decloxizine on air passage resistance in chronic bronchitis patients].	1968-07-01	5739763
[Protective effect of decloxizine in relation to bronchospasm due to histamine].	1968-07-01	5739761

Patents

Sample Use Guides

In Vivo Use Guide

Three daily 50 mg doses of decloxizine proved sufficient to prevent asthma attacks and shortness of breath in the patients examined

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:31:15 GMT 2025` Edited by `admin` on `Mon Mar 31 18:31:15 GMT 2025`
Record UNII	919C49XAYD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DECLOXIZINE

Official Name

English

NSC-289116

Preferred Name

English

UCB 1402

Code

English

Decloxizine [WHO-DD]

Common Name

English

decloxizine [INN]

Common Name

English

UCB-1402

Code

English

DECLOXIZINE [USP IMPURITY]

Common Name

English

HYDROXYZINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Common Name

English

2-(2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)ETHOXY)ETHANOL

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578