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Restrict the search for
histamine
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Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ACHIRAL)
Talastine (trade name Ahanon), an alkylamine H1-antihistamine, was studied as a reason for an allergic drug exanthema.
Status:
Possibly Marketed Outside US
Source:
Tolpropamine by Hoechst (Aventis)
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
TOLPROPAMINE is an alkylamine H1-antihistamine used as an antipruritic and topical antihistaminic.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (MIXED)
Conditions:
Antihistamine agent
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Moperone is a first-generation (typical) antipsychotic drug that belongs to the butyrophenone type approved in Japan for the treatment of schizophrenia. It has higher antagonist affinity for D2- than 5-HT2A-receptors. It also has high binding affinity for sigma receptors. It was indicated for schizophrenia, paranoid state, psychoses, epilepsy,alcohol withdrawal syndrome. It can induce extrapyramidal motor side effects, insomnia, and thirst, but it displays generally low toxicity.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (RACEMIC)
Quifenadine is an antihistaminic agent.
Quifenadine both blocks histamine H1-receptors in the peripheral tissues, and activates enzyme diaminoxidase (histaminase), due to this decreasing the histamine concentration in tissues.
It is indicated in cases of pollinosis, acute and chronic urticaria, seasonal rhinitis (hay fever), allergic rhinitis, allergic conjunctivitis, angioneurotic Quinqe’s edema, dermatosis (eczema, neurodermatitis, pruritus etc.), allergic reactions caused by food or medicines. Quifanidine exhibits antiarrhythmic activity in children with frequent premature beats, without significant QT prolongation, or sinus node depression.
Status:
Possibly Marketed Outside US
Source:
NCT04702971: Phase 4 Interventional Recruiting Migraine
(2021)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 / dopamine D2 blocking activity. It is not available in the US but marketed in other countries for prophylaxis of a migraine, occlusive peripheral vascular disease, the vertigo of central and peripheral origin, motion sickness and as an adjuvant in the therapy of epilepsy. The drug is also investigated for the treatment of schizophrenia.
Status:
Possibly Marketed Outside US
Source:
Alinastine by Fabrica Espanola de
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Alinastine, a histamine H1 receptor antagonist, that was studied for allergic conjunctivitis, for asthma and for skin disorders, but these experiments were discontinued.
Status:
Possibly Marketed Outside US
Source:
Vialibran by Servier
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Medibazine (Vialibran) is a piperazine derivative. Medibazine is a coronary vasodilating agent. Although several non-controlled trials report favorable results with angina patients this medication certainly does not provide any outstanding results.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ACHIRAL)
Niperotidine is an H2 antagonist structurally related to ranitidine. H2 antagonists inhibit gastric acid secretion by selectively blocking histamine receptor type 2. Niperotidine was proposed for the treatment of peptic ulcer. Bedtime dose of niperotidine inhibits nocturnal gastric acid secretion in healthy subjects. The duration of niperotidine action was 5 to 7 hours. Twenty-five cases of acute hepatitis (including one death from fulminant hepatitis) associated with niperotidine use were reported in Italy between March and August 1995 and drug was withdrawn from the market. The methylenedioxy group of niperotidine is known to undergo metabolism to catechol and quinone metabolites.
Status:
Possibly Marketed Outside US
Source:
TERCIAN by Rhône-Poulenc
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class used primarily in the treatment of schizophrenia and psychosis-associated anxiety. Cyamemazine actually behaves like an atypical antipsychotic, due to its potent anxiolytic effects and lack of extrapyramidal side effects. Cyamemazine is used for the treatment of chronic psychotic states, anxiety, major depression.
