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Details

Stereochemistry ACHIRAL
Molecular Formula C22H26FNO2
Molecular Weight 355.4457
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MOPERONE

SMILES

CC1=CC=C(C=C1)C2(O)CCN(CCCC(=O)C3=CC=C(F)C=C3)CC2

InChI

InChIKey=AGAHNABIDCTLHW-UHFFFAOYSA-N
InChI=1S/C22H26FNO2/c1-17-4-8-19(9-5-17)22(26)12-15-24(16-13-22)14-2-3-21(25)18-6-10-20(23)11-7-18/h4-11,26H,2-3,12-16H2,1H3

HIDE SMILES / InChI

Molecular Formula C22H26FNO2
Molecular Weight 355.4457
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Moperone is a first-generation (typical) antipsychotic drug that belongs to the butyrophenone type approved in Japan for the treatment of schizophrenia. It has higher antagonist affinity for D2- than 5-HT2A-receptors. It also has high binding affinity for sigma receptors. It was indicated for schizophrenia, paranoid state, psychoses, epilepsy,alcohol withdrawal syndrome. It can induce extrapyramidal motor side effects, insomnia, and thirst, but it displays generally low toxicity.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
87.0 nM [EC50]
1.5 nM [Ki]
6.1 null [pIC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Luvatrene
Primary
Luvatrene

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Starting dose is 0.2-0.3 mg/kg/day; then slowly increase to 0.04-0.06 mg/kg/day
Route of Administration: Unknown
In Vitro Use Guide
Moperone was tested at a 3 uM concentration
Substance Class Chemical
Record UNII
OU730881W5
Record Status Validated (UNII)
Record Version