QUIFENADINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H23NO
Molecular Weight	293.4027
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(C1CN2CCC1CC2)(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=PZMAHNDJABQWGS-UHFFFAOYSA-N

InChI=1S/C20H23NO/c22-20(17-7-3-1-4-8-17,18-9-5-2-6-10-18)19-15-21-13-11-16(19)12-14-21/h1-10,16,19,22H,11-15H2

HIDE SMILES / InChI

Description
Sources: https://olainfarm.al/wp-content/uploads/2013/02/Fenkarol_Summary-of-Product-Characteristics.pdf | https://www.ncbi.nlm.nih.gov/pubmed/19487925

Quifenadine is an antihistaminic agent. Quifenadine both blocks histamine H1-receptors in the peripheral tissues, and activates enzyme diaminoxidase (histaminase), due to this decreasing the histamine concentration in tissues. It is indicated in cases of pollinosis, acute and chronic urticaria, seasonal rhinitis (hay fever), allergic rhinitis, allergic conjunctivitis, angioneurotic Quinqe’s edema, dermatosis (eczema, neurodermatitis, pruritus etc.), allergic reactions caused by food or medicines. Quifanidine exhibits antiarrhythmic activity in children with frequent premature beats, without significant QT prolongation, or sinus node depression.

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

For adults: single dose is 25-50 mg 2-4 times a day. Maximum daily dose is 200 mg. For children older than 12 years - 25 mg 2-3 times a day. The duration of the course of treatment is 10-20 days. If it is necessary, the course of treatment may be repeated.

Route of Administration: Oral

Name

Type

Language

Quifenadine [WHO-DD]

Preferred Name

English

QUIFENADINE

Official Name

English

quifenadine [INN]

Common Name

English

.ALPHA.,.ALPHA.-DIPHENYL-3-QUINUCLIDINEMETHANOL

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578