U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 331 - 340 of 574 results

Permethrin is a synthetic pyrethrin derivative acts as a neurotoxin by depolarizing the nerve cell membrane. Permethrin disrupts the sodium channel current by which membrane repolarization is regulated resulting in fatal paralysis of the nerves in the exoskeletal respiratory muscles of susceptible arthropods, including lice and mite. Permethrin is sold under brand names NIx and Elimite to treat pediculosis, scabies and demodicidosis.
mixture
Status:
US Approved OTC
Source:
21 CFR 349.12(e) ophthalmic:demulcents polyvinyl alcohol
Source URL:
First approved in 1984
Source:
Hemocyte F by US Pharmaceutical Corporation
Source URL:

Class:
MIXTURE

mixture
Status:
Other

Class:
MIXTURE

mixture
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(22)(ii) antifungal:diaper rash basic fuchsin
Source URL:

Class:
MIXTURE


Fuchsine (rosaniline hydrochloride) is a magenta dye. Basic fuchsine is a mixture of rosaniline, pararosaniline, new fuchsine and Magenta II. Carbol fuchsin is a mixture of phenol and basic fuchsin, used in bacterial staining procedures. It is commonly used in the staining of mycobacteria as it has an affinity for the mycolic acids found in their cell membranes. The World Health Organization recommendation of 0.3% carbol fuchsin in the ZN method for staining acid-fast bacilli (AFB).
mixture
Status:
US Previously Marketed
Source:
Spontin by Abbott
(1957)
Source URL:
First approved in 1957
Source:
Spontin by Abbott
Source URL:

Class:
MIXTURE

mixture
Status:
US Previously Marketed
First approved in 1944

Class:
MIXTURE

mixture
Status:
US Previously Marketed
Source:
21 CFR 310.527(a) hair loss prevention polysorbate 60
Source URL:
First approved in 1938
Source:
Belladonna and Opium by Bryant Ranch Prepack
Source URL:

Class:
MIXTURE

Acriflavine (ACF) is a topical antiseptic. The hydrochloride form is more irritating than the neutral form. It is derived from acridine. Commercial preparations are often mixtures with proflavine. Acriflavine was developed in 1912 by Paul Ehrlich, a German medical researcher, and was used during the First World War against sleeping sickness. ACF has known trypanocidal, antibacterial, and antiviral activities. Effects of ACF on cancer cells were first reported 50 years ago. By present time was demonstrated that ACF a drug, that binds directly to HIF-1 alpha and HIF-2 alpha and inhibits HIF-1 dimerization and transcriptional activity and thus has potent inhibitory effects on tumor growth and vascularization. Also Acriflavine in combination with 3,6-diaminoacridine (proflavine) could prove to be a potential antimalarial drug and its pharmacological action can be due to inhibition of gyrase activity. This is achieved through interaction of the ACF with the DNA substrate. This interaction may lead to conformation change in DNA unsuitable for binding of gyrase with DNA.

Showing 331 - 340 of 574 results