U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

PubMed

PubMed

TitleDatePubMed
Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently.
2015-04-01
Correlation of gene expression and contaminant concentrations in wild largescale suckers: a field-based study.
2014-06-15
Regulation of hepatic drug transporter activity and expression by organochlorine pesticides.
2014-03
Hypothyroidism and pesticide use among male private pesticide applicators in the agricultural health study.
2013-10
Characteristic molecular signature for early detection and prediction of persistent organic pollutants in rat liver.
2012-12-04
Differential effects of a complex organochlorine mixture on the proliferation of breast cancer cell lines.
2011-04
Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays.
2011-02-27
Fetal exposure to chlordane and permethrin mixtures in relation to inflammatory cytokines and birth outcomes.
2011-02-15
Regulation and dysregulation of vitellogenin mRNA accumulation in daphnids (Daphnia magna).
2011-01-25
Inhibition of connexin 43 gap junction channels by the endocrine disruptor ioxynil.
2010-08-15
Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.
2010-08
Pesticide use and thyroid disease among women in the Agricultural Health Study.
2010-02-15
The B[a]P-increased intercellular communication via translocation of connexin-43 into gap junctions reduces apoptosis.
2010-01-15
Pesticide use and adult-onset asthma among male farmers in the Agricultural Health Study.
2009-12
Incident diabetes and pesticide exposure among licensed pesticide applicators: Agricultural Health Study, 1993-2003.
2008-05-15
Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study.
2007-02-01
Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells.
2007-01
Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line.
2006-11-10
Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines.
2006-08-15
Estrogen-related receptors as emerging targets in cancer and metabolic disorders.
2006
CAR and PXR: xenosensors of endocrine disrupters?
2005-08-15
Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue.
2005-05
Activation of retinoic acid receptor-dependent transcription by organochlorine pesticides.
2005-01-01
A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides.
2004-12-15
Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells.
2004-04
Carcinogen-metabolizing enzymes and insecticides.
2004
PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides.
2002-11-15
Modulation of prolactin expression by xenoestrogens.
2002-04
Modulation of aromatase expression in human breast tissue.
2001-12
Role of PKC and MAP kinase in EGF- and TPA-induced connexin43 phosphorylation and inhibition of gap junction intercellular communication in rat liver epithelial cells.
2001-09
Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor alpha-1 orphan receptor.
1999-09-15
Effect of the chlorinated hydrocarbons heptachlor, chlordane, and toxaphene on retinoblastoma tumor suppressor in human lymphocytes.
1999-01-11
The human acrosome reaction is highly sensitive to inhibition by cyclodiene insecticides.
1998-02-12
Quantitative relationship between transforming growth factor-alpha and hepatic focal phenotype and progression in female mouse liver.
1997-05-01
In vitro synergistic interaction of alligator and human estrogen receptors with combinations of environmental chemicals.
1997-04
In vitro and in vivo induction of heat shock (stress) protein (Hsp) gene expression by selected pesticides.
1996-08-01
Comparison of the activity of topically applied pesticides and the herbicide 2,4-D in two short-term in vivo assays of genotoxicity in the mouse.
1990-11
Morphologic and cytochemical properties of mouse liver neoplasms induced by diethylnitrosamine and promoted by 4,4'-dichlorodiphenyltrichloroethane, chlordane, or heptachlor.
1985
Effect of parathion, malathion, endosulfan and chlordane on porphyrin accumulation and ALA-synthetase in chick embryo liver.
1982
Patents

Patents

Substance Class Mixture
Created
by admin
on Mon Mar 31 18:35:46 GMT 2025
Edited
by admin
on Mon Mar 31 18:35:46 GMT 2025
Record UNII
A9RLM212CY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHLORDANE
HSDB   MART.   MI  
Common Name English
CORODANE
Preferred Name English
INTOX
Brand Name English
SYNKLOR
Brand Name English
CHLORDAN
Common Name English
CHLORDANE [HSDB]
Common Name English
CHLORDANE [MI]
Common Name English
TOXICHLOR
Brand Name English
1,2,4,5,6,7,8,8-OCTACHLORO-2,3,3A,4,7,7A-HEXAHYDRO-4,7-METHANO-1H-INDENE
Common Name English
DOWCHLOR
Brand Name English
M-140
Code English
CHLORDANE [IARC]
Common Name English
NSC-8931
Code English
CHLORDANE [MART.]
Common Name English
ORTHO-KLOR
Brand Name English
OCTACHLOR
Brand Name English
NIRAN
Brand Name English
COMPOUND K
Common Name English
TAT CHLOR 4
Brand Name English
ENT-9932
Code English
CHLORINDAN
Common Name English
HCS-3260
Code English
OKTATERR
Brand Name English
CD-68
Code English
VELSICOL 1068
Brand Name English
1,2,4,5,6,7,8,8-OCTACHLORO-2,3,3A,4,7,7A-HEXAHYDRO-4,7-METHANOINDENE
Common Name English
TECHNICAL CHLORDANE
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 58201
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
IARC Chlordane
NCI_THESAURUS C737
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
Code System Code Type Description
FDA UNII
A9RLM212CY
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
PRIMARY
EVMPD
SUB33050
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
PRIMARY
ECHA (EC/EINECS)
200-349-0
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
PRIMARY
MERCK INDEX
m3353
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
PRIMARY Merck Index
CHEBI
34623
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
PRIMARY
NSC
8931
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
PRIMARY
WIKIPEDIA
CHLORDANE
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
PRIMARY
ALANWOOD
chlordane
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
PRIMARY
CAS
12789-03-6
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
NO STRUCTURE GIVEN
SMS_ID
100000125925
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
PRIMARY
HSDB
802
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
PRIMARY
CAS
57-74-9
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
PRIMARY
EPA CompTox
DTXSID7020267
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
PRIMARY
NCI_THESAURUS
C29814
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
PRIMARY
MESH
D002706
Created by admin on Mon Mar 31 18:35:46 GMT 2025 , Edited by admin on Mon Mar 31 18:35:46 GMT 2025
PRIMARY
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Related Record Type Details
METABOLITE -> PARENT
METABOLITE -> PARENT
Related Record Type Details
ACTIVE MOIETY
Definition References