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Restrict the search for
m sacubitril
to a specific field?
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2013)
Source URL:
First approved in 2011
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Ursolic acid is a natural terpene compond found in a wide variety of plants but most well known for being in apple peels. Ursolic acid has a series of biological effects such as sedative, anti-inflammatory, anti-bacterial, anti-diabetic, antiulcer, antitumor etc. Ursolic acid has been shown to target multiple proinflammatory transcription factors, cell cycle proteins, growth factors, kinases, cytokines, chemokines, adhesion molecules, and inflammatory enzymes.
Evidences suggest that ursolic acid could be used as a potential candidate to develop a comprehensive competent strategy towards the treatment and prevention of health disorders.
Although the science is preliminary, it seems to be able to reduce fat accumulation and increase muscle mass gain when in a fed state, and to induce fat burning and preserve muscle mass when in a fasted state.
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2021)
Source URL:
First approved in 2010
Source:
Aquax Repellent by Pella Pharmaceuticals Co. Ltd
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
NCT02140073: Phase 4 Interventional Unknown status GERD
(2013)
Source URL:
First approved in 2009
Source:
MIF900001
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Domperidone is a peripherally selective D2 receptor antagonist. It acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine. Domperidone was not approved in USA due to risks of cardiac arrhythmias, cardiac arrest, and sudden death, but is available in other countries. However, FDA allows access to Domperidone through an expanded access investigational new drug application (IND) to patients with gastroesophageal reflux disease with upper GI symptoms, gastroparesis, and chronic constipation. As an “off-label” use, domperidone is prescribed to breastfeeding women to enhance their milk production.
Status:
Possibly Marketed Outside US
Source:
M020
(2023)
Source URL:
First approved in 2009
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2009)
Source URL:
First approved in 2009
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
O-Cymen-5-OL is an antifungal preservative used in cosmetics and beauty products to prevent harmful bacteria from developing and to prolong the shelf-life of formulas. It is part of the Isopropyl Cresols family and is originally developed synthetically in the form of a crystal. O-Cymen-5-OL is also used as a cosmetic biocide, or ingredient that helps to cleanse the skin or to prevent odor by destroying or inhibiting the growth of microorganisms, according to research. O-Cymen-5-OL is approved by the FDA for use as a direct and indirect food additive and has been approved by the CIR for use in cosmetics up to .5% concentration. However, in the European Union, it is only approved for use up to .1%. Studies in Japan, some dating back to 1956, found O-Cymen-5-OL to be neurotoxic in animals and have led to heavier restrictions on its use in cosmetics there. O-Cymen-5-OL (Dekasol BL) is used in oral care, to fight periodontal disease.
Status:
Possibly Marketed Outside US
First approved in 2009
Source:
NADA141060
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Decoquinate is a quinolone derivative that is used in the control of coccidiosis in domestic animals. Decoquinate treats and prevents coccidiosis in chickens, cattle, goats, sheep, etc. Decoquinate acts on sporozoites development and prevents their penetration of the gut epithelium. Decoquinate inhibits mitochondrial respiration and electron transport in Eimeria.
Status:
Possibly Marketed Outside US
Source:
21 CFR 347
(2017)
Source URL:
First approved in 2008
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
NCT03915535: Phase 4 Interventional Terminated Healthy Athletes
(2019)
Source URL:
First approved in 2007
Source:
DHA by Exeltis USA, Inc
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Doconexent (Docosahexaenoic acid, DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. DHA is widely used as a food supplement, and is beleived to support healthy brain development in young childred, prevent cardiovascular disease and cognitive decline during Alzheimer's disease. Most of these claims, however, were not supported by clinical trials. DHA spray is used as a tanner.
Status:
Possibly Marketed Outside US
Source:
M016
(2012)
Source URL:
First approved in 2007
Source:
M005
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Hydroxytyrosol is an important phenolic compound obtained from olive oil. Hydroxytyrosol possesses anti-inflammatory properties and has the capacity to inhibit cyclooxygenase and lipoxygenase enzymes. Hydroxytyrosol is a powerful antioxidant due to its protective function in cells. Hydroxytyrosol protects the cardiovascular system, avoiding oxidation of LDL cholesterol, maintaining normal blood HDL cholesterol concentrations and thus preventing atherosclerosis. Hydroxytyrosol protects brain cells from lipid peroxidation because it easy penetrates through the blood-brain barrier. Thus, the compound can be used in the disease treatment of Alzheimer or Parkinson. In addition, the compound also helps to prevent osteoporosis because its consumption has positive effects on the formation and growth of bones. Hydroxytyrosol is under investigation phase II clinical trials for breast cancer women to evaluate its effect on mammographic density. The recently published article has shown hydroxytyrosol could prevent obesity and insulin resistance by altering the composition of the intestinal microbiota and improving the integrity of the intestinal wall.
Status:
Possibly Marketed Outside US
First approved in 2006
Source:
Embutramide by PROCOS S.p.A.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Embutramide is a veterinary, CNS active medicine used for euthanasia in dogs. The drug is marketed under the name Tributame in the USA and under the name Tanax in Europe. Human consumption of the drug is usually associated with suicide attempts.
