URSOLIC ACID

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C30H48O3
Molecular Weight	456.7003
Optical Activity	UNSPECIFIED
Defined Stereocenters	10 / 10
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O

InChI

InChIKey=WCGUUGGRBIKTOS-GPOJBZKASA-N

InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C30H48O3
Molecular Weight	456.7003
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	10 / 10
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://korea.in-cosmetics.com/en/Exhibitors/2695677/GfN-GmbH-Selco-GmbH/Products/1138708/Ursolic-acid-Na-salt-natural | https://www.ulprospector.com/en/na/PersonalCare/Detail/6837/373852/Ursolic-Acid-Sodium-Salt-Salvia-Officinalis-Extracthttps://examine.com/supplements/ursolic-acid/
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/24374755 | https://www.ncbi.nlm.nih.gov/pubmed/23499879 | https://www.ncbi.nlm.nih.gov/pubmed/26610440 | https://www.ncbi.nlm.nih.gov/pubmed/26775565

Ursolic acid is a natural terpene compond found in a wide variety of plants but most well known for being in apple peels. Ursolic acid has a series of biological effects such as sedative, anti-inflammatory, anti-bacterial, anti-diabetic, antiulcer, antitumor etc. Ursolic acid has been shown to target multiple proinflammatory transcription factors, cell cycle proteins, growth factors, kinases, cytokines, chemokines, adhesion molecules, and inflammatory enzymes. Evidences suggest that ursolic acid could be used as a potential candidate to develop a comprehensive competent strategy towards the treatment and prevention of health disorders. Although the science is preliminary, it seems to be able to reduce fat accumulation and increase muscle mass gain when in a fed state, and to induce fat burning and preserve muscle mass when in a fasted state.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
protein folding 2 Target ID: GO:0006457 Sources: https://www.ulprospector.com/en/na/PersonalCare/Detail/6837/373852/Ursolic-Acid-Sodium-Salt-Salvia-Officinalis-Extract	Modulator 846
collagen biosynthetic process 3 Target ID: GO:0032964 Sources: https://www.ulprospector.com/en/na/PersonalCare/Detail/6837/373852/Ursolic-Acid-Sodium-Salt-Salvia-Officinalis-Extract	Activator 1447
Elastase 4 Target ID: Elastase Sources: http://korea.in-cosmetics.com/en/Exhibitors/2695677/GfN-GmbH-Selco-GmbH/Products/1138708/Ursolic-acid-Na-salt-natural	Inhibitor 8504
response to oxidative stress 20 Target ID: GO:0006979 Sources: https://www.ulprospector.com/en/na/PersonalCare/Detail/604/640714/Sodium-Ursolate	Modulator 846
Platelet glycoprotein 4 3 Target ID: CHEMBL1744526 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17404266/	Interacts 323
Cytochrome P450 19A1 39 Target ID: CHEMBL1978 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18192087	Inhibitor 8504	32.0 µM [IC50]
Aldose reductase 45 Target ID: CHEMBL1900 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22332359	Inhibitor 8504
Protein-tyrosine phosphatase 1B 34 Target ID: CHEMBL335 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16534732	Inhibitor 8504	3.8 µM [IC50]
11-beta-hydroxysteroid dehydrogenase 1 6 Target ID: CHEMBL4235 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20100662	Inhibitor 8504

Conditions

Condition	Modality	Highest Phase	Product
Photoaging of skin 4 Sources: https://www.ulprospector.com/en/eu/PersonalCare/Detail/3345/93891/Ursolic-Acid-Sodium-Salt https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=27ced99b-59a5-473f-90c5-f72b7e48ebdc&type=pdf&name=27ced99b-59a5-473f-90c5-f72b7e48ebdc	Inactive ingredient	Not Provided 511	PREVENTAGE FIRMING DEFENSE NORMAL/OILY BROAD SPECTRUM SPF 15 MERLE NORMAN Approved Use Unknown
Sarcopenia 3 Sources: https://examine.com/supplements/ursolic-acid	Primary	Phase III 665	Unknown Approved Use Unknown
Metabolic syndrome 34 Sources: https://examine.com/supplements/ursolic-acid	Primary	Phase II 1147	Unknown Approved Use Unknown
Male fertility 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15854639 DOI: 10.1002/(SICI)1099-1573(19980201)12:1<32::AID-PTR185>3.0.CO;2-4 https://examine.com/supplements/ursolic-acid/#ref63	Preventing	Preclinical	Unknown Approved Use Unknown
Cancer 609 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24374755 https://www.ncbi.nlm.nih.gov/pubmed/23499879	Primary	Preclinical	Unknown Approved Use Unknown
Inflammation 105 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18812028/	Primary	Preclinical	Unknown Approved Use Unknown

C_max

Value	Dose	Analyte	Population
1211 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	74 mg/m² 1 times / day multiple, intravenous dose: 74 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3457 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	98 mg/m² single, intravenous dose: 98 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2865 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	74 mg/m² single, intravenous dose: 74 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1835 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	37 mg/m² single, intravenous dose: 37 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
4834 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	74 mg/m² 1 times / day multiple, intravenous dose: 74 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
9696 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	98 mg/m² single, intravenous dose: 98 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
7175 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	74 mg/m² single, intravenous dose: 74 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4203 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	37 mg/m² single, intravenous dose: 37 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	74 mg/m² 1 times / day multiple, intravenous dose: 74 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3.9 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	98 mg/m² single, intravenous dose: 98 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4.46 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	74 mg/m² single, intravenous dose: 74 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4.59 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	37 mg/m² single, intravenous dose: 37 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
130 mg/m2 single, intravenous Highest studied dose Dose: 130 mg/m2 Route: intravenous Route: single Dose: 130 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy Health Status: unhealthy Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	DLT: ALT increased, AST increased... Other AEs: GGT increased... Dose limiting toxicities: ALT increased (grade 3, 2 patients) AST increased (grade 3, 2 patients) Direct bilirubin increased (grade 3, 2 patients) Other AEs: GGT increased (grade 2, 2 patients) Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
94 mg/m2 single, intravenous MTD Dose: 94 mg/m2 Route: intravenous Route: single Dose: 94 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy Health Status: unhealthy Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	DLT: ALT increased, GGT increased... Other AEs: AST increased... Dose limiting toxicities: ALT increased (grade 3, 1 pt) GGT increased (grade 3, 1 pt) Other AEs: AST increased (grade 2, 2 patients) Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
74 mg/m2 single, intravenous Studied dose Dose: 74 mg/m2 Route: intravenous Route: single Dose: 74 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy Health Status: unhealthy Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	DLT: AST increased, ALT increased... Dose limiting toxicities: AST increased (grade 3, 1 pt) ALT increased (grade 3, 1 pt) diarrhea (grade 3, 1 pt) Sources: https://pubmed.ncbi.nlm.nih.gov/23134084

AEs

AE	Significance	Dose	Population
GGT increased	grade 2, 2 patients	130 mg/m2 single, intravenous Highest studied dose Dose: 130 mg/m2 Route: intravenous Route: single Dose: 130 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy Health Status: unhealthy Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
ALT increased	grade 3, 2 patients DLT	130 mg/m2 single, intravenous Highest studied dose Dose: 130 mg/m2 Route: intravenous Route: single Dose: 130 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy Health Status: unhealthy Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
AST increased	grade 3, 2 patients DLT	130 mg/m2 single, intravenous Highest studied dose Dose: 130 mg/m2 Route: intravenous Route: single Dose: 130 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy Health Status: unhealthy Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
Direct bilirubin increased	grade 3, 2 patients DLT	130 mg/m2 single, intravenous Highest studied dose Dose: 130 mg/m2 Route: intravenous Route: single Dose: 130 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy Health Status: unhealthy Sex: M Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
AST increased	grade 2, 2 patients	94 mg/m2 single, intravenous MTD Dose: 94 mg/m2 Route: intravenous Route: single Dose: 94 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy Health Status: unhealthy Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
ALT increased	grade 3, 1 pt DLT	94 mg/m2 single, intravenous MTD Dose: 94 mg/m2 Route: intravenous Route: single Dose: 94 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy Health Status: unhealthy Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
GGT increased	grade 3, 1 pt DLT	94 mg/m2 single, intravenous MTD Dose: 94 mg/m2 Route: intravenous Route: single Dose: 94 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy Health Status: unhealthy Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
ALT increased	grade 3, 1 pt DLT	74 mg/m2 single, intravenous Studied dose Dose: 74 mg/m2 Route: intravenous Route: single Dose: 74 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy Health Status: unhealthy Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
AST increased	grade 3, 1 pt DLT	74 mg/m2 single, intravenous Studied dose Dose: 74 mg/m2 Route: intravenous Route: single Dose: 74 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy Health Status: unhealthy Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
diarrhea	grade 3, 1 pt DLT	74 mg/m2 single, intravenous Studied dose Dose: 74 mg/m2 Route: intravenous Route: single Dose: 74 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy Health Status: unhealthy Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/23134084

Sourcing

Vendor/Aggregator	ID	URL
1PlusChem LLC	1P003694	https://www.1pchem.com/search?query=1P003694
A2B Chem	AB47272	http://a2bchem.com/prod/AB47272
Accela ChemBio Inc	SY036316	http://accelachem.com/cn/search.html?keyword=SY036316&attname=0
Alfa Chemistry	ACM77521	http://www.alfa-chemistry.com/search.aspx?q=ACM77521
ApexBio Technology	N1823	https://www.apexbt.com/catalogsearch/result/?q=N1823
Apollo Scientific	BIDF1012	http://www.apolloscientific.co.uk/chemical_results.php?qstext=BIDF1012&product_group=%25&search_fieldname=header_search
Apollo Scientific	BIDF1028	http://www.apolloscientific.co.uk/chemical_results.php?qstext=BIDF1028&product_group=%25&search_fieldname=header_search
AstaTech	41371	http://astatechinc.com/CPSResult.php?CRNO=41371
Biopurify Phytochemicals	BP1426	https://www.phytopurify.com/search.do?a=s&searchtype=3&psize=10&q=BP1426&searchhtmp=simplesearch&t=1
BioSynth	Q-201916	https://www.biosynth.com/en/products/life-science/other-biochemicals/products/Q-201916
BOC Sciences	220435-39-2	http://www.bocsci.com/description.asp?cas=220435-39-2
BOC Sciences	77-52-1	http://www.bocsci.com/description.asp?cas=77-52-1
Capot Chemical	5861	https://www.capotchem.com/search.do?q=5861
Cayman Chemical	10072	http://www.caymanchem.com/app/template/Product.vm/catalog/10072
Chem Scene	CS-3799	http://www.chemscene.com/goproductList/searchProductList?productObj=CS-3799
Chem4Pharma	C4PU281	https://www.chem4pharma.com/product-page/C4PU281
ChemShuttle	151658	https://www.chemshuttle.com/catalogsearch/result/?q=151658
eMolecules	110021318	https://orderbb.emolecules.com/search/#?query=110021318
eMolecules	1935013	https://orderbb.emolecules.com/search/#?query=1935013
eMolecules	26400107	https://orderbb.emolecules.com/search/#?query=26400107
eMolecules	4367330	https://orderbb.emolecules.com/search/#?query=4367330
eMolecules	532067	https://orderbb.emolecules.com/search/#?query=532067
eNovation Chemicals	D584053	https://www.enovationchem.com/Products.asp?SEARCHTEXT=D584053&searchbtn.x=0&searchbtn.y=0
Frontier Scientific Services	501002336	http://orders.frontierssi.com/fssionline32/public/product.aspx?cat=501002336&type=hts
Indofine	06-031	https://indofinechemical.com/details.aspx?Sku=06-031
KeyOrganics	GS-6617	http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=GS-6617
KeyOrganics	VS-02513	http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=VS-02513
Lab Network	LN00850329	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00850329
Lab Seeker	SC-06754	http://www.labseeker.com/search.php?keywords=SC-06754&category=0
LabSeeker	SC-06754	http://www.labseeker.com/search.php?keywords=SC-06754&category=0
Matrix Scientific	97525	http://www.matrixscientific.com/097525.html
mcule	MCULE-1308336736	https://mcule.com/MCULE-1308336736/
mcule	MCULE-9474095410	https://mcule.com/MCULE-9474095410/
MedChem Express	HY-N0140	https://www.medchemexpress.com/search.html?q=HY-N0140&ft=&fa=&fp=
MolMall	15615	http://www.molmall.net/product/15615
Molnova	M15928	https://www.molnova.com/en/serch-list.html?keywords=M15928
MolPort	MolPort-002-507-280	https://www.molport.com/shop/molecule-link/MolPort-002-507-280
MolPort	MolPort-003-939-637	https://www.molport.com/shop/molecule-link/MolPort-003-939-637
MolPort	MolPort-003-983-927	https://www.molport.com/shop/molecule-link/MolPort-003-983-927
Otava	3460065	https://search.otavachemicals.com/#!/search?query=3460065&type=code
PI Chemicals	PI-28816	http://www.pipharm.com/catalog_products/PI-28816.html
Princeton BioMolecular Research	OSSL_108153	http://www.princetonbio.com/order_online?common_id=OSSL_108153
Ryan Scientific	Thimerosal	https://ryansci.com/products?q=Thimerosal&list_q=&search_type=exact
TargetMol	BBP00038	https://www.targetmol.com/search?keyword=BBP00038
TargetMol	T0722	https://www.targetmol.com/search?keyword=T0722
Tetrahedron	TS22864	http://www.thsci.com/search.do?q=TS22864
TimTec	ST056289	http://www.echemstore.com/catalogsearch/result/?q=ST056289
Toronto Research Chemicals	U850100	https://www.trc-canada.com/product-detail/?CatNum=U850100
Vitas-M Laboratory	BBL010457	http://www.vitasmlab.biz/search/BBL010457
Vitas-M Laboratory	STL146145	http://www.vitasmlab.biz/search/STL146145

PubMed

Title	Date	PubMed
A new pentacyclic triterpenoid glucoside from Prunus serrulata var. spontanea.	2004-01	14709888
Epicuticular waxes from caatinga and cerrado species and their efficiency against water loss.	2003-12	14605678
Antiplasmodial triterpenes from twigs of Gardenia saxatilis.	2003-10	12963155
A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents.	2003-09	12871156
Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes.	2003-08-29	12969763
Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase.	2003-08-21	12926069
High-performance liquid chromatographic analysis of bioactive triterpenes in Perilla frutescens.	2003-08-21	12907261
Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.	2003-08-01	12907607
[Effects of ursolic acid on liver-protection and bile secretion].	2003-08	14649204
Sterols and triterpenes in cell culture of Hyssopus officinalis L.	2003-07-23	12872919
MECC determination of oleanolic acid and ursolic acid isomers in Ligustrum lucidum Ait.	2003-07-14	14565552
The role of hydrogen peroxide produced by polychlorinated biphenyls in PMR1-deficient yeast cells.	2003-07	12944380
In vitro TGF-beta1 antagonistic activity of ursolic and oleanolic acids isolated from Clerodendranthus spicatus.	2003-07	12898427
Immunomodulatory activities of flavonoids, monoterpenoids, triterpenoids, iridoid glycosides and phenolic compounds of Plantago species.	2003-07	12898413
Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells.	2003-07	12792782
[Chemical constituents in the roots of Salvia przewalskii Maxim].	2003-05	12958839
Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity.	2003-05	12762811
Biological activity of some naturally occurring resins, gums and pigments against in vitro LDL oxidation.	2003-05	12748987
Development of LC-MS method for determination of ursolic acid: application to the analysis of ursolic acid in Staphylea holocarpa Hemsl.	2003-04-01	12684108
New ursolic and betulinic derivatives as potential cytotoxic agents.	2003-04	12943194
Eremophilenolides and other constituents from the roots of Ligularia sagitta.	2003-04	12709904
A new in vitro tissue factor inhibitory triterpene from the fruits of Chaenomeles sinensis.	2003-04	12709899
Antifeedant activity of some pentacyclic triterpene acids and their fatty acid ester analogues.	2003-03-26	12643657
Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension.	2003-03	12725563
New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata.	2003-03	12662105
CNS activity of the methanol extract of Mallotus peltatus (Geist) Muell Arg. leaf: an ethnomedicine of Onge.	2003-03	12576208
Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves.	2003-02	12648829
In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid, from Cussonia bancoensis.	2003-02	12643591
Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea.	2003-02	12608862
Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L.	2003-02	12601674
Biomass segregation in sage cell suspension culture.	2003-01	12882308
Cytotoxic triterpenes from the twigs of Celtis philippinensis.	2003-01	12482456
Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system.	2003	13678231
The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes.	2003	12932292
Antileukemic activity of selected natural products in Taiwan.	2003	12723753
[Comparative study of the spectral characteristics of ursolic acid between laser Raman spectra and IR spectrum].	2002-12	12914177
[Determination of ursolic acid in herba of Verbena officinalis by HPLC].	2002-12	12776531
Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa.	2002-12	12514247
Antithrombin activity of some constituents from Origanum vulgare.	2002-12	12490231
Alysinol--a new triterpene from Alysicarpus monolifer.	2002-12	12462347
[Studies on chemical constituents in fruit of Eucalyptus globulus].	2002-08	12776496
[Chemical composition of fructus Liquidambaris--lulutong].	2002-04	12579820
Inhibitory activity of minor polyphenolic and nonpolyphenolic constituents of olive oil against in vitro low-density lipoprotein oxidation.	2002	12511107
[Studies on chemical constituents of Gaultheria leucocarpa var. Yunnanensis (Franch.) T. Z. Hsu & R. C. Fang].	2001-12	12776334
[HPLC determination of oleanolic acid and llrolic acid in Chinese medicinal herbs].	2001-09	12776430
[Studies on the triterpenoidal saponins from flowers of Eriobotrya japonica].	2001-06	12600109
[Isolation and elucidation of chemical constituents of Shandanshaoyao Decoction(I)].	2001-06	12528509
[Lipid chemical constituents of Salvia sochifolia C. Y. Wu].	2001-04	12525052
[The research on the chemical components of Schizonepeta tenuifolia Briq].	2001-03	12587173
Oleanolic acid from cranberries.	1953-10	13096399

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:23:16 GMT 2025` Edited by `admin` on `Mon Mar 31 19:23:16 GMT 2025`
Record UNII	P3M2575F3F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

URSOLIC ACID

Official Name

English

NSC-167406

Preferred Name

English

URS-12-EN-28-OIC ACID, 3-HYDROXY-, (3.BETA.)-

Common Name

English

NSC-4060

Code

English

URSOLIC ACID [MI]

Common Name

English

PRUNOL

Common Name

English

Ursolic acid [WHO-DD]

Common Name

English

URSOLIC ACID (CONSTITUENT OF HOLY BASIL LEAF) [DSC]

Common Name

English

MICROMEROL

Common Name

English

URSON

Common Name

English

(3.BETA.)-3-HYDROXYURS-12-EN-28-OIC ACID

Common Name

English

URSOLIC ACID [USP-RS]

Common Name

English

URSOLIC ACID [HSDB]

Common Name

English

MALOL

Common Name

English

Classification Tree Code System Code

DSLD

2413 (Number of products:7)