SODIUM URSOLATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C30H47O3.Na
Molecular Weight	478.6821
Optical Activity	UNSPECIFIED
Defined Stereocenters	10 / 10
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C)C([O-])=O)[C@@]1(C)CC[C@H](O)C2(C)C

InChI

InChIKey=DUAZSEDLBBRXQJ-ANQQBNRBSA-M

InChI=1S/C30H48O3.Na/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7;/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33);/q;+1/p-1/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C30H47O3
Molecular Weight	455.6924
Charge	-1
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	10 / 10
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://korea.in-cosmetics.com/en/Exhibitors/2695677/GfN-GmbH-Selco-GmbH/Products/1138708/Ursolic-acid-Na-salt-natural | https://www.ulprospector.com/en/na/PersonalCare/Detail/6837/373852/Ursolic-Acid-Sodium-Salt-Salvia-Officinalis-Extracthttps://examine.com/supplements/ursolic-acid/
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/24374755 | https://www.ncbi.nlm.nih.gov/pubmed/23499879 | https://www.ncbi.nlm.nih.gov/pubmed/26610440 | https://www.ncbi.nlm.nih.gov/pubmed/26775565

Ursolic acid is a natural terpene compond found in a wide variety of plants but most well known for being in apple peels. Ursolic acid has a series of biological effects such as sedative, anti-inflammatory, anti-bacterial, anti-diabetic, antiulcer, antitumor etc. Ursolic acid has been shown to target multiple proinflammatory transcription factors, cell cycle proteins, growth factors, kinases, cytokines, chemokines, adhesion molecules, and inflammatory enzymes. Evidences suggest that ursolic acid could be used as a potential candidate to develop a comprehensive competent strategy towards the treatment and prevention of health disorders. Although the science is preliminary, it seems to be able to reduce fat accumulation and increase muscle mass gain when in a fed state, and to induce fat burning and preserve muscle mass when in a fasted state.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
protein folding 2 Target ID: GO:0006457 Sources: https://www.ulprospector.com/en/na/PersonalCare/Detail/6837/373852/Ursolic-Acid-Sodium-Salt-Salvia-Officinalis-Extract	Modulator 817
collagen biosynthetic process 3 Target ID: GO:0032964 Sources: https://www.ulprospector.com/en/na/PersonalCare/Detail/6837/373852/Ursolic-Acid-Sodium-Salt-Salvia-Officinalis-Extract	Activator 1404
Target ID: Elastase Sources: http://korea.in-cosmetics.com/en/Exhibitors/2695677/GfN-GmbH-Selco-GmbH/Products/1138708/Ursolic-acid-Na-salt-natural	Inhibitor 8146
response to oxidative stress 20 Target ID: GO:0006979 Sources: https://www.ulprospector.com/en/na/PersonalCare/Detail/604/640714/Sodium-Ursolate	Modulator 817
Platelet glycoprotein 4 3 Target ID: CHEMBL1744526 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17404266/	Interacts 314
Cytochrome P450 19A1 37 Target ID: CHEMBL1978 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18192087	Inhibitor 8146	32.0 µM [IC50]
Aldose reductase 44 Target ID: CHEMBL1900 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22332359	Inhibitor 8146
Protein-tyrosine phosphatase 1B 33 Target ID: CHEMBL335 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16534732	Inhibitor 8146	3.8 µM [IC50]
11-beta-hydroxysteroid dehydrogenase 1 21 Target ID: CHEMBL4235 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20100662	Inhibitor 8146

Conditions

Condition	Modality	Highest Phase	Product
Photoaging of skin 4 Sources: https://www.ulprospector.com/en/eu/PersonalCare/Detail/3345/93891/Ursolic-Acid-Sodium-Salt https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=27ced99b-59a5-473f-90c5-f72b7e48ebdc&type=pdf&name=27ced99b-59a5-473f-90c5-f72b7e48ebdc	Inactive ingredient	Not Provided 505	PREVENTAGE FIRMING DEFENSE NORMAL/OILY BROAD SPECTRUM SPF 15 MERLE NORMAN Approved Use Unknown
Sarcopenia 3 Sources: https://examine.com/supplements/ursolic-acid	Primary	Phase III 651	Unknown Approved Use Unknown
Metabolic syndrome 32 Sources: https://examine.com/supplements/ursolic-acid	Primary	Phase II 1133	Unknown Approved Use Unknown
Male fertility 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15854639 DOI: 10.1002/(SICI)1099-1573(19980201)12:1<32::AID-PTR185>3.0.CO;2-4 https://examine.com/supplements/ursolic-acid/#ref63	Preventing	Preclinical	Unknown Approved Use Unknown
Cancer 581 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24374755 https://www.ncbi.nlm.nih.gov/pubmed/23499879	Primary	Preclinical	Unknown Approved Use Unknown
Inflammation 101 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18812028/	Primary	Preclinical	Unknown Approved Use Unknown

C_max

Value	Dose	Analyte	Population
1835 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	37 mg/m² single, intravenous dose: 37 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
2865 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	74 mg/m² single, intravenous dose: 74 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3457 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	98 mg/m² single, intravenous dose: 98 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1211 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	74 mg/m² 1 times / day multiple, intravenous dose: 74 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
4203 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	37 mg/m² single, intravenous dose: 37 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
7175 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	74 mg/m² single, intravenous dose: 74 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
9696 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	98 mg/m² single, intravenous dose: 98 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4834 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	74 mg/m² 1 times / day multiple, intravenous dose: 74 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
4.59 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	37 mg/m² single, intravenous dose: 37 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
4.46 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	74 mg/m² single, intravenous dose: 74 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3.9 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	98 mg/m² single, intravenous dose: 98 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/23319864	74 mg/m² 1 times / day multiple, intravenous dose: 74 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	URSOLIC ACID plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
130 mg/m2 single, intravenous (total daily dose) Highest studied dose Dose: 130 mg/m2 Route: intravenous Route: single Dose: 130 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy n = 3 Health Status: unhealthy Condition: solid tumors Sex: M Food Status: UNKNOWN Population Size: 3 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	DLT: ALT increased, AST increased... Other AEs: GGT increased... Dose limiting toxicities: ALT increased (grade 3, 2 patients) AST increased (grade 3, 2 patients) Direct bilirubin increased (grade 3, 2 patients) Other AEs: GGT increased (grade 2, 2 patients) Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
94 mg/m2 single, intravenous (unknown) MTD Dose: 94 mg/m2 Route: intravenous Route: single Dose: 94 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy n = 11 Health Status: unhealthy Condition: solid tumors Sex: M+F Food Status: UNKNOWN Population Size: 11 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	DLT: ALT increased, GGT increased... Other AEs: AST increased... Dose limiting toxicities: ALT increased (grade 3, 1 pt) GGT increased (grade 3, 1 pt) Other AEs: AST increased (grade 2, 2 patients) Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
74 mg/m2 single, intravenous (unknown) Studied dose Dose: 74 mg/m2 Route: intravenous Route: single Dose: 74 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy n = 6 Health Status: unhealthy Condition: solid tumor Sex: M+F Food Status: UNKNOWN Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	DLT: AST increased, ALT increased... Dose limiting toxicities: AST increased (grade 3, 1 pt) ALT increased (grade 3, 1 pt) diarrhea (grade 3, 1 pt) Sources: https://pubmed.ncbi.nlm.nih.gov/23134084

AEs

AE	Significance	Dose	Population
GGT increased	grade 2, 2 patients	130 mg/m2 single, intravenous (total daily dose) Highest studied dose Dose: 130 mg/m2 Route: intravenous Route: single Dose: 130 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy n = 3 Health Status: unhealthy Condition: solid tumors Sex: M Food Status: UNKNOWN Population Size: 3 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
ALT increased	grade 3, 2 patients DLT	130 mg/m2 single, intravenous (total daily dose) Highest studied dose Dose: 130 mg/m2 Route: intravenous Route: single Dose: 130 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy n = 3 Health Status: unhealthy Condition: solid tumors Sex: M Food Status: UNKNOWN Population Size: 3 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
AST increased	grade 3, 2 patients DLT	130 mg/m2 single, intravenous (total daily dose) Highest studied dose Dose: 130 mg/m2 Route: intravenous Route: single Dose: 130 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy n = 3 Health Status: unhealthy Condition: solid tumors Sex: M Food Status: UNKNOWN Population Size: 3 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
Direct bilirubin increased	grade 3, 2 patients DLT	130 mg/m2 single, intravenous (total daily dose) Highest studied dose Dose: 130 mg/m2 Route: intravenous Route: single Dose: 130 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy n = 3 Health Status: unhealthy Condition: solid tumors Sex: M Food Status: UNKNOWN Population Size: 3 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
AST increased	grade 2, 2 patients	94 mg/m2 single, intravenous (unknown) MTD Dose: 94 mg/m2 Route: intravenous Route: single Dose: 94 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy n = 11 Health Status: unhealthy Condition: solid tumors Sex: M+F Food Status: UNKNOWN Population Size: 11 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
ALT increased	grade 3, 1 pt DLT	94 mg/m2 single, intravenous (unknown) MTD Dose: 94 mg/m2 Route: intravenous Route: single Dose: 94 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy n = 11 Health Status: unhealthy Condition: solid tumors Sex: M+F Food Status: UNKNOWN Population Size: 11 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
GGT increased	grade 3, 1 pt DLT	94 mg/m2 single, intravenous (unknown) MTD Dose: 94 mg/m2 Route: intravenous Route: single Dose: 94 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy n = 11 Health Status: unhealthy Condition: solid tumors Sex: M+F Food Status: UNKNOWN Population Size: 11 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
ALT increased	grade 3, 1 pt DLT	74 mg/m2 single, intravenous (unknown) Studied dose Dose: 74 mg/m2 Route: intravenous Route: single Dose: 74 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy n = 6 Health Status: unhealthy Condition: solid tumor Sex: M+F Food Status: UNKNOWN Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
AST increased	grade 3, 1 pt DLT	74 mg/m2 single, intravenous (unknown) Studied dose Dose: 74 mg/m2 Route: intravenous Route: single Dose: 74 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy n = 6 Health Status: unhealthy Condition: solid tumor Sex: M+F Food Status: UNKNOWN Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084
diarrhea	grade 3, 1 pt DLT	74 mg/m2 single, intravenous (unknown) Studied dose Dose: 74 mg/m2 Route: intravenous Route: single Dose: 74 mg/m2 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084	unhealthy n = 6 Health Status: unhealthy Condition: solid tumor Sex: M+F Food Status: UNKNOWN Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/23134084

Sourcing

Vendor/Aggregator	ID	URL
1PlusChem LLC	1P003694	https://www.1pchem.com/search?query=1P003694
A2B Chem	AB47272	http://a2bchem.com/prod/AB47272
Accela ChemBio Inc	SY036316	http://accelachem.com/cn/search.html?keyword=SY036316&attname=0
Alfa Chemistry	ACM77521	http://www.alfa-chemistry.com/search.aspx?q=ACM77521
ApexBio Technology	N1823	https://www.apexbt.com/catalogsearch/result/?q=N1823
Apollo Scientific	BIDF1012	http://www.apolloscientific.co.uk/chemical_results.php?qstext=BIDF1012&product_group=%25&search_fieldname=header_search
Apollo Scientific	BIDF1028	http://www.apolloscientific.co.uk/chemical_results.php?qstext=BIDF1028&product_group=%25&search_fieldname=header_search
AstaTech	41371	http://astatechinc.com/CPSResult.php?CRNO=41371
BOC Sciences	220435-39-2	http://www.bocsci.com/description.asp?cas=220435-39-2
BOC Sciences	77-52-1	http://www.bocsci.com/description.asp?cas=77-52-1
BioSynth	Q-201916	https://www.biosynth.com/en/products/life-science/other-biochemicals/products/Q-201916
Biopurify Phytochemicals	BP1426	https://www.phytopurify.com/search.do?a=s&searchtype=3&psize=10&q=BP1426&searchhtmp=simplesearch&t=1
Capot Chemical	5861	https://www.capotchem.com/search.do?q=5861
Cayman Chemical	10072	http://www.caymanchem.com/app/template/Product.vm/catalog/10072
Chem Scene	CS-3799	http://www.chemscene.com/goproductList/searchProductList?productObj=CS-3799
Chem4Pharma	C4PU281	https://www.chem4pharma.com/product-page/C4PU281
ChemShuttle	151658	https://www.chemshuttle.com/catalogsearch/result/?q=151658
Frontier Scientific Services	501002336	http://orders.frontierssi.com/fssionline32/public/product.aspx?cat=501002336&type=hts
Indofine	06-031	https://indofinechemical.com/details.aspx?Sku=06-031
KeyOrganics	GS-6617	http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=GS-6617
KeyOrganics	VS-02513	http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=VS-02513
Lab Network	LN00850329	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00850329
Lab Seeker	SC-06754	http://www.labseeker.com/search.php?keywords=SC-06754&category=0
LabSeeker	SC-06754	http://www.labseeker.com/search.php?keywords=SC-06754&category=0
Matrix Scientific	97525	http://www.matrixscientific.com/097525.html
MedChem Express	HY-N0140	https://www.medchemexpress.com/search.html?q=HY-N0140&ft=&fa=&fp=
MolMall	15615	http://www.molmall.net/product/15615
MolPort	MolPort-002-507-280	https://www.molport.com/shop/molecule-link/MolPort-002-507-280
MolPort	MolPort-003-939-637	https://www.molport.com/shop/molecule-link/MolPort-003-939-637
MolPort	MolPort-003-983-927	https://www.molport.com/shop/molecule-link/MolPort-003-983-927
Molnova	M15928	https://www.molnova.com/en/serch-list.html?keywords=M15928
Otava	3460065	https://search.otavachemicals.com/#!/search?query=3460065&type=code
PI Chemicals	PI-28816	http://www.pipharm.com/catalog_products/PI-28816.html
Princeton BioMolecular Research	OSSL_108153	http://www.princetonbio.com/order_online?common_id=OSSL_108153
Ryan Scientific	Thimerosal	https://ryansci.com/products?q=Thimerosal&list_q=&search_type=exact
TargetMol	BBP00038	https://www.targetmol.com/search?keyword=BBP00038
TargetMol	T0722	https://www.targetmol.com/search?keyword=T0722
Tetrahedron	TS22864	http://www.thsci.com/search.do?q=TS22864
TimTec	ST056289	http://www.echemstore.com/catalogsearch/result/?q=ST056289
Toronto Research Chemicals	U850100	https://www.trc-canada.com/product-detail/?CatNum=U850100
Vitas-M Laboratory	BBL010457	http://www.vitasmlab.biz/search/BBL010457
Vitas-M Laboratory	STL146145	http://www.vitasmlab.biz/search/STL146145
eMolecules	110021318	https://orderbb.emolecules.com/search/#?query=110021318
eMolecules	1935013	https://orderbb.emolecules.com/search/#?query=1935013
eMolecules	26400107	https://orderbb.emolecules.com/search/#?query=26400107
eMolecules	4367330	https://orderbb.emolecules.com/search/#?query=4367330
eMolecules	532067	https://orderbb.emolecules.com/search/#?query=532067
eNovation Chemicals	D584053	https://www.enovationchem.com/Products.asp?SEARCHTEXT=D584053&searchbtn.x=0&searchbtn.y=0
mcule	MCULE-1308336736	https://mcule.com/MCULE-1308336736/
mcule	MCULE-9474095410	https://mcule.com/MCULE-9474095410/

PubMed

Title	Date	PubMed
Oleanolic acid from cranberries.	1953 Oct	13096399
Topical anti-inflammatory activity of Thymus willdenowii.	2001 Dec	11804395
Proposed active constituents of Dipladenia martiana.	2001 Dec	11746866
Ursolic acid enhances nitric oxide and tumor necrosis factor-alpha production via nuclear factor-kappaB activation in the resting macrophages.	2001 Dec 7	11741581
[Studies on the triterpenoidal saponins from flowers of Eriobotrya japonica].	2001 Jun	12600109
[The research on the chemical components of Schizonepeta tenuifolia Briq].	2001 Mar	12587173
Triterpenes and sterols in the flowers and leaves of Prunus spinosa L. (Rosaceae).	2001 Nov-Dec	12197619
Influence of the parasite Viscum cruciatum Sieber on the chemical constituents of Crataegus monogyna Jacq.	2001 Nov-Dec	11837662
[HPLC determination of oleanolic acid and llrolic acid in Chinese medicinal herbs].	2001 Sep	12776430
Activation of caspase-3 protease during the process of ursolic acid and its derivative-induced apoptosis.	2001 Sep-Oct	11848513
[Chemical composition of fructus Liquidambaris--lulutong].	2002 Apr	12579820
[Studies on chemical constituents in fruit of Eucalyptus globulus].	2002 Aug	12776496
Partial synthesis of 23-hydroxyursolic acid isolated from medicinal plants of the Rubiaceae family.	2002 Aug	12168764
[Determination of ursolic acid in herba of Verbena officinalis by HPLC].	2002 Dec	12776531
Antithrombin activity of some constituents from Origanum vulgare.	2002 Dec	12490231
Alysinol--a new triterpene from Alysicarpus monolifer.	2002 Dec	12462347
Triterpenes and saponins from Ilex psammophila.	2002 Dec	12462345
Quinovic acid glycosides from Mitragyna stipulosa--first examples of natural inhibitors of snake venom phosphodiesterase I.	2002 Dec	12462343
Abietane diterpenoids and triterpenoic acids from Salvia cilicica and their antileishmanial activities.	2002 Dec	12453510
Constituents of Gnetum montanum.	2002 Feb	11864762
Production of bioactive triterpenes by Eriobotrya japonica calli.	2002 Feb	11830140
Ursolic acid of Origanum majorana L. reduces Abeta-induced oxidative injury.	2002 Feb 28	11911474
Liposome-encapsulated ursolic acid increases ceramides and collagen in human skin cells.	2002 Jan	11876525
New prenylated benzoic acid and other constituents from almond hulls (Prunus amygdalus Batsch).	2002 Jan 30	11804537
Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15.	2002 Jun	12046077
Microbial transformation of cadina-4,10(15)-dien-3-one, aromadendr-1(10)-en-9-one and methyl ursolate by Mucor plumbeus ATCC 4740.	2002 Mar	11853742
Phosphoinositide 3-OH kinase/protein kinase B inhibits apoptotic cell death induced by reactive oxygen species in Saccharomyces cerevisiae.	2002 May	11983076
Synthesis of combinatorial libraries based on terpenoid scaffolds.	2002 May	11966432
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.	2002 Nov	12444669
Ursolic acid as a trypanocidal constituent in rosemary.	2002 Nov	12419966
Brine shrimp lethality of the compounds from Phryma leptostachya L.	2002 Oct	12433200
Sessiline, a new nitrogenous compound from the fruits of Acanthopanax sessiliflorus.	2002 Oct	12391563
Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata.	2002 Oct	12391557
Antimicrobial and anti-inflammatory activity of folklore: Mallotus peltatus leaf extract.	2002 Oct	12242000
Extract and identify ingredient from Ligustrum Lucidum Ait and study its effect to periodontal pathogen.	2002 Sep	12425858
Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system.	2003	13678231
A new in vitro tissue factor inhibitory triterpene from the fruits of Chaenomeles sinensis.	2003 Apr	12709899
Development of LC-MS method for determination of ursolic acid: application to the analysis of ursolic acid in Staphylea holocarpa Hemsl.	2003 Apr 1	12684108
[Effects of ursolic acid on liver-protection and bile secretion].	2003 Aug	14649204
Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes.	2003 Aug 29	12969763
Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves.	2003 Feb	12648829
Biomass segregation in sage cell suspension culture.	2003 Jan	12882308
The role of hydrogen peroxide produced by polychlorinated biphenyls in PMR1-deficient yeast cells.	2003 Jul	12944380
Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells.	2003 Jul	12792782
Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase.	2003 Jul-Aug	12926069
CNS activity of the methanol extract of Mallotus peltatus (Geist) Muell Arg. leaf: an ethnomedicine of Onge.	2003 Mar	12576208
Antifeedant activity of some pentacyclic triterpene acids and their fatty acid ester analogues.	2003 Mar 26	12643657
Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity.	2003 May	12762811
Sterols and triterpenes in cell culture of Hyssopus officinalis L.	2003 May-Jun	12872919
A new pentacyclic triterpenoid glucoside from Prunus serrulata var. spontanea.	2004 Jan	14709888

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

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Substance Class	Chemical Created by `admin` on `Sat Dec 17 12:54:03 UTC 2022` Edited by `admin` on `Sat Dec 17 12:54:03 UTC 2022`
Record UNII	NV5D25VL1O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM URSOLATE

Official Name

English

URS-12-EN-28-OIC ACID, 3-HYDROXY-, SODIUM SALT (1:1), (3.BETA.)-

Common Name

English

URS-12-3EN-28-OIC ACID, 3-HYDROXY-, MONOSODIUM SALT, (3-.BETA.)-

Common Name

English

SODIUM URSOLATE [INCI]

Common Name

English

DUBOISIA URSOLIC ACID, SODIUM SALT, PREMIER

Brand Name

English

Code System Code Type Description

PUBCHEM

71587647