DECOQUINATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H35NO5
Molecular Weight	417.5384
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCOC1=CC2=C(O)C(=CN=C2C=C1OCC)C(=O)OCC

InChI

InChIKey=JHAYEQICABJSTP-UHFFFAOYSA-N

InChI=1S/C24H35NO5/c1-4-7-8-9-10-11-12-13-14-30-21-15-18-20(16-22(21)28-5-2)25-17-19(23(18)26)24(27)29-6-3/h15-17H,4-14H2,1-3H3,(H,25,26)

HIDE SMILES / InChI

Molecular Formula	C24H35NO5
Molecular Weight	417.5384
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.efsa.europa.eu/sites/default/files/scientific_output/files/main_documents/17.pdf

Decoquinate is a quinolone derivative that is used in the control of coccidiosis in domestic animals. Decoquinate treats and prevents coccidiosis in chickens, cattle, goats, sheep, etc. Decoquinate acts on sporozoites development and prevents their penetration of the gut epithelium. Decoquinate inhibits mitochondrial respiration and electron transport in Eimeria.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Development of sporozoites 1 Target ID: Development of sporozoites Sources: http://www.efsa.europa.eu/sites/default/files/scientific_output/files/main_documents/17.pdf	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Coccidiosis 45 Sources: http://www.fda.gov/ohrms/dockets/98fr/141060Fi.pdf	Preventing		Approved 8583	DECCOX Approved Use For the prevention of coccidiosis. Launch Date 1999

PubMed

Title	Date	PubMed
Nanoparticle formulations of decoquinate increase antimalarial efficacy against liver stage Plasmodium infections in mice.	2014-01	23891618
In vitro determination of anticryptosporidial activity of phytogenic extracts and compounds.	2012-07	22278729
Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug.	2012-04-15	22396598
Multi-residue method for detecting coccidiostats at carry-over level in feed by HPLC-MS/MS.	2010-06	20198524
Multi-residue confirmatory method for the determination of twelve coccidiostats in chicken liver using liquid chromatography tandem mass spectrometry.	2009-11-13	19481216
Giardia duodenalis in feedlot cattle from the central and western United States.	2009-10-02	19799795
Oral pharmacokinetics and milk residues of decoquinate in milking cows.	2009-08	19614848
Use of GenMAPP and MAPPFinder to analyse pathways involved in chickens infected with the protozoan parasite Eimeria.	2009-07-16	19615120
Supply of Deccox 25 Individual Treatment Packs.	2009-03-21	19305017
Determination of decoquinate in animal feeds by liquid chromatography: collaborative study.	2008-08-30	18727525
Ovine toxoplasmosis: transmission, clinical outcome and control.	2007-12	18689230
Efficacy of decoquinate against drug sensitive laboratory strains of Eimeria tenella and field isolates of Eimeria spp. in broiler chickens in China.	2007-07-20	17485176
Effect of the quinolone coccidiostat decoquinate on the rearrangement of chromosomes of Eimeria tenella.	2006-12	17005184
Field study of the efficacy of halofuginone and decoquinate in the treatment of cryptosporidiosis in veal calves.	2006-11-11	17099176
An Irish perspective on Cryptosporidium. Part 2.	2006-09-01	21851686
Relative virulences of a drug-resistant and a drug-sensitive strain of Eimeria acervulina, a coccidium of chickens.	2006-01-15	16361061
Tracing the emergence of drug-resistance in coccidia (Eimeria spp.) of commercial broiler flocks medicated with decoquinate for the first time in the United Kingdom.	2006-01-15	16289564
Effect of different decoquinate treatments on cryptosporidiosis in naturally infected cashmere goat kids.	2005-08-27	16127138
Questions limitation in treatment of hepatozoonosis.	2005-06-15	15989174
Prophylactic use of decoquinate for infections with Cryptosporidium parvum in experimentally challenged neonatal calves.	2003-09-15	14507102
Efficacy of selected oral chemotherapeutants against Ichthyophthirius multifiliis (Ciliophora: Ophyroglenidae) infecting rainbow trout Oncorhynchus mykiss.	2003-06-20	12887250
Treatment of dogs infected with Hepatozoon americanum: 53 cases (1989-1998).	2001-01-01	11149719
Activity of decoquinate against Cryptosporidium parvum in cell cultures and neonatal mice.	2000-05-17	10799844
Decoquinate induces tissue cyst formation by the RH strain of Toxoplasma gondii.	1998-06-15	9746277
Mutants of Toxoplasma gondii resistant to atovaquone (566C80) or decoquinate.	1993-08	8331476

Patents

Sample Use Guides

In Vivo Use Guide

22.7 mg/100 lb of body weight (0.5 mg/kg) per day (cattle, goats, sheep) or 0.003% (chicken). Feed for at least 28 days during periods of coccidiosis exposure or when experience indicates that coccidiosis is likely to be a hazard.

Route of Administration: Intragastric

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:37:04 GMT 2025` Edited by `admin` on `Mon Mar 31 17:37:04 GMT 2025`
Record UNII	534I52PVWH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DECCOX

Preferred Name

English

DECOQUINATE

Official Name

English

M&B 15497

Code

English

HC 1528

Code

English

M&B-15497

Code

English

decoquinate [INN]

Common Name

English

DECOQUINATE [USAN]

Common Name

English

3-QUINOLINECARBOXYLIC ACID, 6-(DECYLOXY)-7-ETHOXY-4-HYDROXY-, ETHYL ESTER

Common Name

English

DECOQUINATE [MI]

Common Name

English

DECOQUINATE [USP MONOGRAPH]

Common Name

English

NSC-339057

Code

English

DECOQUINATE [USP-RS]

Common Name

English

Ethyl 6-(decyloxy)-7-ethoxy-4-hydroxy-3-quinolinecarboxylate

Systematic Name

English

DECOQUINATE [GREEN BOOK]

Common Name

English

HC-1528

Code

English

DECOQUINATE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C795