DECOQUINATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H35NO5
Molecular Weight	417.5384
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCOC1=CC2=C(O)C(=CN=C2C=C1OCC)C(=O)OCC

InChI

InChIKey=JHAYEQICABJSTP-UHFFFAOYSA-N

InChI=1S/C24H35NO5/c1-4-7-8-9-10-11-12-13-14-30-21-15-18-20(16-22(21)28-5-2)25-17-19(23(18)26)24(27)29-6-3/h15-17H,4-14H2,1-3H3,(H,25,26)

HIDE SMILES / InChI

Molecular Formula	C24H35NO5
Molecular Weight	417.5384
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.efsa.europa.eu/sites/default/files/scientific_output/files/main_documents/17.pdf

Decoquinate is a quinolone derivative that is used in the control of coccidiosis in domestic animals. Decoquinate treats and prevents coccidiosis in chickens, cattle, goats, sheep, etc. Decoquinate acts on sporozoites development and prevents their penetration of the gut epithelium. Decoquinate inhibits mitochondrial respiration and electron transport in Eimeria.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Development of sporozoites 1 Target ID: Development of sporozoites Sources: http://www.efsa.europa.eu/sites/default/files/scientific_output/files/main_documents/17.pdf	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Coccidiosis 45 Sources: http://www.fda.gov/ohrms/dockets/98fr/141060Fi.pdf	Preventing		Approved 8429	DECCOX Approved Use For the prevention of coccidiosis. Launch Date 1999

PubMed

Title	Date	PubMed
Decoquinate induces tissue cyst formation by the RH strain of Toxoplasma gondii.	1998 Jun 15	9746277
Treatment of dogs infected with Hepatozoon americanum: 53 cases (1989-1998).	2001 Jan 1	11149719
Efficacy of selected oral chemotherapeutants against Ichthyophthirius multifiliis (Ciliophora: Ophyroglenidae) infecting rainbow trout Oncorhynchus mykiss.	2003 Jun 20	12887250
Effect of the quinolone coccidiostat decoquinate on the rearrangement of chromosomes of Eimeria tenella.	2006 Dec	17005184
Relative virulences of a drug-resistant and a drug-sensitive strain of Eimeria acervulina, a coccidium of chickens.	2006 Jan 15	16361061
Tracing the emergence of drug-resistance in coccidia (Eimeria spp.) of commercial broiler flocks medicated with decoquinate for the first time in the United Kingdom.	2006 Jan 15	16289564
Field study of the efficacy of halofuginone and decoquinate in the treatment of cryptosporidiosis in veal calves.	2006 Nov 11	17099176
An Irish perspective on Cryptosporidium. Part 2.	2006 Sep 1	21851686
Oral pharmacokinetics and milk residues of decoquinate in milking cows.	2009 Aug	19614848
Multi-residue confirmatory method for the determination of twelve coccidiostats in chicken liver using liquid chromatography tandem mass spectrometry.	2009 Nov 13	19481216
Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug.	2012 Apr 15	22396598
In vitro determination of anticryptosporidial activity of phytogenic extracts and compounds.	2012 Jul	22278729
Nanoparticle formulations of decoquinate increase antimalarial efficacy against liver stage Plasmodium infections in mice.	2014 Jan	23891618

Patents

Sample Use Guides

In Vivo Use Guide

22.7 mg/100 lb of body weight (0.5 mg/kg) per day (cattle, goats, sheep) or 0.003% (chicken). Feed for at least 28 days during periods of coccidiosis exposure or when experience indicates that coccidiosis is likely to be a hazard.

Route of Administration: Intragastric

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:03:28 GMT 2023` Edited by `admin` on `Fri Dec 15 15:03:28 GMT 2023`
Record UNII	534I52PVWH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DECOQUINATE

Official Name

English

M&B 15497

Code

English

HC 1528

Code

English

DECCOX

Brand Name

English

M&B-15497

Code

English

decoquinate [INN]

Common Name

English

DECOQUINATE [USAN]

Common Name

English

3-QUINOLINECARBOXYLIC ACID, 6-(DECYLOXY)-7-ETHOXY-4-HYDROXY-, ETHYL ESTER

Common Name

English

DECOQUINATE [MI]

Common Name

English

DECOQUINATE [USP MONOGRAPH]

Common Name

English

NSC-339057

Code

English

DECOQUINATE [USP-RS]

Common Name

English

Ethyl 6-(decyloxy)-7-ethoxy-4-hydroxy-3-quinolinecarboxylate

Systematic Name

English

DECOQUINATE [GREEN BOOK]

Common Name

English

HC-1528

Code

English

DECOQUINATE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C795