Dosergoside is ergot alkaloid derivative. It was developed as dopaminergic agent.

Pimetine has been reported to be an antiatherogenic agent of particular interest since its activities are unrelated to blood cholesterol levels. Pimetine hydrochloride (IN 379) alters the production and utilization of acid mucopolysaeeharides and may block the formation of atherosclerotic plaque. The initial clinical evaluation of pimetine in neuropsychiatric disorders was performed in hospitalized patients with the diagnosis of "chronic brain syndrome". Behavioral effects of pimetine were increased alertness, interest and sociability with improvement in organization of thought processes. In patients suffering from chronic organic diseases, pimetine was reported to produce a feeling of "more energy", a general feeling of "well being" and mild insomnia was reported as a non-limiting side effect. Pimetine was found to be a less active stimulant than amphetamine.

Stibosamine is a Salts of p-aminophenylstibinic acid and N-ethylethanamine patented by Hynson, Westcott & Dunning for the treatment kala-azar infection.

Orpanoxin (previously known as F-776), a nonsteroidal anti-inflammatory drug that was developed as an analgesic agent. Orpanoxin is a prostaglandin synthetase inhibitor and may have a potential for the treatment of rheumatic. However, information about the current development of this drug is not available.

Cyprolidol is a pyridylcyclopropane derivative, developed by Neisler Laboratories. In animal models, cyprolidol produced an antidepressant effect qualitatively similar to those produced by imipramine. The compound blocked the tyramine-induced rise in blood pressure only in anesthetized dogs but potentiated it in conscious dogs. In man, cyprolidol was less effective than imipramine.

LEDOXANTRONE, a benzothiopyranoindazole, is an intercalating agent. Its mechanism of action is probably due to DNA helicase blockade. It was under development for the treatment of prostate and ovarian cancers.

Mergocriptine (2-methyl-a-ergocryptine or CBM36-733) is a synthetic long-acting ergot derivative. It exerts agonistic action at dopamine receptors. Mergocryptine may induce the suppression of striatal dopamine turnover by reducing dopamine release via the stimulation of presynaptic dopaminergic autoreceptors. In animal experiments, it may affect cerebral hemodynamics. Mergocriptine has a protective effect on the brain against ischemia.

L-MTX is a second-generation tau protein aggregation inhibitor. It acts by reducing levels of aggregated or misfolded tau proteins, which are associated with the progressive neurodegeneration. It is currently under development for the treatment of Alzheimer’s disease.

Rumenic acid is the major conjugated linoleic acid (CLA), probably because of successive desaturation and chain elongation and can be considered as the principal dietary form. In experiments on rodents was shown that rumenic acid possessed the protective effect against colitis, which was associated with the activation of the Nrf2 pathway.