MERGOCRIPTINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C33H43N5O5
Molecular Weight	589.725
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@H]3CN(C)[C@@H]4CC5=C(C)NC6=C5C(=CC=C6)C4=C3)(O[C@@]2(O)[C@@H]7CCCN7C1=O)C(C)C

InChI

InChIKey=AFFLEALSHYGOOD-NOURLPFCSA-N

InChI=1S/C33H43N5O5/c1-17(2)13-26-30(40)37-12-8-11-27(37)33(42)38(26)31(41)32(43-33,18(3)4)35-29(39)20-14-23-21-9-7-10-24-28(21)22(19(5)34-24)15-25(23)36(6)16-20/h7,9-10,14,17-18,20,25-27,34,42H,8,11-13,15-16H2,1-6H3,(H,35,39)/t20-,25-,26+,27+,32-,33+/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2077182 | https://www.ncbi.nlm.nih.gov/pubmed/1418053 | https://www.ncbi.nlm.nih.gov/pubmed/1841037 | https://www.ncbi.nlm.nih.gov/pubmed/1864302

Mergocriptine (2-methyl-a-ergocryptine or CBM36-733) is a synthetic long-acting ergot derivative. It exerts agonistic action at dopamine receptors. Mergocryptine may induce the suppression of striatal dopamine turnover by reducing dopamine release via the stimulation of presynaptic dopaminergic autoreceptors. In animal experiments, it may affect cerebral hemodynamics. Mergocriptine has a protective effect on the brain against ischemia.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Effects of mergocriptine on cerebral circulation and metabolism in cats.	1992-07	1418053
Effects of chronic administration of mergocryptine on changes in neurotransmitter levels in the ischemic gerbil brain.	1990-11-01	1983063

Patents

Name

Type

Language

MERGOCRIPTINE

Official Name

English

2-METHYL-.ALPHA.-ERGOCRYPTINE

Preferred Name

English

mergocriptine [INN]

Common Name

English

CBM36-733

Common Name

English

CBM 36-733

Common Name

English

Code System Code Type Description

PUBCHEM

54803