Hydromethylthionine

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H19N3S
Molecular Weight	285.407
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)C1=CC2=C(NC3=C(S2)C=C(C=C3)N(C)C)C=C1

InChI

InChIKey=QTWZICCBKBYHDM-UHFFFAOYSA-N

InChI=1S/C16H19N3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13/h5-10,17H,1-4H3

HIDE SMILES / InChI

Molecular Formula	C16H19N3S
Molecular Weight	285.407
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://taurx.com/lmtx-for-alzheimers.html | https://clinicaltrials.gov/ct2/show/NCT03446001 | https://www.ncbi.nlm.nih.gov/pubmed/25759392

L-MTX is a second-generation tau protein aggregation inhibitor. It acts by reducing levels of aggregated or misfolded tau proteins, which are associated with the progressive neurodegeneration. It is currently under development for the treatment of Alzheimer’s disease.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Tau protein aggregation 3 Target ID: Tau protein aggregation Sources: https://www.ncbi.nlm.nih.gov/pubmed/26809554\|http://taurx.com/lmtx-for-alzheimers.html\|https://www.ncbi.nlm.nih.gov/pubmed/25759392	Inhibitor 8504		0.12 µM [Ki]

PubMed

Title	Date	PubMed
Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial.	2016-12-10	27863809
Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease.	2015-04-24	25759392
Tau-aggregation inhibitor therapy for Alzheimer's disease.	2014-04-15	24361915

Patents

Sample Use Guides

In Vivo Use Guide

L-MTX is given as a monotherapy at doses of 8 mg/day (taken as 4 mg twice daily) and of 16 mg/day (taken as 8 mg twice daily).

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:26:05 GMT 2025` Edited by `admin` on `Mon Mar 31 19:26:05 GMT 2025`
Record UNII	IHU4GYZ2R3
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Hydromethylthionine

Official Name

English

10H-PHENOTHIAZINE-3,7-DIAMINE, N3,N3,N7,N7-TETRAMETHYL-

Preferred Name

English

METHYLENE BLUE, LEUCO

Common Name

English

LEUCOMETHYLENE BLUE

Common Name

English

METHYLENE BLUE LEUCO FORM

Common Name

English

hydromethylthionine [INN]

Common Name

English

N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine

Systematic Name

English

HYDROMETHYLTHIONINE [USAN]

Common Name

English

REDUCED METHYLENE BLUE

Common Name

English

LEUKOMETHYLENE BLUE

Common Name

English

Code System Code Type Description

CAS

613-11-6