HYDROMETHYLTHIONINE MESYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H19N3S.2CH4O3S
Molecular Weight	477.618
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of HYDROMETHYLTHIONINE MESYLATE

Structure Search

SMILES

CS(O)(=O)=O.CS(O)(=O)=O.CN(C)C1=CC2=C(NC3=C(S2)C=C(C=C3)N(C)C)C=C1

InChI

InChIKey=SPCMQFLNOVTUBM-UHFFFAOYSA-N

InChI=1S/C16H19N3S.2CH4O3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;2*1-5(2,3)4/h5-10,17H,1-4H3;2*1H3,(H,2,3,4)

HIDE SMILES / InChI

Molecular Formula	C16H19N3S
Molecular Weight	285.407
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	CH4O3S
Molecular Weight	96.106
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://taurx.com/lmtx-for-alzheimers.html | https://clinicaltrials.gov/ct2/show/NCT03446001 | https://www.ncbi.nlm.nih.gov/pubmed/25759392

L-MTX is a second-generation tau protein aggregation inhibitor. It acts by reducing levels of aggregated or misfolded tau proteins, which are associated with the progressive neurodegeneration. It is currently under development for the treatment of Alzheimer’s disease.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Tau protein aggregation 3 Target ID: Tau protein aggregation Sources: https://www.ncbi.nlm.nih.gov/pubmed/26809554\|http://taurx.com/lmtx-for-alzheimers.html\|https://www.ncbi.nlm.nih.gov/pubmed/25759392	Inhibitor 8297		0.12 µM [Ki]

PubMed

Title	Date	PubMed
Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease.	2015 Apr 24	25759392
Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial.	2016 Dec 10	27863809

Patents

Sample Use Guides

In Vivo Use Guide

L-MTX is given as a monotherapy at doses of 8 mg/day (taken as 4 mg twice daily) and of 16 mg/day (taken as 8 mg twice daily).

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:12:17 GMT 2023` Edited by `admin` on `Sat Dec 16 09:12:17 GMT 2023`
Record UNII	3248SEF29D
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

HYDROMETHYLTHIONINE MESYLATE

Official Name

English

TRX-0237

Code

English

LMTM

Common Name

English

LEUCOMETHYLENE BLUE BISMESYLATE

Common Name

English

LEUCO-METHYLTHIONINIUM DIMESYLATE

Common Name

English

LMTX

Code

English

LEUCOMETHYLENE BLUE DIMESYLATE

Common Name

English

TRX0237

Code

English

HYDROMETHYLTHIONINE MESYLATE [USAN]

Common Name

English

N,N,N',N'-TETRAMETHYL-10H-PHENOTHIAZINE-3,7-DIAMINIUM BIS(METHANESULFONATE)

Systematic Name

English

LEUCO-METHYLTHIONINIUM BIS(HYDROMETHANESULFONATE)

Common Name

English

10H-PHENOTHIAZINE-3,7-DIAMINE, N3,N3,N7,N7-TETRAMETHYL-, METHANESULFONATE (1:2)

Systematic Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

661118

Created by admin on Sat Dec 16 09:12:18 GMT 2023 , Edited by admin on Sat Dec 16 09:12:18 GMT 2023

Code System Code Type Description

USAN

CD-178

Created by admin on Sat Dec 16 09:12:18 GMT 2023 , Edited by admin on Sat Dec 16 09:12:18 GMT 2023

PRIMARY

PUBCHEM

60150609

Created by admin on Sat Dec 16 09:12:18 GMT 2023 , Edited by admin on Sat Dec 16 09:12:18 GMT 2023

PRIMARY

FDA UNII

3248SEF29D

Created by admin on Sat Dec 16 09:12:18 GMT 2023 , Edited by admin on Sat Dec 16 09:12:18 GMT 2023

PRIMARY

EVMPD

SUB189816

Created by admin on Sat Dec 16 09:12:18 GMT 2023 , Edited by admin on Sat Dec 16 09:12:18 GMT 2023

PRIMARY

NCI_THESAURUS

C166629

Created by admin on Sat Dec 16 09:12:18 GMT 2023 , Edited by admin on Sat Dec 16 09:12:18 GMT 2023

PRIMARY

CAS

1236208-20-0

Created by admin on Sat Dec 16 09:12:17 GMT 2023 , Edited by admin on Sat Dec 16 09:12:17 GMT 2023

PRIMARY

SMS_ID

100000175425

Created by admin on Sat Dec 16 09:12:18 GMT 2023 , Edited by admin on Sat Dec 16 09:12:18 GMT 2023

PRIMARY

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HYDROMETHYLTHIONINE

PARENT -> SALT/SOLVATE

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					IHU4GYZ2R3

HYDROMETHYLTHIONINE

ACTIVE MOIETY

Details

SMILES

InChI

DescriptionSources: http://taurx.com/lmtx-for-alzheimers.html | https://clinicaltrials.gov/ct2/show/NCT03446001 | https://www.ncbi.nlm.nih.gov/pubmed/25759392

Originator

Approval Year

Targets

PubMed

Patents

Sample Use Guides

Description
Sources: http://taurx.com/lmtx-for-alzheimers.html | https://clinicaltrials.gov/ct2/show/NCT03446001 | https://www.ncbi.nlm.nih.gov/pubmed/25759392