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Details

Stereochemistry ACHIRAL
Molecular Formula C16H19N3S
Molecular Weight 285.407
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROMETHYLTHIONINE

SMILES

CN(C)C1=CC2=C(NC3=C(S2)C=C(C=C3)N(C)C)C=C1

InChI

InChIKey=QTWZICCBKBYHDM-UHFFFAOYSA-N
InChI=1S/C16H19N3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13/h5-10,17H,1-4H3

HIDE SMILES / InChI

Description

L-MTX is a second-generation tau protein aggregation inhibitor. It acts by reducing levels of aggregated or misfolded tau proteins, which are associated with the progressive neurodegeneration. It is currently under development for the treatment of Alzheimer’s disease.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 0.12 µM [Ki]
PubMed

PubMed

TitleDatePubMed
Tau-aggregation inhibitor therapy for Alzheimer's disease.
2014 Apr 15
Patents

Patents

20030044316
3
JP2007010382A
3

Sample Use Guides

In Vivo Use Guide
L-MTX is given as a monotherapy at doses of 8 mg/day (taken as 4 mg twice daily) and of 16 mg/day (taken as 8 mg twice daily).
Route of Administration: Oral
Name Type Language
HYDROMETHYLTHIONINE
INN   USAN  
Official Name English
METHYLENE BLUE, LEUCO
Common Name English
LEUCOMETHYLENE BLUE
Common Name English
METHYLENE BLUE LEUCO FORM
Common Name English
hydromethylthionine [INN]
Common Name English
10H-PHENOTHIAZINE-3,7-DIAMINE, N3,N3,N7,N7-TETRAMETHYL-
Systematic Name English
N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine
Systematic Name English
HYDROMETHYLTHIONINE [USAN]
Common Name English
REDUCED METHYLENE BLUE
Common Name English
LEUKOMETHYLENE BLUE
Common Name English
Code System Code Type Description
CAS
613-11-6
Created by admin on Fri Dec 15 18:54:58 GMT 2023 , Edited by admin on Fri Dec 15 18:54:58 GMT 2023
PRIMARY
INN
10814
Created by admin on Fri Dec 15 18:54:58 GMT 2023 , Edited by admin on Fri Dec 15 18:54:58 GMT 2023
PRIMARY
FDA UNII
IHU4GYZ2R3
Created by admin on Fri Dec 15 18:54:58 GMT 2023 , Edited by admin on Fri Dec 15 18:54:58 GMT 2023
PRIMARY
EPA CompTox
DTXSID2047985
Created by admin on Fri Dec 15 18:54:58 GMT 2023 , Edited by admin on Fri Dec 15 18:54:58 GMT 2023
PRIMARY
CHEBI
134180
Created by admin on Fri Dec 15 18:54:58 GMT 2023 , Edited by admin on Fri Dec 15 18:54:58 GMT 2023
PRIMARY
SMS_ID
300000034135
Created by admin on Fri Dec 15 18:54:58 GMT 2023 , Edited by admin on Fri Dec 15 18:54:58 GMT 2023
PRIMARY
NCI_THESAURUS
C170046
Created by admin on Fri Dec 15 18:54:58 GMT 2023 , Edited by admin on Fri Dec 15 18:54:58 GMT 2023
PRIMARY
USAN
CD-162
Created by admin on Fri Dec 15 18:54:59 GMT 2023 , Edited by admin on Fri Dec 15 18:54:59 GMT 2023
PRIMARY
PUBCHEM
164695
Created by admin on Fri Dec 15 18:54:58 GMT 2023 , Edited by admin on Fri Dec 15 18:54:58 GMT 2023
PRIMARY
PARENT (METABOLITE)
Structure of METHYLENE BLUE CATION
NIH
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