ORPANOXIN

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H11ClO4
Molecular Weight	266.677
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(CC(O)=O)C1=CC=C(O1)C2=CC=C(Cl)C=C2

InChI

InChIKey=YLJRTDTWWRXOFG-UHFFFAOYSA-N

InChI=1S/C13H11ClO4/c14-9-3-1-8(2-4-9)11-5-6-12(18-11)10(15)7-13(16)17/h1-6,10,15H,7H2,(H,16,17)

HIDE SMILES / InChI

Molecular Formula	C13H11ClO4
Molecular Weight	266.677
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8424114 | https://www.ncbi.nlm.nih.gov/pubmed/8424114

Orpanoxin (previously known as F-776), a nonsteroidal anti-inflammatory drug that was developed as an analgesic agent. Orpanoxin is a prostaglandin synthetase inhibitor and may have a potential for the treatment of rheumatic. However, information about the current development of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Evaluation of a new anti-inflammatory/analgesic compound F-776, 5-(4-chlorophenyl)-beta-hydroxy-2-furanpropanoic acid.	1980 Feb	6966489
Inhibition of prostaglandin synthetase by F-776, 5-(4-chlorophenyl)-beta-hydroxy-2-furanpropanoic acid, a new anti-inflammatory/analgesic compound.	1981 Nov 1	6797436
Anti-inflammatory activity of orpanoxin administered orally and topically to rodents.	1985 Jul	4050616
Characterization of 5-[5-(4-chlorophenyl-2-furanyl)]dihydro-2(3H)-furanone as a nonsteroidal antiinflammatory drug.	1988 Jan	3365279

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:58:19 GMT 2023` Edited by `admin` on `Fri Dec 15 18:58:19 GMT 2023`
Record UNII	GB7E99FI6X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ORPANOXIN

Official Name

English

orpanoxin [INN]

Common Name

English

5-(P-CHLOROPHENYL)-2-FURANHYDRACRYLIC ACID

Common Name

English

F-776

Code

English

ORPANOXIN [USAN]

Common Name

English

2-FURANPROPANOIC ACID, 5-(4-CHLOROPHENYL)-.BETA.-HYDROXY-

Common Name

English

Code System Code Type Description

FDA UNII

GB7E99FI6X