CYPROLIDOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H19NO
Molecular Weight	301.3817
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC([C@@H]1C[C@H]1C2=CC=NC=C2)(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=KPUSUIKQQCFQCX-VQTJNVASSA-N

InChI=1S/C21H19NO/c23-21(17-7-3-1-4-8-17,18-9-5-2-6-10-18)20-15-19(20)16-11-13-22-14-12-16/h1-14,19-20,23H,15H2/t19-,20+/m0/s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6012765 | https://books.google.ru/books?id=nnVxhG5GLXYC&pg=PA12&lpg=PA12

Cyprolidol is a pyridylcyclopropane derivative, developed by Neisler Laboratories. In animal models, cyprolidol produced an antidepressant effect qualitatively similar to those produced by imipramine. The compound blocked the tyramine-induced rise in blood pressure only in anesthetized dogs but potentiated it in conscious dogs. In man, cyprolidol was less effective than imipramine.

Originator

Approval Year

PubMed

Title	Date	PubMed
Some pharmacological effects of a new potential antidepressant cyprolidol (IN-1060) compared with imipramine.	1966	6012765

Name

Type

Language

CYPROLIDOL

Official Name

English

cyprolidol [INN]

Common Name

English

TRANS-2-(4-PYRIDYL)-.ALPHA.,.ALPHA.-DIPHENYLCYCLOPROPANEMETHANOL

Systematic Name

English

BENZENEMETHANOL, .ALPHA.-PHENYL-.ALPHA.-(2-(4-PYRIDINYL)CYCLOPROPYL)-, TRANS-

Systematic Name

English

DIPHENYL (2-(4-PYRIDYL)CYCLOPROPYL)METHANOL

Systematic Name

English

METHANOL, DIPHENYL(2-(4-PYRIDYL)CYCLOPROPYL)-, TRANS-

Systematic Name

English

BENZENEMETHANOL, .ALPHA.-PHENYL-.ALPHA.-((1R,2R)-2-(4-PYRIDINYL)CYCLOPROPYL)-, REL-

Systematic Name

English

Code System Code Type Description

ChEMBL

CHEMBL2110906