U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C21H19NO
Molecular Weight 301.3817
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CYPROLIDOL

SMILES

OC([C@@H]1C[C@H]1C2=CC=NC=C2)(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=KPUSUIKQQCFQCX-VQTJNVASSA-N
InChI=1S/C21H19NO/c23-21(17-7-3-1-4-8-17,18-9-5-2-6-10-18)20-15-19(20)16-11-13-22-14-12-16/h1-14,19-20,23H,15H2/t19-,20+/m0/s1

HIDE SMILES / InChI

Molecular Formula C21H19NO
Molecular Weight 301.3817
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Cyprolidol is a pyridylcyclopropane derivative, developed by Neisler Laboratories. In animal models, cyprolidol produced an antidepressant effect qualitatively similar to those produced by imipramine. The compound blocked the tyramine-induced rise in blood pressure only in anesthetized dogs but potentiated it in conscious dogs. In man, cyprolidol was less effective than imipramine.

Approval Year

PubMed

PubMed

TitleDatePubMed
Some pharmacological effects of a new potential antidepressant cyprolidol (IN-1060) compared with imipramine.
1966
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:56:59 GMT 2023
Edited
by admin
on Fri Dec 15 18:56:59 GMT 2023
Record UNII
321552050N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYPROLIDOL
INN  
INN  
Official Name English
cyprolidol [INN]
Common Name English
TRANS-2-(4-PYRIDYL)-.ALPHA.,.ALPHA.-DIPHENYLCYCLOPROPANEMETHANOL
Systematic Name English
BENZENEMETHANOL, .ALPHA.-PHENYL-.ALPHA.-(2-(4-PYRIDINYL)CYCLOPROPYL)-, TRANS-
Systematic Name English
DIPHENYL (2-(4-PYRIDYL)CYCLOPROPYL)METHANOL
Systematic Name English
METHANOL, DIPHENYL(2-(4-PYRIDYL)CYCLOPROPYL)-, TRANS-
Systematic Name English
BENZENEMETHANOL, .ALPHA.-PHENYL-.ALPHA.-((1R,2R)-2-(4-PYRIDINYL)CYCLOPROPYL)-, REL-
Systematic Name English
Code System Code Type Description
ChEMBL
CHEMBL2110906
Created by admin on Fri Dec 15 18:56:59 GMT 2023 , Edited by admin on Fri Dec 15 18:56:59 GMT 2023
PRIMARY
FDA UNII
321552050N
Created by admin on Fri Dec 15 18:56:59 GMT 2023 , Edited by admin on Fri Dec 15 18:56:59 GMT 2023
PRIMARY
PUBCHEM
199758
Created by admin on Fri Dec 15 18:56:59 GMT 2023 , Edited by admin on Fri Dec 15 18:56:59 GMT 2023
PRIMARY
NCI_THESAURUS
C166627
Created by admin on Fri Dec 15 18:56:59 GMT 2023 , Edited by admin on Fri Dec 15 18:56:59 GMT 2023
PRIMARY
EPA CompTox
DTXSID801014478
Created by admin on Fri Dec 15 18:56:59 GMT 2023 , Edited by admin on Fri Dec 15 18:56:59 GMT 2023
PRIMARY
CAS
4904-00-1
Created by admin on Fri Dec 15 18:56:59 GMT 2023 , Edited by admin on Fri Dec 15 18:56:59 GMT 2023
PRIMARY
SMS_ID
100000083969
Created by admin on Fri Dec 15 18:56:59 GMT 2023 , Edited by admin on Fri Dec 15 18:56:59 GMT 2023
PRIMARY
INN
2093
Created by admin on Fri Dec 15 18:56:59 GMT 2023 , Edited by admin on Fri Dec 15 18:56:59 GMT 2023
PRIMARY
EVMPD
SUB06876MIG
Created by admin on Fri Dec 15 18:56:59 GMT 2023 , Edited by admin on Fri Dec 15 18:56:59 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY