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Restrict the search for
m nalidixic acid
to a specific field?
Status:
Investigational
Source:
INN:ascorbyl gamolenate [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Ascorbyl gamolenate, an aldehyde reductase inhibitor, participated in phase-I clinical trials for Diabetic neuropathies in the United Kingdom but these studies were discontinued.
Class (Stereo):
CHEMICAL (ACHIRAL)
Aclantate is a nonsteroidal anti-inflammatory drug.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Atrasentan (ABT-627, A-127722) is a selective endothelin A receptor antagonist. Atrasentan is being developed by AbbVie as an oral treatment for diabetic nephropathies.Abbott Laboratories was conducting clinical development of atrasentan for the treatment of certain cancers, including phase II trials for prostate cancer. However, no recent development has been reported for cancer indications and development is presumed to be discontinued.
Status:
Investigational
Class (Stereo):
CHEMICAL (RACEMIC)
Peradoxime is an antihypertensive agent. In normal animals, 37-48% of the radioactivity from an oral dose of labeled peradoxime or parenteral dose was excreted in the urine, and 48-50% in the feces. Biliary and urinary metabolites of peradoxime were principally found as conjugates with glucuronic acid.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
IPROXAMINE is a peripheral vasodilator.
Class (Stereo):
CHEMICAL (ACHIRAL)
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
S-(+)-niguldipine is a more active enantiomer and is a selective antagonist for the and α1A-adrenoceptor. In addition, it can be used for discriminating of alpha 1A- from alpha 1B-adrenoceptors. There were made attempts to investigate the antidepressant action of S-(+)-niguldipine on rats, but that studies were unsuccessful.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Elacridar is an oral bioenhancer that targets multiple drug resistance in tumors. Elacridar is a strong and relatively specific inhibitor of P-gp and BCRP, two main efflux transporters. Development of elacridar is assumed to have been discontinued.
Status:
Investigational
Class (Stereo):
CHEMICAL (ABSOLUTE)
LECOZOTAN, a benzodioxanylpiperazine derivative, is a selective serotonin 1A receptor antagonist. It was in development for the symptomatic treatment of cognitive deficits in Alzheimer's disease.
Class (Stereo):
CHEMICAL (RACEMIC)
Mercuderamide is a mercurial diuretic. It inhibits both Na+-K+-ATPase and cyclic 3',5'-AMP-dependent protein kinase.
