GPI-1485

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H19NO4
Molecular Weight	241.2836
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC(C)(C)C(=O)C(=O)N1CCC[C@H]1C(O)=O

InChI

InChIKey=FOPALECPEUVCTL-QMMMGPOBSA-N

InChI=1S/C12H19NO4/c1-4-12(2,3)9(14)10(15)13-7-5-6-8(13)11(16)17/h8H,4-7H2,1-3H3,(H,16,17)/t8-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C12H19NO4
Molecular Weight	241.2836
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.drugbank.ca/drugs/DB05 | https://www.ncbi.nlm.nih.gov/pubmed/24711047 | https://clinicaltrials.gov/ct2/show/NCT00209508 | https://clinicaltrials.gov/ct2/show/NCT00076492 | https://clinicaltrials.gov/ct2/show/NCT00090376

GPI-1485 belongs to a class of small molecule compounds called neuroimmunophilin ligands. This class of compounds has been shown to repair and regenerate damaged nerves without affecting normal, healthy nerves. GPI-1485 binds to FK-506-binding proteins. Phase 2 studies have been conducted to assess whether GPI-1485 is able to delay or stop disease progression and improve symptoms in patients with Parkinson's disease (PD), and whether GPI-1485 can help preserve erectile function after prostatectomy.

Originator

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:11:52 GMT 2025` Edited by `admin` on `Mon Mar 31 18:11:52 GMT 2025`
Record UNII	0709BVY57W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GPI-1485

Common Name

English

GPI 1485

Preferred Name

English

(2S)-1-(3,3-DIMETHYL-2-OXOPENTANOYL)-2-PYRROLIDINECARBOXYLIC ACID

Systematic Name

English

(2S)-1-(1,2-DIOXO-3,3-DIMETHYLPENTYL)-2-PYRROLIDINECARBOXYLIC ACID

Systematic Name

English

L-PROLINE, 1-(3,3-DIMETHYL-1,2-DIOXOPENTYL)-

Systematic Name

English

Code System Code Type Description

PUBCHEM

9837656