METHYLSELENOCYSTEINE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C4H9NO2Se
Molecular Weight	182.08
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[Se]C[C@H](N)C(O)=O

InChI

InChIKey=XDSSPSLGNGIIHP-VKHMYHEASA-N

InChI=1S/C4H9NO2Se/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25754033 | https://clinicaltrials.gov/ct2/show/NCT01611038

Methylselenocysteine is a part of the mammalian physiology and is a well-tolerated, versatile and economical antiangiogenic agent. This compound participated in clinical trial to determine if vitamin supplementation with this compound could restore disruption of circadian rhythm in shift workers. The preclinical efficacy of methylselenocysteine has shown the combination of methylselenocysteine with androgen deprivation therapy can be useful for the treatment of advanced prostate cancer.

Approval Year

PubMed

Title	Date	PubMed
Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression.	2004 Jul	15213307
Methylselenocysteine preventing castration-resistant progression of prostate cancer.	2015 Jun 15	25754033

Patents

Sample Use Guides

In Vivo Use Guide

Methylselenocysteine capsule given daily

Route of Administration: Oral

Name

Type

Language

METHYLSELENOCYSTEINE

Systematic Name

English

3-(METHYLSELENO)-L-ALANINE

Systematic Name

English

METHYLSELENOCYSTEINE, L-

Common Name

English

SE-METHYL-SELENO-L-CYSTEINE

Common Name

English

SE-METHYL-SELENOCYSTEINE

Common Name

English

L-ALANINE, 3-(METHYLSELENO)-

Systematic Name

English

Methylselenocysteine [WHO-DD]

Common Name

English

ALANINE, 3-(METHYLSELENYL)-, L-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C73539