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Restrict the search for
guanidine
to a specific field?
Status:
Investigational
Source:
NCT01524666: Not Applicable Human clinical trial Completed Small Fiber Neuropathy
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Status:
Investigational
Source:
NCT01444170: Phase 1/Phase 2 Interventional Completed Injury
(2006)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
INN:fluorfenidine (¹⁸F) [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Fluorfenidine F-18 is a radionucleotide used in positron emission tomography (PET) imaging procedures.
Status:
Investigational
Source:
Circ Heart Fail. Jul 2022;15(7):e009120.: Not Applicable Human clinical trial Completed Heart Failure/diagnosis
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Status:
Investigational
Source:
NCT04535193: Phase 1/Phase 2 Interventional Recruiting Cardiovascular Diseases
(2021)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT01882010: Phase 1 Interventional Completed Parkinson's Disease
(2013)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT00457574: Phase 1 Interventional Withdrawn Solid Tumors and Lymphomas
(2007)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Teglarinad (also known as GMX1777) is a prodrug of GMX1778 and is an inhibitor of nicotinamide phosphoribosyl transferase (NAMPT). It is known that NAMPT involves in NAD(+) biosynthesis, which serves as an important substrate for proteins involved in DNA repair. Teglarinad was evaluated in two human head and neck cancer models in combination with radiotherapy. It was shown that the combining GMX1777 with pemetrexed was an effective new therapeutic strategy to treat nonsquamous non-small cell lung carcinoma (NSCLC). In addition, the drug participated in clinical trial phase I/II in combination with temozolomide for the treatment of metastatic melanoma, however, this study was terminated due to financial constraints.
Status:
Investigational
Source:
NCT02669563: Early Phase 1 Interventional Completed Cardiomyopathy
(2015)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Class (Stereo):
CHEMICAL (ACHIRAL)
Guanoctine was studied as an antihypertensive agent.
Class (Stereo):
CHEMICAL (ACHIRAL)
Guancydine, an antihypertensive agent which anti-angiotensin effect was not observed.
