GUANCYDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H14N4
Molecular Weight	154.2129
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC(C)(C)NC(=N)NC#N

InChI

InChIKey=VZVGEDRCVUKSEL-UHFFFAOYSA-N

InChI=1S/C7H14N4/c1-4-7(2,3)11-6(9)10-5-8/h4H2,1-3H3,(H3,9,10,11)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/562730 | https://www.ncbi.nlm.nih.gov/pubmed/325301

Guancydine, an antihypertensive agent which anti-angiotensin effect was not observed.

Approval Year

PubMed

Title	Date	PubMed
Cardiovascular actions of guancydine in normotensive and hypertensive animals.	1968 May	4296847
[Studies on the action of the antihypertensive agent guancydine. II. Potentiation of the effect by pretreatment with furosemide or mefruside in the rat].	1971	5143296
Guancydine: a new antihypertensive agent. Use with quinethazone and guanethidine or propranolol.	1972 Apr	4565483
Guancydine, a new hypotensive agent with complex action.	1977	562730

Sample Use Guides

In Vivo Use Guide

The hypotensive effect of a single oral dose of 500-750 mg persists for about 6-7 hours after its administration. Guancydine does not impair the vasopressor response to angiotensin II but reduces the action of this peptide on the excretion of water, Na, K and Ca through urine.

Route of Administration: Oral

Name

Type

Language

GUANCYDINE

Official Name

English

guancidine [INN]

Common Name

English

CL-2422

Code

English

2-Cyano-1-tert-pentylguanidine

Systematic Name

English

GUANCIDINE

Official Name

English

GUANIDINE, N''-CYANO-N-(1,1-DIMETHYLPROPYL)-

Systematic Name

English

CL 2422

Code

English

GUANCYDINE [USAN]

Common Name

English

Code System Code Type Description

EVMPD

SUB07982MIG