Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H14N4 |
| Molecular Weight | 154.2129 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(C)(C)NC(=N)NC#N
InChI
InChIKey=VZVGEDRCVUKSEL-UHFFFAOYSA-N
InChI=1S/C7H14N4/c1-4-7(2,3)11-6(9)10-5-8/h4H2,1-3H3,(H3,9,10,11)
| Molecular Formula | C7H14N4 |
| Molecular Weight | 154.2129 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cardiovascular actions of guancydine in normotensive and hypertensive animals. | 1968 May |
|
| [Studies on the action of the antihypertensive agent guancydine. II. Potentiation of the effect by pretreatment with furosemide or mefruside in the rat]. | 1971 |
|
| Guancydine: a new antihypertensive agent. Use with quinethazone and guanethidine or propranolol. | 1972 Apr |
|
| Guancydine, a new hypotensive agent with complex action. | 1977 |
|
| Effect of guancydine on systemic and renal hemodynamics in arterial hypertension. | 1977 Jun |
Sample Use Guides
The hypotensive effect of a single oral dose of 500-750 mg persists for about 6-7 hours after its administration. Guancydine does not impair the vasopressor response to angiotensin II but reduces the action of this peptide on the excretion of water, Na, K and Ca through urine.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:10:32 GMT 2023
by
admin
on
Fri Dec 15 17:10:32 GMT 2023
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| Record UNII |
71Y9TQ5U2Z
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| Record Status |
Validated (UNII)
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| Record Version |
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C175080
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C100199
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CHEMBL1697839
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
