5'-GUANYLIC ACID

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H14N5O8P
Molecular Weight	363.2206
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NC2=C(N=CN2[C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

InChIKey=RQFCJASXJCIDSX-UUOKFMHZSA-N

InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1

HIDE SMILES / InChI

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
RNA biosynthetic process 6 Target ID: GO:0032774 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10346866 \| https://www.istockphoto.com/ru/%D0%B2%D0%B5%D0%BA%D1%82%D0%BE%D1%80%D0%BD%D0%B0%D1%8F/guanosine-monophosphate-molecule-monomer-in-rna-structural-chemical-formula-and-gm901983670-248832446	Activator 1430

PubMed

Title	Date	PubMed
The guanylyl cyclase family at Y2K.	2001	11181955
C-type natriuretic peptide concentrations in the plasma and cerebrospinal fluid of patients with subarachnoid hemorrhage.	2001	11178224
Natriuretic peptides suppress vascular endothelial cell growth factor signaling to angiogenesis.	2001 Apr	11250939
Opposing actions of nitric oxide on synaptic inputs of identified interneurones in the central nervous system of the crayfish.	2001 Apr	11249841
Modulation of nitrergic relaxant responses by peptides in the mouse gastric fundus.	2001 Apr 2	11179775
Methylene blue reduces lung fluid filtration during the early phase of endotoxemia in awake sheep.	2001 Feb	11246319
Distribution of genetic variation among chromosomal forms of Anopheles gambiae s.s: introgressive hybridization, adaptive inversions, or recent reproductive isolation?	2001 Feb	11240631
Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: effects of glycemic control.	2001 Feb	11239518
[Pharmacological profiles of mycophenolate mofetil (CellCept), a new immunosuppressive agent].	2001 Feb	11233304
NO Inhibits NaCl absorption by rat thick ascending limb through activation of cGMP-stimulated phosphodiesterase.	2001 Feb	11230320
Altered myosin light-chain phosphorylation in resting platelets from premenopausal women with diabetes.	2001 Feb	11229421
Vasoactive mediator release by fetal endothelial cells in intrauterine growth restriction and preeclampsia.	2001 Feb	11228509
Effects of short chain fatty acids on colonic Na+ absorption and enzyme activity.	2001 Feb	11223395
Natriuretic peptide receptors in the central vasculature of the toad, Bufo marinus.	2001 Feb	11223387
Soluble substances released from postischemic reperfused rat hearts reduce calcium transient and contractility by blocking the L-type calcium channel.	2001 Feb	11216995
Platelet inhibitory effect of nitric oxide in the human coronary circulation: impact of endothelial dysfunction.	2001 Feb	11216971
Differential expression and synthesis of natriuretic peptides determines natriuretic peptide receptor expression in primary cultures of human proximal tubular cells.	2001 Feb	11212968
Carbon monoxide is the heme oxygenase product with a pyretic action: evidence for a cGMP signaling pathway.	2001 Feb	11208574
Effect of E. coli heat-stable enterotoxin on colonic transport in guanylyl cyclase C receptor-deficient mice.	2001 Feb	11208543
Utilization of brewer's yeast cells for the production of food-grade yeast extract. Part 1: Effects of different enzymatic treatments on solid and protein recovery and flavor characteristics.	2001 Feb	11198178
Paracrine neuroprotective effect of nitric oxide in the developing retina.	2001 Feb	11181842
Mechanisms involved in SNP-induced relaxation and [Ca+]i reduction in piglet pulmonary and systemic arteries.	2001 Feb	11181438
Pulmonary hypertension alters soluble guanylate cyclase activity and expression in pulmonary arteries isolated from fetal lambs.	2001 Feb	11180684
Use of nucleotides in weanling rats with diarrhea induced by a lactose overload: effect on the evolution of diarrhea and weight and on the histopathology of intestine, liver and spleen.	2001 Feb	11175494
An analysis of renal nitric oxide contribution to hyperfiltration in diabetic rats.	2001 Feb	11174467
G protein-mediated inhibitory effect of a nitric oxide donor on the L-type Ca2+ current in rat ventricular myocytes.	2001 Feb 15	11179396
Immunohistochemical localization of nitric oxide synthase and soluble guanylyl cyclase in the ventral cochlear nucleus of the rat.	2001 Feb 26	11169986
Possibility of age regulation of the natriuretic peptide C-receptor in human platelets.	2001 Jan	11227736
The effects of vasopressin in isolated rat hearts.	2001 Jan	11211571
Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes.	2001 Jan	11208728
Normalisation of blood pressure in hypertensive TGR(mREN2)27 rats by amlodipine vs. enalapril: effects on cardiac hypertrophy and signal transduction pathways.	2001 Jan	11191827
alpha-atrial natriuretic peptide, cyclic guanosine monophosphate, and endothelin in plasma as markers of myocardial depression in human septic shock.	2001 Jan	11176165
Biosynthesis of constitutive nitric oxide synthase-derived nitric oxide attenuates coronary vasoconstriction and myocardial depression in a model of septic heart failure induced by Staphylococcus aureus alpha-toxin.	2001 Jan	11176149
Methylene blue as a successful treatment alternative for pharmacologically induced priapism.	2001 Jan	11173934
Roles for nitric oxide and arachidonic acid in the induction of heterosynaptic cerebellar LTD.	2001 Jan 22	11201073
Plasma from preeclamptic women stimulates decidual endothelial cell growth and prostacyclin but not nitric oxide production: close correlation of prostacyclin and thromboxane production.	2001 Jan-Feb	11223355
Effects of short- and long-term exposure to c-AMP and c-GMP on the noradrenaline transporter.	2001 Mar	11249970
Adenovirus-mediated transfer of the atrial natriuretic peptide gene in rat pulmonary vascular smooth muscle cells leads to apoptosis.	2001 Mar	11241025
Mechanisms that produce nitric oxide-mediated relaxation of cerebral arteries during atherosclerosis.	2001 Mar	11239199
Differential expression of functional guanylyl cyclases in melanocytes: absence of nitric-oxide-sensitive isoform in metastatic cells.	2001 Mar	11231315
NO/cGMP signaling modulates regulation of Na+-K+-ATPase activity by angiotensin II in rat proximal tubules.	2001 Mar	11181409
Phosphodiesterase inhibitor-mediated potentiation of adenovirus delivery to myocardium.	2001 Mar	11181024
Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases.	2001 Mar	11179059
Direct effects of selective type 5 phosphodiesterase inhibitors alone or with other vasodilators on the erectile response in cats.	2001 Mar	11176530
Neural network partitioning by NO and cGMP.	2001 Mar 1	11222651
Guanylate cyclase in Dictyostelium discoideum with the topology of mammalian adenylate cyclase.	2001 Mar 15	11237875
Crystal structure of unligated guanylate kinase from yeast reveals GMP-induced conformational changes.	2001 Mar 16	11243817
NO-independent regulatory site on soluble guanylate cyclase.	2001 Mar 8	11242081
Mechanisms involved in the blunted nitric oxide-cGMP pathway in hypertensive TGR(mREN2)27 rats.	2001 Mar 9	11245848
Nitric oxide as modulator of neuronal function.	2001 May	11250062

Patents

Name

Type

Language

5'-GUANYLIC ACID

Systematic Name

English

GUANOSINE 5'-(DIHYDROGEN PHOSPHATE)

Systematic Name

English

GMP

Common Name

English

GUANOSINE 5'-PHOSPHATE

Systematic Name

English

INS NO.626

Code

English

5'-GUANYLIC ACID [MI]

Common Name

English

GUANOSINE 5'-MONOPHOSPHORIC ACID

Common Name

English

GUANOSINE MONOPHOSPHATE

Systematic Name

English

5'-GMP

Common Name

English

E 626

Code

English

GUANYLIC ACID

Common Name

English

INS-626

Code

English

GUANOSINE 5'-PHOSPHORIC ACID

Common Name

English

GUANIDINE MONOPHOSPHATE

Systematic Name

English

GUANOSINE 5'-MONOPHOSPHATE

Systematic Name

English

E-626

Code

English

Classification Tree Code System Code

CODEX ALIMENTARIUS (GSFA)

INS-626