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Restrict the search for
pantothenic acid
to a specific field?
Status:
Investigational
Source:
NCT00143520: Phase 2/Phase 3 Interventional Completed Type 2 Diabetes
(2004)
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Rivoglitazone hydrochloride (CS-011) is a thiazolidinedione-derivative peroxisome proliferator–activated receptor (PPAR)-γ agonist. It has been developed as potential treatment in type 2 diabetes mellitus and was shown to decrease plasma glucose and triglyceride levels in a dose-dependent manner in animals. Phase II and III clinical studies have assessed the efficacy and safety of rivoglitazone hydrochloride in patients with type 2 diabetes mellitus.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Cefsumide is an antibiotic of the cephalosporin group patented by Fujisawa Pharmaceutical Co. Cefsumide binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Status:
Investigational
Source:
INN:tizoprolic acid [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Tizoprolic acid is an anti-lipolytic drug, a blood ketone lowering agent.
Status:
Investigational
Source:
INN:flutomidate [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Flutomidate was studied as a hypnotic agent. Information about the current use of this agent is not available.
Class (Stereo):
CHEMICAL (MIXED)
Rosaprostol is an antiulcer drug. This compound acts on the mucosal barrier in the stomach, preventing a drop in pH. More specifically, rosaprostol exhibits gastric antisecretory activity and cytoprotective action. Importantly, it does not have the undesired side effects (such as diarrhea and uterine stimulation) of other prostanoids. Rosaprostol was found to antagonize gastric acid output induced by NSAID administration and to prevent and treat the digestive disorders that resulted from taking NSAIDs. Furthermore, symptoms in patients with gastritis disappeared after administration of rosaprostol, and the drug was well-tolerated. Positive effects of rosaprostol were also reported in patients with duodenal ulcer. Several stereoisomers of rosaprostol have been synthesized.
Class (Stereo):
CHEMICAL (ACHIRAL)
Nixylic acid, an anilinonicotinic acid derivative, is an anti-inflammatory agent.
Class (Stereo):
CHEMICAL (ACHIRAL)
Cyheptropine is a tropine ester of dibenzo[a,d]cycloheptadiene-5-carboxylic acid, developed as an antiarrhythmic agent.
Class (Stereo):
CHEMICAL (ACHIRAL)
Xanoxic acid was developed as a bronchodilator that has never been marketed. Information about the current use of this agent is not available.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Mespirenone (ZK 94679, 15β,16β-methylene-spironolactone) is a steroid aldosterone antagonist. In addition, it is a quite specific inhibitor of adrenocortical mineralocorticoid synthesis. In rodents mespirenone effectively prevents aldosterone-induced hypertension. It exerts natriuretic efficacy. Although it reached phase II clinical trials, it was discontinued in 1989.
Class (Stereo):
CHEMICAL (ACHIRAL)
Cis-isomer of loxanast (IG-10) or 1-methyl-4-isohexylcyclohexane carboxylic acid has been reported as an inhibitor of delayed hypersensitivity reaction in animal models. It inhibited macrophage chemotaxis.
