LOXANAST

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H26O2
Molecular Weight	226.355
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)CCC[C@H]1CC[C@](C)(CC1)C(O)=O

InChI

InChIKey=HARNFRANZLWZKO-XBXGTLAGSA-N

InChI=1S/C14H26O2/c1-11(2)5-4-6-12-7-9-14(3,10-8-12)13(15)16/h11-12H,4-10H2,1-3H3,(H,15,16)/t12-,14+

HIDE SMILES / InChI

Description
Sources: https://link.springer.com/book/10.1007/978-1-4757-2085-3 | https://www.ncbi.nlm.nih.gov/pubmed/2860077 | https://www.ncbi.nlm.nih.gov/pubmed/3034812

Cis-isomer of loxanast (IG-10) or 1-methyl-4-isohexylcyclohexane carboxylic acid has been reported as an inhibitor of delayed hypersensitivity reaction in animal models. It inhibited macrophage chemotaxis.

Approval Year

PubMed

Title	Date	PubMed
Immunopharmacological studies on experimental glomerulonephritis.	1983	6618743
Inhibition of delayed hypersensitivity reactions by a new agent, cis-1-methyl-4-isohexylcyclohexane carboxylic acid (IG-10)--II. The mechanism regarding the action on lymphokines.	1987	3034812

Sample Use Guides

In Vitro Use Guide

In vitro, loxanast (0.1 -10 ug/ml) did not inhibit the generation of O2- from macrophages. The agent (0.1 -1 ug/ml) significantly inhibited the activity of MIF and this inhibition was not due to the facilitation of normal migration. For macrophage chemotaxis, loxanast (0.01 -1 ug/ml) significantly inhibited MCF-induced chemotaxis.

Name

Type

Language

LOXANAST

Official Name

English

loxanast [INN]

Common Name

English

CIS-4-ISOHEXYL-1-METHYLCYCLOHEXANECARBOXYLIC ACID

Common Name

English

LOXANAST [JAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C574