U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C20H19N3O4S
Molecular Weight 397.448
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RIVOGLITAZONE

SMILES

COC1=CC2=C(C=C1)N=C(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)N2C

InChI

InChIKey=XMSXOLDPMGMWTH-UHFFFAOYSA-N
InChI=1S/C20H19N3O4S/c1-23-16-10-14(26-2)7-8-15(16)21-18(23)11-27-13-5-3-12(4-6-13)9-17-19(24)22-20(25)28-17/h3-8,10,17H,9,11H2,1-2H3,(H,22,24,25)

HIDE SMILES / InChI
Rivoglitazone hydrochloride (CS-011) is a thiazolidinedione-derivative peroxisome proliferator–activated receptor (PPAR)-γ agonist. It has been developed as potential treatment in type 2 diabetes mellitus and was shown to decrease plasma glucose and triglyceride levels in a dose-dependent manner in animals. Phase II and III clinical studies have assessed the efficacy and safety of rivoglitazone hydrochloride in patients with type 2 diabetes mellitus.

Approval Year

PubMed

PubMed

TitleDatePubMed
Drug evaluation: rivoglitazone, a new oral therapy for the treatment of type 2 diabetes.
2007 Apr
Patents
Name Type Language
RIVOGLITAZONE
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
R-106056
Code English
DE-101
Code English
5-(4-(6-METHOXY-1-METHYL-1H-BENZIMIDAZOL-2-YLMETHOXY)BENZYL)THIAZOLIDIN-2,4-DIONE
Systematic Name English
rivoglitazone [INN]
Common Name English
Rivoglitazone [WHO-DD]
Common Name English
2,4-THIAZOLIDINEDIONE, 5-((4-((6-METHOXY-1-METHYL-1H-BENZIMIDAZOL-2-YL)METHOXY)PHENYL)METHYL)-
Systematic Name English
RIVOGLITAZONE [USAN]
Common Name English
CS-011
Common Name English
(±)-5-(P-((6-METHOXY-1-METHYL-2-BENZIMIDAZOLYL)METHOXY)BENZYL)-2,4-THIAZOLIDINEDIONE
Common Name English
R 106056
Code English
Classification Tree Code System Code
NCI_THESAURUS C98241
Created by admin on Fri Dec 15 16:12:25 GMT 2023 , Edited by admin on Fri Dec 15 16:12:25 GMT 2023
Code System Code Type Description
EVMPD
SUB129557
Created by admin on Fri Dec 15 16:12:25 GMT 2023 , Edited by admin on Fri Dec 15 16:12:25 GMT 2023
PRIMARY
WIKIPEDIA
RIVOGLITAZONE
Created by admin on Fri Dec 15 16:12:25 GMT 2023 , Edited by admin on Fri Dec 15 16:12:25 GMT 2023
PRIMARY
MESH
C521549
Created by admin on Fri Dec 15 16:12:25 GMT 2023 , Edited by admin on Fri Dec 15 16:12:25 GMT 2023
PRIMARY
CAS
185428-18-6
Created by admin on Fri Dec 15 16:12:25 GMT 2023 , Edited by admin on Fri Dec 15 16:12:25 GMT 2023
PRIMARY
NCI_THESAURUS
C72841
Created by admin on Fri Dec 15 16:12:25 GMT 2023 , Edited by admin on Fri Dec 15 16:12:25 GMT 2023
PRIMARY
DRUG BANK
DB09200
Created by admin on Fri Dec 15 16:12:25 GMT 2023 , Edited by admin on Fri Dec 15 16:12:25 GMT 2023
PRIMARY
USAN
MM-22
Created by admin on Fri Dec 15 16:12:25 GMT 2023 , Edited by admin on Fri Dec 15 16:12:25 GMT 2023
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INN
8081
Created by admin on Fri Dec 15 16:12:25 GMT 2023 , Edited by admin on Fri Dec 15 16:12:25 GMT 2023
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FDA UNII
3A3N0634Q6
Created by admin on Fri Dec 15 16:12:25 GMT 2023 , Edited by admin on Fri Dec 15 16:12:25 GMT 2023
PRIMARY
PUBCHEM
3055168
Created by admin on Fri Dec 15 16:12:25 GMT 2023 , Edited by admin on Fri Dec 15 16:12:25 GMT 2023
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ChEMBL
CHEMBL2104753
Created by admin on Fri Dec 15 16:12:25 GMT 2023 , Edited by admin on Fri Dec 15 16:12:25 GMT 2023
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EPA CompTox
DTXSID00870164
Created by admin on Fri Dec 15 16:12:25 GMT 2023 , Edited by admin on Fri Dec 15 16:12:25 GMT 2023
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SMS_ID
100000155471
Created by admin on Fri Dec 15 16:12:25 GMT 2023 , Edited by admin on Fri Dec 15 16:12:25 GMT 2023
PRIMARY