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Restrict the search for
penicillin v
to a specific field?
Status:
Investigational
Source:
INN:levomequitazine [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Levomequitazine is the L-enantiomer of mequitazine. The antihistaminergic activity mainly resides in the S-enantiomer, L-mequitazine, whereas the anticholinergic activity mainly resides in the D-enantiomer. It was shown, that L-enantiomer of mequitazine is less potent antagonist of human M3 muscarinic acetylcholine receptors than D-enantiomer. In vitro binding studies have shown that the affinity of L-mequitazine for H1 receptors is approximately ten times higher and to muscarinic receptors ten times lower, compared to d-mequitazine. Memory impairment was observed after administration of L-mequitazine 10 mg alone on delayed recall. This could be due to indirect effects of H1 receptor blockade. L-mequitazine 10 mg produced mild driving impairment, whereas L-mequitazine 2.5 and 5.0 mg show no effects on driving. Levomequitazine had been in phase III clinical trials by Pierre Fabre for the treatment of perennial allergic rhinitis and seasonal allergic rhinitis.
Status:
Investigational
Source:
INN:piridicillin [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Piridicillin is the semi-synthetic penicillin. It has exhibited broad-spectrum activity in vitro against gram-positive cocci, except penicillin G-resistant Staphylococcus aureus, and against gram-negative bacilli. Piridicillin is reported to be more active in-vitro than piperacillin, azlocillin or ticarcillin against Ps. aeruginosa. It is unstable at alkaline pH and displays marked inoculum independence.
Class (Stereo):
CHEMICAL (ABSOLUTE)
ROTAMICILLIN was developed as an antibiotic that has never been marketed.
Status:
Investigational
Source:
INN:benethamine penicillin [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Benethamine penicillin is a medium-long-acting insoluble penicillin salt. After a single injection, this salt acts and bacteriostatic level of penicillin is maintained in the blood for three to six days.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Arginine vasotocin (Argiprestocin, AVT) is the non-mammalian homologue of arginine vasopressin (AVP) and was first synthesized as an AVP analogue. It was later found in non-mammalian vertebrates and induces similar physiological effects as AVP. AVT is considered the primary antidiuretic hormone. AVT functions to regulate expression of social and reproductive behaviors.
Status:
Investigational
Source:
NCT00854659: Phase 1 Interventional Completed Healthy Volunteers
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
ABT-102 is a selective antagonist of transient receptor potential vanilloid type 1 (TRPV1), designed for the treatment of nociceptive pain. ABT-102 potently blocks multiple modes of TRPV1 receptor activation and effectively attenuates downstream consequences of receptor activity.
Status:
Investigational
Source:
INN:phenyracillin [INN]
Source URL:
Class (Stereo):
CHEMICAL (UNKNOWN)
Phenyracillin is the 2,5-diphenylpiperazine salt of benzylpenicillin. It is antibiotic from Pencillium spp. and also other fungal spp. Shows activity against gram-positive bacteria. Phenyracillin was well tolerated.
Class (Stereo):
CHEMICAL (RACEMIC)
Quincarbate is a quinoline derivative patented by N. V. Philips' Gloeilampenfabrieken as diuretic. At 12.5 mg/kg orally in rats Quincarbate increased urine excretion by 130%.
Class (Stereo):
CHEMICAL (ACHIRAL)
Bufrolin is xanthine derivative and mast cell stabilizer with antiallergic activity. In recent studies, Bufrolin was found to be high potency agonists of human GPR35.
Status:
Class (Stereo):
CHEMICAL (ACHIRAL)
N-Methyl Buzepide is diphenylpropane derivative with antisecretory activity.