PROLIGESTONE

Details

Stereochemistry	EPIMERIC
Molecular Formula	C24H34O4
Molecular Weight	386.5244
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1O[C@@]23CC[C@](O1)(C(C)=O)[C@@]2(C)CC[C@H]4[C@H]3CCC5=CC(=O)CC[C@]45C

InChI

InChIKey=MQSDUYIXZDSLSZ-QSDCUGRSSA-N

InChI=1S/C24H34O4/c1-5-20-27-23(15(2)25)12-13-24(28-20)19-7-6-16-14-17(26)8-10-21(16,3)18(19)9-11-22(23,24)4/h14,18-20H,5-13H2,1-4H3/t18-,19+,20?,21-,22+,23-,24+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C24H34O4
Molecular Weight	386.5244
Charge	0
Count

Stereochemistry	EPIMERIC
Additional Stereochemistry	No
Defined Stereocenters	6 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8229984 | https://www.ncbi.nlm.nih.gov/pubmed/8751273 | https://www.ncbi.nlm.nih.gov/pubmed/8852830

Proligestone is a pregnane derivative patented by Koninklijke Nederlandsche Gist-en Spiritusfabriek N. V. As a progestin medication for veterinary medicine. Proligestone is used to control estrus in dogs and cats and has also been used to treat hypersexuality in dogs and cats. Administration of progestins in the dog may result in overproduction of growth hormone, suppression of the hypothalamic-pituitary-adrenocortical axis, and insulin resistance.

Originator

Approval Year

PubMed

Title	Date	PubMed
Use of proligestone in the management of three German shepherd dogs with pituitary dwarfism.	2002-04	11996393
Comparison of the histological changes in the dog after treatment with the progestins medroxyprogesterone acetate and proligestone.	1995-12	8751273

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:24:09 GMT 2025` Edited by `admin` on `Mon Mar 31 18:24:09 GMT 2025`
Record UNII	55772LJ01V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

COVINAN

Preferred Name

English

PROLIGESTONE

Official Name

English

proligestone [INN]

Common Name

English

PROLIGESTONE [MI]

Common Name

English

PROLIGESTONE [MART.]

Common Name

English

DELVOSTERON

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C776