U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 151 - 160 of 1670 results

Status:
Investigational
Source:
NCT00352313: Phase 1/Phase 2 Interventional Completed Brain and Central Nervous System Tumors
(2006)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Status:
Investigational
Source:
INN:cefoxazole
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Cefoxazole is a semi-synthetic, first-generation cephalosporin with bactericidal activity against penicillin-resistant strains of S. aureus and used in the treatment of bovine mastitis.
Status:
Investigational
Source:
INN:tameticillin
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Tamethicillin is a basic ester pro-drug of methicillin (MET) which is converted in the body by non-specific esterases to MET. Tamethicillin was used as an antibacterial agent in the veterinary as a useful alternative for the treatment of mastitis in livestock, especially in mastitis due to beta-lactamase-producing Staphylococcus.
Status:
Investigational
Source:
INN:oxetacillin
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Oxetacillin was developed as an antibacterial drug that has never been marketed.
Status:
Investigational
Source:
INN:moxastine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Moxastine is a diarylmethane derivative with an antihistamine and anticholinergic activities.
Status:
Investigational
Source:
INN:fenbenicillin
Source URL:

Class (Stereo):
CHEMICAL (EPIMERIC)

Fenbenicillin (phenoxybenzylpenicillin) is an acid-stable, orally active penicillin. Fenbenicillin demonstrated antibacterial activity in patients suffering from streptococcal, pneumococcal, and penicillin-sensitive staphylococcal infections.
Status:
Investigational
Source:
INN:pirbenicillin
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Pirbenicillin is a broad-spectrum semisynthetic penicillin with activity against both gram-positive cocci and gram-negative bacilli. Pirbenicillin is less active than either carbenicillin or ticarcillin against Proteus spp. It is as active as carbenicillin against Serratia spp. and Enterobacter spp. Pirbenicillin demonstrated eight- and fourfold better minimal bactericidal concentration values towards Pseudomonas isolates than those of carbenicillin and ticarcillin, respectively. Pirbenicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. The drug is somewhat more stable in serum than carbenicillin. Pirbenicillin does not appear to inactivate gentamicin as rapidly as carbenicillin.
Status:
Investigational
Source:
INN:mecloqualone [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Mecloqualone is a quinazoline-class GABAergic and an analog of methaqualone. It acts as an agonist of the beta subtype of GABAa receptor and induces sedative, hypnotic and anxiolytic effects. Mecloqualone was marketed (mostly in france) under the names Nubrene and Casfen for the treatment of insomnia. Mecloqualone is no longer prescribed because of concerns about its potential for abuse and overdose. In the United States, it is registered as a Schedule-I non-narcotic controlled substance.
Status:
Investigational
Source:
INN:proligestone
Source URL:

Class (Stereo):
CHEMICAL (EPIMERIC)

Proligestone is a pregnane derivative patented by Koninklijke Nederlandsche Gist-en Spiritusfabriek N. V. As a progestin medication for veterinary medicine. Proligestone is used to control estrus in dogs and cats and has also been used to treat hypersexuality in dogs and cats. Administration of progestins in the dog may result in overproduction of growth hormone, suppression of the hypothalamic-pituitary-adrenocortical axis, and insulin resistance.
Status:
Investigational
Source:
INN:isopropicillin
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

ISOPROPICILLIN is semisynthetic penicillin.