MARIDOMYCIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C41H67NO16
Molecular Weight	829.9678
Optical Activity	UNSPECIFIED
Defined Stereocenters	18 / 18
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@H](OC)[C@@H](O[C@@H]3O[C@H](C)[C@@H](O[C@H]4C[C@@](C)(O)[C@@H](OC(=O)CC)[C@H](C)O4)[C@@H]([C@H]3O)N(C)C)[C@@H](CC=O)C[C@@H](C)[C@@H](O)\C=C\[C@]1([H])O2

InChI

InChIKey=FFXJTOKFQATYBI-UEANCSDJSA-N

InChI=1S/C41H67NO16/c1-11-30(45)55-29-19-32(47)51-22(4)18-28-27(54-28)14-13-26(44)21(3)17-25(15-16-43)37(38(29)50-10)58-40-35(48)34(42(8)9)36(23(5)53-40)57-33-20-41(7,49)39(24(6)52-33)56-31(46)12-2/h13-14,16,21-29,33-40,44,48-49H,11-12,15,17-20H2,1-10H3/b14-13+/t21-,22-,23-,24+,25+,26+,27+,28-,29-,33+,34-,35-,36-,37+,38+,39+,40+,41-/m1/s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4205650 | https://www.ncbi.nlm.nih.gov/pubmed/4782049

Maridomycin is a macrolide antibiotic. Sreptomyces sp. No. B-5050 was found to produce maridomycin. Maridomycin was found to be composed of six components, maridomycins I, II, III, IV, V and VI. Their structures are different from each other in acyl moieties at C3 and C4" positions. Maridomycins I, II, III, IV, V and VI showed similar antibacterial spectra against Gram-positive bacteria including acid-fast bacteria. Maridomycin has bacteriostatic activity rather than bactericidal activity. Prominent therapeutic effect was observed against certain Gram-positive bacterial infection in mice.

Originator

Approval Year

PubMed

Title	Date	PubMed
Maridomycin, a new macrolide antibiotic. I. Taxonomy and fermentation.	1973 Apr	4205650
Maridomycin, a new macrolide antibiotic. 3. In vitro and in vivo antibacterial activity.	1973 Apr	4782049
Microbial transformation of antibiotics II. Additional transformation products of maridomycin III.	1976 Aug	993121

Name

Type

Language

MARIDOMYCIN

Official Name

English

TURIMYCIN EP3

Common Name

English

10-(FORMYLMETHYL)-7,13-DIHYDROXY-8-METHOXY-3,12-DIMETHYL-5-OXO-4,17-DIOXABICYCLO(14.1.0)HEPTADEC-14-EN-9-YL-3,6-DIDEOXY-4-O-(2,6-DIDEOXY-3-C-METHYL-.ALPHA.-L-RIBO-HEXOPYRANOSYL)-3-(DIMETHYLAMINO)-.BETA.-D-GLUCOPYRANOSIDE 4'',7'-DIPROPIONATE (ESTER)

Common Name

English

MARIDOMYCIN III

Common Name

English

ANTIBIOTIC YL 704C1

Code

English

ANTIBIOTIC B 5050C

Code

English

maridomycin [INN]

Common Name

English

LEUCOMYCIN V, 12,13-EPOXY-12,13-DIHYDRO-, 3,4B-DIPROPANOATE, (12S,13S)-

Common Name

English

MARIDOMYCIN [JAN]

Common Name

English

Code System Code Type Description

INN

3650