MARIDOMYCIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C41H67NO16
Molecular Weight	829.9678
Optical Activity	UNSPECIFIED
Defined Stereocenters	18 / 18
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@H](OC)[C@@H](O[C@@H]3O[C@H](C)[C@@H](O[C@H]4C[C@@](C)(O)[C@@H](OC(=O)CC)[C@H](C)O4)[C@@H]([C@H]3O)N(C)C)[C@@H](CC=O)C[C@@H](C)[C@@H](O)\C=C\[C@]1([H])O2

InChI

InChIKey=FFXJTOKFQATYBI-UEANCSDJSA-N

InChI=1S/C41H67NO16/c1-11-30(45)55-29-19-32(47)51-22(4)18-28-27(54-28)14-13-26(44)21(3)17-25(15-16-43)37(38(29)50-10)58-40-35(48)34(42(8)9)36(23(5)53-40)57-33-20-41(7,49)39(24(6)52-33)56-31(46)12-2/h13-14,16,21-29,33-40,44,48-49H,11-12,15,17-20H2,1-10H3/b14-13+/t21-,22-,23-,24+,25+,26+,27+,28-,29-,33+,34-,35-,36-,37+,38+,39+,40+,41-/m1/s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4205650 | https://www.ncbi.nlm.nih.gov/pubmed/4782049

Maridomycin is a macrolide antibiotic. Sreptomyces sp. No. B-5050 was found to produce maridomycin. Maridomycin was found to be composed of six components, maridomycins I, II, III, IV, V and VI. Their structures are different from each other in acyl moieties at C3 and C4" positions. Maridomycins I, II, III, IV, V and VI showed similar antibacterial spectra against Gram-positive bacteria including acid-fast bacteria. Maridomycin has bacteriostatic activity rather than bactericidal activity. Prominent therapeutic effect was observed against certain Gram-positive bacterial infection in mice.

Originator

Approval Year

PubMed

Title	Date	PubMed
Maridomycin, a new macrolide antibiotic. I. Taxonomy and fermentation.	1973 Apr	4205650
Maridomycin, a new macrolide antibiotic. 3. In vitro and in vivo antibacterial activity.	1973 Apr	4782049

Name

Type

Language

MARIDOMYCIN

Official Name

English

TURIMYCIN EP3

Common Name

English

10-(FORMYLMETHYL)-7,13-DIHYDROXY-8-METHOXY-3,12-DIMETHYL-5-OXO-4,17-DIOXABICYCLO(14.1.0)HEPTADEC-14-EN-9-YL-3,6-DIDEOXY-4-O-(2,6-DIDEOXY-3-C-METHYL-.ALPHA.-L-RIBO-HEXOPYRANOSYL)-3-(DIMETHYLAMINO)-.BETA.-D-GLUCOPYRANOSIDE 4'',7'-DIPROPIONATE (ESTER)

Common Name

English

MARIDOMYCIN III

Common Name

English

ANTIBIOTIC YL 704C1

Code

English

ANTIBIOTIC B 5050C

Code

English

maridomycin [INN]

Common Name

English

LEUCOMYCIN V, 12,13-EPOXY-12,13-DIHYDRO-, 3,4B-DIPROPANOATE, (12S,13S)-

Common Name

English

MARIDOMYCIN [JAN]

Common Name

English

Code System Code Type Description

INN

3650