U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 151 - 160 of 2002 results

Status:
Investigational
Source:
INN:foscolic acid
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Status:
Investigational
Source:
NCT03059160: Phase 2 Interventional Unknown status Rett Syndrome
(2017)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Tridecanoic acid is a 13-carbon saturated fatty acid found in dairy products and also as a product of anaerobic biodegradation of n-hexadecane. It has been identified as a substrate of phospholipase A2. Saturated fatty acids with carbon chain lengths of C12 to C14 activated the alpha-, beta-, gamma-, and epsilon-subspecies of the protein kinase C, and this activation was synergistic with that by diacylglycerol. Tridecanoic acid(C13) was most effective among the saturated fatty acids examined.
Status:
Investigational
Source:
USAN:SULFANILATE ZINC [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Sodium sulfanilate is a salt of sulphanilic acid and has been used to monitor the degree of renal dysfunction in dogs.
Status:
Investigational
Source:
NCT01038440: Not Applicable Interventional Completed Sudden Cardiac Death
(2009)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
NCT01766817: Phase 2 Interventional Completed Idiopathic Pulmonary Fibrosis
(2013)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Status:
Investigational
Source:
NCT02195232: Phase 2/Phase 3 Interventional Completed Thromboembolism of Vein VTE in Colorectal Cancer
(2015)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Isoquercetin is a flavonoid, derivative of quercetin. It was isolated from various plant species including Ammothamnus Lehmanii, Caragana alaica, Cicer baldshuanicum, C. macroconthum, C. pungens, Euphorbia cyparissias, E. helioscapia, E. lathyris, E. lucida, E. purporata and others. It demonstrated radical scavenging activity, inhibitory effects on Na+/K+-ATPase and positive inotropic activity. It is protein disulfide isomerase (PDI) inhibitor. As a PDI inhibitor, this agent blocks PDI-mediated platelet activation, and fibrin generation, which prevents thrombus formation after vascular injury. Isoquercetin inhibited the replication of both influenza A and B viruses at the lowest effective concentration. Isoquercetin activates the ERK1/2-Nrf2 pathway and protects against cerebral ischemia-reperfusion injury in vivo and in vitro. It is being investigated for prevention of thromboembolism in selected cancer patients and as an anti-fatigue agent in kidney cancer patients treated with sunitinib.
Status:
Investigational
Source:
INN:iocanlidic acid (¹²³I) [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Iocanlidic Acid I-123 is a radiolabeled phenylfatty acid derivative studied as a diagnostic agent for myocardial imaging
Status:
Investigational
Source:
INN:pomaglumetad methionil [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

LY404039 [(-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid] is an agonist of orthosteric metabotropic glutamate receptor (mGluR)2/3. In addition, it acts as an agonist at dopamine D2 receptors. LY404039 demonstrated broad antipsychotic and anxiolytic efficacy across multiple animal models. LY-2140023 is a methionine amide prodrug of LY-404039 being developed by Eli Lilly & Co for the potential oral treatment of schizophrenia.
Status:
Investigational
Source:
USAN:UNDECANOATE [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Undecanoic acid (UDA) is a fatty acid with significant antimycotic activity. Undecanoic acid is a straight-chain, eleven-carbon saturated medium-chain fatty acid found in body fluids; the most fungitoxic of the C7:0 - C18:0 fatty acid series. It has a role as a human metabolite and an antifungal agent. It is a straight-chain saturated fatty acid and a medium-chain fatty acid. It is a conjugate acid of an undecanoate. It derives from a hydride of an undecane. Undecanoic acid inhibited the production of exocellular lipase and keratinase but stimulated the production of exocellular phospholipase A in T. rubrum undecanoic acid-resistant mutant (udar). At its minimum inhibitory concentration, undecanoic acid inhibits biosynthesis of phosphatidyl serine, phosphatidyl ethanolamine and polyphosphoinositol but does not inhibit the synthesis of phosphatidyl glycerol, phosphatidyl choline, phosphatidyl inositol and phosphatidic acid in Trichophyton rubrum. At higher concentration, however UDA inhibits biosynthesis of all phosphatides present in this dermatophyte. UDA also affects catabolism of these phosphatides. This inhibitory effect of UDA may be partially responsible for its toxic action on T. rubrum.
Status:
Investigational
Source:
INN:cloquinate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



8-Hydroxy-7-iodo-5-quinolinesulfonic acid (Ferron) showed fungistatic effect for Candida and for M. canis and T. mentagrophytes. Resotren is a chemical combination of chloroquine and iodohydroxyquinoline and, taken by mouth, is poorly absorbed and reaches the lower bowel in considerable concentration. Resotren is effective in both intestinal and extra-intestinal amoebiasis. Al-Ferron timed spectrophotometry assay is a basic method in the study on the formation of polynuclear hydroxyl aluminum species and their transformation laws in aqueous systems.