CHLOROGENIC ACID

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H18O9
Molecular Weight	354.3087
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@@H]1C[C@](O)(C[C@@H](OC(=O)\C=C\C2=CC(O)=C(O)C=C2)[C@@H]1O)C(O)=O

InChI

InChIKey=CWVRJTMFETXNAD-JUHZACGLSA-N

InChI=1S/C16H18O9/c17-9-3-1-8(5-10(9)18)2-4-13(20)25-12-7-16(24,15(22)23)6-11(19)14(12)21/h1-5,11-12,14,17-19,21,24H,6-7H2,(H,22,23)/b4-2+/t11-,12-,14-,16+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C16H18O9
Molecular Weight	354.3087
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: http://www.hmdb.ca/metabolites/HMDB29278 | http://phenol-explorer.eu/compounds/521 | https://www.ncbi.nlm.nih.gov/pubmed/25767323 | https://www.ncbi.nlm.nih.gov/pubmed/25214217 | https://www.ncbi.nlm.nih.gov/pubmed/22372995 | https://www.ncbi.nlm.nih.gov/pubmed/17994537https://www.drugbank.ca/drugs/DB12029 | https://www.ncbi.nlm.nih.gov/pubmed/11401245 | https://clinicaltrials.gov/ct2/show/NCT02621060 | https://www.ncbi.nlm.nih.gov/pubmed/28393840 | https://www.ncbi.nlm.nih.gov/pubmed/28393840

Chlorogenic acid is the ester of caffeic acid and (-)-quinic acid. Chlorogenic acid is a naturally occurring plant metabolite and can be found with the related compounds cryptochlorgenic acid and neochlorogenic acid in the leaves of Hibiscus sabdariffa, coffee, potato, eggplant, peaches, and prunes. Chlorogenic acid has been investigated as a dietary supplement to improve glucose intolerant hypoglycemia and non-alcoholic fatty liver disease. It has also been identified as a potential anticancer agent by reducing the expression of HIF-1a and Sphingosine Kinase-1. Chlorogenic acid was also identified as a neuraminidase blocker effective against influenza A virus (H1N1 and H3N2).

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Hypoxia-inducible factor 1-alpha 10 Target ID: Q16665 Gene ID: 3091.0 Gene Symbol: HIF1A Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28165392	Modulator 846
Sphingosine kinase 1 6 Target ID: Q9NYA1 Gene ID: 8877.0 Gene Symbol: SPHK1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28165392	Modulator 846
Neuraminidase 21 Target ID: CHEMBL2051 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28393840	Blocker 555	44.87 µM [EC50]
Neuraminidase 21 Target ID: CHEMBL1287607 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28393840	Blocker 555	62.33 µM [EC50]

Conditions

Condition	Modality	Highest Phase	Product
Hypertension 575 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24943289	Primary	Not Provided 511	Unknown Approved Use Unknown
Cancer 609 Sources: https://clinicaltrials.gov/ct2/show/NCT02245204	Primary	Phase I 438	Unknown Approved Use Unknown
Impaired glucose tolerance 2 Sources: https://clinicaltrials.gov/ct2/show/NCT02621060	Primary	Phase II 1147	Unknown Approved Use Unknown
Non-alcoholic fatty liver disease 32 Sources: https://clinicaltrials.gov/ct2/show/NCT02929901	Primary	Phase III 665	Unknown Approved Use Unknown
influenza A H1N1 virus infection 2 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28393840	Primary	Basic research	Unknown Approved Use Unknown
Influenza A H3N2 virus infection 2 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28393840	Primary	Basic research	Unknown Approved Use Unknown
Unknown 2596

C_max

Value	Dose	Co-administered	Analyte	Population
0.6637 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27114321	3.64 mg 3 times / day steady-state, oral dose: 3.64 mg route of administration: Oral experiment type: STEADY-STATE co-administered: TAUROCHOLIC ACID	TAUROCHOLIC ACID	CHLOROGENIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
0.7638 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27114321	3.64 mg single, oral dose: 3.64 mg route of administration: Oral experiment type: SINGLE co-administered: TAUROCHOLIC ACID	TAUROCHOLIC ACID	CHLOROGENIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
2376 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31541942	3 mg/kg single, intramuscular dose: 3 mg/kg route of administration: Intramuscular experiment type: SINGLE co-administered:		CHLOROGENIC ACID plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
2914 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31541942	3 mg/kg 1 times / day multiple, intramuscular dose: 3 mg/kg route of administration: Intramuscular experiment type: MULTIPLE co-administered:		CHLOROGENIC ACID plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
1.782 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27114321	3.64 mg 3 times / day steady-state, oral dose: 3.64 mg route of administration: Oral experiment type: STEADY-STATE co-administered: TAUROCHOLIC ACID	TAUROCHOLIC ACID	CHLOROGENIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
1.135 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27114321	3.64 mg single, oral dose: 3.64 mg route of administration: Oral experiment type: SINGLE co-administered: TAUROCHOLIC ACID	TAUROCHOLIC ACID	CHLOROGENIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
6124 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31541942	3 mg/kg single, intramuscular dose: 3 mg/kg route of administration: Intramuscular experiment type: SINGLE co-administered:		CHLOROGENIC ACID plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
7199 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31541942	3 mg/kg 1 times / day multiple, intramuscular dose: 3 mg/kg route of administration: Intramuscular experiment type: MULTIPLE co-administered:		CHLOROGENIC ACID plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
1.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27114321	3.64 mg 3 times / day steady-state, oral dose: 3.64 mg route of administration: Oral experiment type: STEADY-STATE co-administered: TAUROCHOLIC ACID	TAUROCHOLIC ACID	CHLOROGENIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
1.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/27114321	3.64 mg single, oral dose: 3.64 mg route of administration: Oral experiment type: SINGLE co-administered: TAUROCHOLIC ACID	TAUROCHOLIC ACID	CHLOROGENIC ACID plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31541942	3 mg/kg single, intramuscular dose: 3 mg/kg route of administration: Intramuscular experiment type: SINGLE co-administered:		CHLOROGENIC ACID plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31541942	3 mg/kg 1 times / day multiple, intramuscular dose: 3 mg/kg route of administration: Intramuscular experiment type: MULTIPLE co-administered:		CHLOROGENIC ACID plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inducer 1087 substrate 1946 inhibitor 2252	substrate 1193 inhibitor 2438	substrate 1388 inhibitor 2507	inhibitor 2217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
P-gp 1741 OAT3 747 CYP2E1 1060 CYP2C19 2057 OAT1 725 CYP1A2 2153 OATP1B3 961 OATP1B1 1079	COMT 8 CYP1A2 1197 SULT1A1 37 CYP2C19 1119 UGT1A6 343 CYP2E1 729 P-gp 2052 GST 5 UGT1A9 423	P-gp 301

Drug as perpetrator

Target	Modality	Activity
CYP2E1 1146	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/26160718/	likely
CYP1A2 2333	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/10871299/	no [IC50 >100 uM]
CYP2C9 2497	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/10871299/	no [IC50 >100 uM]
CYP2D6 2546	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/10871299/	no [IC50 >100 uM]
CYP3A4 2633	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/10871299/	no [IC50 >100 uM]
P-gp 1932	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/377#sid=10321213	no [Inhibition 50 uM]
CYP2C19 2141	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/10871299/	no
OAT1 730	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/21697612/	no
P-gp 1932	inducer 1966 Sources: https://pubmed.ncbi.nlm.nih.gov/20580705/	no
OAT3 749	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/21697612/	weak [Inhibition 100 uM]
CYP3A4 2633	inducer 1966 Sources: https://pubmed.ncbi.nlm.nih.gov/20580705/	weak
OATP1B1 1095	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/23571415/	yes [Inhibition 10 uM]
OATP1B3 970	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/23571415/	yes [Inhibition 10 uM]

Drug as victim

Target	Modality	Activity
CYP2C9 1193	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/22551521/	likely
CYP2E1 729	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/22551521/	major
CYP3A4 1946	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/22551521/	major
CYP1A2 1197	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/22551521/	minor
CYP2C19 1119	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/22551521/	minor
CYP2D6 1388	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/22551521/	minor
UGT1A6 343	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/10836148/	no
UGT1A9 423	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/10836148/	no
COMT 8	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/22551521/	yes
GST 5	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/22551521/	yes
P-gp 2052	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/32484174/	yes
SULT1A1 37	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/12920175/	yes

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2263	inhibitor 2237 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/720553#sid=56463713 \| https://pubchem.ncbi.nlm.nih.gov/bioassay/720551#sid=56463713

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY427037	https://www.001chemical.com/chem/search?q=DY427037
1PlusChem LLC	1P003PAI	https://www.1pchem.com/search?query=1P003PAI
1PlusChem LLC	1P00I6OP	https://www.1pchem.com/search?query=1P00I6OP
A2B Chem	AI47673	http://a2bchem.com/prod/AI47673
AA Blocks	AA00I659	http://aablocks.com/goods/Goods/detail?id=AA00I659
AK Scientific	E748	https://aksci.com/item_detail.php?cat=E748
AK Scientific	J10338	https://aksci.com/item_detail.php?cat=J10338
AK Scientific	O675	https://aksci.com/item_detail.php?cat=O675
Alfa Chemistry	ACM327979	http://www.alfa-chemistry.com/search.aspx?q=ACM327979
Alinda	ALBB-030169	http://alinda.ru/finechem_en_.html?i=ALBB-030169
Ambeed	A163338	http://www.ambeed.com/search/Search.html?keyword=A163338
Angene	AGN-PC-0R86P1	http://www.angenechemical.com/productshow/AGN-PC-0R86P1.html
ApexBio Technology	N1769	https://www.apexbt.com/catalogsearch/result/?q=N1769
ApexBio Technology	N1857	https://www.apexbt.com/catalogsearch/result/?q=N1857
Apollo Scientific	BIB6027	http://www.apolloscientific.co.uk/chemical_results.php?qstext=BIB6027&product_group=%25&search_fieldname=header_search
Apollo Scientific	OR1166	http://www.apolloscientific.co.uk/chemical_results.php?qstext=OR1166&product_group=%25&search_fieldname=header_search
AstaTech	F16266	http://astatechinc.com/CPSResult.php?CRNO=F16266
Biopurify Phytochemicals	BP0345	https://www.phytopurify.com/search.do?a=s&searchtype=3&psize=10&q=BP0345&searchhtmp=simplesearch&t=1
BOC Sciences	327-97-9	http://www.bocsci.com/description.asp?cas=327-97-9
BOC Sciences	6001-76-9	http://www.bocsci.com/description.asp?cas=6001-76-9
Capot Chemical	13036	https://www.capotchem.com/search.do?q=13036
Cayman Chemical	70930	http://www.caymanchem.com/app/template/Product.vm/catalog/70930
Chem-Impex International	21877	http://www.chemimpex.com/category/search/21877/2?filter=&search=21877&type=q&keywordoption=ANY&cid=2&fltrdesc=
Chem Scene	CS-3766	http://www.chemscene.com/goproductList/searchProductList?productObj=CS-3766
Chem4Pharma	C4PN2	https://www.chem4pharma.com/product-page/C4PN2
ChemDiv	BB58-3170	http://chemistryondemand.com:8080/eShop/search_results.jsp?idnumber=BB58-3170
ChemShuttle	151614	https://www.chemshuttle.com/catalogsearch/result/?q=151614
Combi-Blocks	QA-8481	http://www.combi-blocks.com/cgi-bin/find.cgi?QA-8481
Combi-Blocks	QC-9619	http://www.combi-blocks.com/cgi-bin/find.cgi?QC-9619
eMolecules	29541115	https://orderbb.emolecules.com/search/#?query=29541115
eMolecules	44842269	https://orderbb.emolecules.com/search/#?query=44842269
eMolecules	492483	https://orderbb.emolecules.com/search/#?query=492483
eMolecules	49777957	https://orderbb.emolecules.com/search/#?query=49777957
eMolecules	50523144	https://orderbb.emolecules.com/search/#?query=50523144
eNovation Chemicals	D401658	https://www.enovationchem.com/Products.asp?SEARCHTEXT=D401658&searchbtn.x=0&searchbtn.y=0
Frontier Scientific Services	501003455	http://orders.frontierssi.com/fssionline32/public/product.aspx?cat=501003455&type=hts
Hairui	HR123597	http://www.hairuichem.com/en/product/search.do?q=HR123597
Indofine	024991S	https://indofinechemical.com/details.aspx?Sku=024991S
Indofine	06-040	https://indofinechemical.com/details.aspx?Sku=06-040
Indofine	C-002	https://indofinechemical.com/details.aspx?Sku=C-002
KeyOrganics	AS-12284	http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=AS-12284
KeyOrganics	VS-08670	http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=VS-08670
Lab Network	LN01830864	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01830864
Lab Seeker	SC-13943	http://www.labseeker.com/search.php?keywords=SC-13943&category=0
LabSeeker	SC-13943	http://www.labseeker.com/search.php?keywords=SC-13943&category=0
Matrix Scientific	90566	http://www.matrixscientific.com/090566.html
mcule	MCULE-5282788280	https://mcule.com/MCULE-5282788280/
mcule	MCULE-8135887819	https://mcule.com/MCULE-8135887819/
mcule	MCULE-8331698684	https://mcule.com/MCULE-8331698684/
MedChem Express	HY-N0055	https://www.medchemexpress.com/search.html?q=HY-N0055&ft=&fa=&fp=
Molcore	MC427037	http://www.molcore.com/CatMC427037.html
Molnova	M19253	https://www.molnova.com/en/serch-list.html?keywords=M19253
MolPort	MolPort-001-740-212	https://www.molport.com/shop/molecule-link/MolPort-001-740-212
MolPort	MolPort-001-759-169	https://www.molport.com/shop/molecule-link/MolPort-001-759-169
MolPort	MolPort-004-955-158	https://www.molport.com/shop/molecule-link/MolPort-004-955-158
MolPort	MolPort-020-392-495	https://www.molport.com/shop/molecule-link/MolPort-020-392-495
MuseChem	I003163	https://www.musechem.com/product/I003163.html
Oakwood	213614	http://www.oakwoodchemical.com/ProductsList.aspx?txtSearch=213614
Princeton BioMolecular Research	OSSL_298285	http://www.princetonbio.com/order_online?common_id=OSSL_298285
Ryan Scientific	Nicotine	https://ryansci.com/products?q=Nicotine&list_q=&search_type=exact
Selleck Chemicals	S2280	http://www.selleckchem.com/search.html?searchDTO.searchParam=S2280
Specs	AP-163/40806917	http://www.specs.net/enter.php?specsid=AP-163/40806917
SynQuest	375840	http://www.synquestlabs.com/search-result.html?q=2929-1-04
TargetMol	BBP03169	https://www.targetmol.com/search?keyword=BBP03169
TargetMol	T2805	https://www.targetmol.com/search?keyword=T2805
TargetMol	T6S1538	https://www.targetmol.com/search?keyword=T6S1538
Tetrahedron	TS32681	http://www.thsci.com/search.do?q=TS32681
TimTec	ST056308	http://www.echemstore.com/catalogsearch/result/?q=ST056308
Toronto Research Chemicals	C366540	https://www.trc-canada.com/product-detail/?CatNum=C366540
Vitas-M Laboratory	BBL028113	http://www.vitasmlab.biz/search/BBL028113
Vitas-M Laboratory	STL377917	http://www.vitasmlab.biz/search/STL377917
W&J PharmaChem	50A211812	http://wjpharmachem.com/new/searcht.php?keyword=50A211812

PubMed

Title	Date	PubMed
Acetaminophen hepatotoxicity and sterile inflammation: The mechanism of protection of Chlorogenic acid.	2016-01-05	26363200
The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation.	2015-08-05	26079055
Renoprotective mechanisms of chlorogenic acid in cisplatin-induced kidney injury.	2014-10-03	25043994
Separation and Identification of Phenolic Acid and Flavonoids from Nerium indicum Flowers.	2014-02-05	25767323
Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.	2013-01-07	23146752
Inhibitory effects of caffeic acid phenethyl ester derivatives on replication of hepatitis C virus.	2013	24358168
Looking for the physiological role of anthocyanins in the leaves of Coffea arabica.	2012-03-01	22372995
Interaction of cinnamic acid derivatives with commercial hypoglycemic drugs on 2-deoxyglucose uptake in 3T3-L1 adipocytes.	2011-09-28	21870829
Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice.	2010-12-15	20854806
Antihyperlipidemic effect of chlorogenic acid and tetrahydrocurcumin in rats subjected to diabetogenic agents.	2010-12-05	20696151
Biochemical mechanism of caffeic acid phenylethyl ester (CAPE) selective toxicity towards melanoma cell lines.	2010-10-06	20685355
Naturally occurring phenolic acids inhibit 12-O-tetradecanoylphorbol-13-acetate induced NF-kappaB, iNOS and COX-2 activation in mouse epidermis.	2010-01-31	20026373
Examining the genomic influence of skin antioxidants in vitro.	2010	20706672
Profiling the phenolic compounds of Artemisia pectinata by HPLC-PAD-MSn.	2007-11-13	17994537
Novel screening assay for antioxidant protection against peroxyl radical-induced loss of protein function.	2007-11	17705259
Analysis of interaction property of bioactive components in Danggui Buxue Decoction with protein by microdialysis coupled with HPLC-DAD-MS.	2007-06-01	17383242
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006-11	16497524
Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats.	2006-07	16869989
Chlorogenic acid is absorbed in its intact form in the stomach of rats.	2006-05	16614403
Activation of rat liver microsomal glutathione S-transferase by gallic acid.	2005-11-19	16125204
Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid.	2005-07-29	15944151
Interactions of human serum albumin with chlorogenic acid and ferulic acid.	2004-09-24	15374625
Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation.	2004-07-02	15117964
Apple phytochemicals and their health benefits.	2004-05-12	15140261
Effects of coffee components on the response of GABA(A) receptors expressed in Xenopus oocytes.	2003-12-17	14664509
Effect of antioxidants, oxidants, metals and saliva on cytotoxicity induction by sodium fluoride.	2003-12-12	14666669
Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats.	2003-06	12771329
Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans.	2003-06	12771321
Identification of isomeric dicaffeoylquinic acids from Eleutherococcus senticosus using HPLC-ESI/TOF/MS and 1H-NMR methods.	2002-12-24	12494749
Glucose 6-phosphate transport in fibroblast microsomes from glycogen storage disease type 1b patients: evidence for multiple glucose 6-phosphate transport systems.	2001-07-15	11439108
LC/ES-MS detection of hydroxycinnamates in human plasma and urine.	2001-04	11308321
Steroid hormone activity of flavonoids and related compounds.	2000-07	10989984
Action of chlorogenic acid on the complement system.	1999	10412494
Dietary effects on the uptake of benzo[a]pyrene.	1994-08	8070737

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:24:08 GMT 2025` Edited by `admin` on `Mon Mar 31 20:24:08 GMT 2025`
Record UNII	318ADP12RI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHLOROGENIC ACID

Common Name

English

CP CHLOROGENIC ACID

Preferred Name

English

5-O-(3,4-DIHYDROXYCINNAMOYL)-L-QUINIC ACID

Common Name

English

CYCLOHEXANECARBOXYLIC ACID, 3-(((2E)-3-(3,4-DIHYDROXYPHENYL)-1-OXO-2-PROPEN-1-YL)OXY)-1,4,5-TRIHYDROXY-, (1S,3R,4R,5R)-

Systematic Name

English

HERIGUARD

Brand Name

English

Chlorogenic acid [WHO-DD]

Common Name

English

TRANS-CAFFEIC ACID 5-O-D-QUINATE

Common Name

English

CYCLOHEXANECARBOXYLIC ACID, 3-((3-(3,4-DIHYDROXYPHENYL)-1-OXO-2-PROPENYL)OXY)-1,4,5-TRIHYDROXY-, (1S-(1-.ALPHA.,3-.BETA.,4-.ALPHA.,5-.ALPHA.))-

Common Name

English

(+)-CHLOROGENIC ACID

Common Name

English

5-CQA

Common Name

English

TRANS-5-O-CAFFEOYLQUINIC ACID

Common Name

English

NSC-407296

Code

English

NSC-70861

Code

English

CHLOROGENIC ACID (CONSTITUENT OF ST. JOHN'S WORT) [DSC]

Common Name

English

CYCLOHEXANECARBOXYLIC ACID, 3-((3-(3,4-DIHYDROXYPHENYL)-1-OXO-2-PROPENYL)OXY)-1,4,5-TRIHYDROXY-, (1S,3R,4R,5R)-

Common Name

English

CHLOROGENIC ACID [USP-RS]

Common Name

English

CHLOROGENIC ACID [MI]

Common Name

English

CHLOROGENIC ACID (CONSTITUENT OF ECHINACEA ANGUSTIFOLIA ROOT, ECHINACEA PALLIDA ROOT, ECHINACEA PURPUREA ROOT AND ECHINACEA PURPUREA AERIAL PARTS) [DSC]

Common Name

English

TRANS-CHLOROGENIC ACID

Common Name

English

Classification Tree Code System Code

DSLD

354 (Number of products:22)