INOSINIC ACID

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H13N4O8P
Molecular Weight	348.206
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)N2C=NC3=C2N=CNC3=O

InChI

InChIKey=GRSZFWQUAKGDAV-KQYNXXCUSA-N

InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Acid phosphatase/phosphotransferases from enteric bacteria.	2001	16233057
Carbohydrate handling enzymes in fetal Down syndrome brain.	2001	11771744
The novel IMPDH inhibitor VX-497 prolongs skin graft survival and improves graft versus host disease in mice.	2001	11447770
Analysis of the serologic response to systemic Candida albicans infection in a murine model.	2001 Apr	11681208
Anti-inflammatory effects of inosine in human monocytes, neutrophils and epithelial cells in vitro.	2001 Dec	11712075
Allantoin formation and urate and glutathione exchange in human muscle during submaximal exercise.	2001 Dec 1	11728802
Mismatched double-stranded RNA. Ampligen, Oragen, polyI:polyC12U.	2002	12001818
Catabolism of cytoplasmic and intramitochondrial adenine nucleotides in C2C12 skeletal myotube under chemical hypoxia.	2002 Apr	12014580
Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors.	2002 Dec 10	12451183
Overview of screening for new microbial catalysts and their uses in organic synthesis--selection and optimization of biocatalysts.	2002 Mar 14	11792452
[Purine regulon of gamma-proteobacteria: a detailed description].	2002 Sep	12391881
Depletion of intracellular GTP results in nuclear factor-kappaB activation and intercellular adhesion molecule-1 expression in human endothelial cells.	2002 Sep	12181421
Aptamer-based biosensor arrays for detection and quantification of biological macromolecules.	2003 Aug 15	12871718
Phosphorylation and dephosphorylation of polyhydroxy compounds by class A bacterial acid phosphatases.	2003 Aug 21	12968332
Comparison of Al-induced gene expression in sensitive and tolerant soybean cultivars.	2003 Dec	14623943
Intrinsic acid-base properties of purine derivatives in aqueous solution and comparison of the acidifying effects of platinum(II) coordinated to N1 or N7: acidifying effects are reciprocal and the proton "outruns" divalent metal ions.	2003 Jan 13	12513075
Inhibition of caffeine biosynthesis in tea (Camellia sinensis) and coffee (Coffea arabica) plants by ribavirin.	2003 Nov 20	14623114
Pickles, pectin, and penicillin.	2004	15487928
Effect of interferon-alpha and interferon-inducers on West Nile virus in mouse and hamster animal models.	2004 Mar	15185728
An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients.	2004 Nov	15621150
Mechanisms of action of mycophenolate mofetil.	2005	15803924
Polyinosinic acid induces TNF and NO production as well as NF-kappaB and AP-1 transcriptional activation in the monocytemacrophage cell line RAW 264.7.	2005 Aug	16158333
Stoichiometric estimates of the biochemical conversion efficiencies in tsetse metabolism.	2005 Aug 5	16083496
Creatine supplementation reduces muscle inosine monophosphate during endurance exercise in humans.	2005 Dec	16331129
Study of the reactions between platinum(II) complexes and L-methionine in the presence and absence of 5'-GMP.	2005 Jul	15927265
Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus.	2005 Jun	15911031
Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition.	2005 May 9	15882454
Competitive reactions of L-methionine and 5'-GMP towards platinum (II) complexes.	2005 Nov	16787339
[Genetic parameter estimation for inosine-5-monophosphate and intramuscular fat contents and other meat quality traits in chicken muscle].	2005 Nov	16378936
Mechanisms of action of mycophenolate mofetil in preventing acute and chronic allograft rejection.	2005 Oct 15	16251851
Indications of mycophenolate mofetil in liver transplantation.	2005 Sep 27	16286893
Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice.	2006	17176632
Structure of SAICAR synthase from Thermotoga maritima at 2.2 angstroms reveals an unusual covalent dimer.	2006 Apr 1	16582479
TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules.	2007 Apr 15	17404303
Sources of umami taste in Cheddar and Swiss cheeses.	2007 Aug	17995691
Correlation between breakdown of the blood-brain barrier and disease outcome of viral encephalitis in mice.	2007 Aug	17223204
Characterization of retinal inosine monophosphate dehydrogenase 1 in several mammalian species.	2007 Oct 3	17960124
The plasma ammonia response to cycle exercise in COPD.	2008 Apr	18094007
Multiple receptor systems for glutamate detection in the taste organ.	2008 Oct	18827337
Identification and characterization of two trypanosome TFIIS proteins exhibiting particular domain architectures and differential nuclear localizations.	2008 Sep	18627464

Patents

Name

Type

Language

INOSINIC ACID

Common Name

English

CYTOSINE INOSINATE

Preferred Name

English

INOSINIC ACID [MI]

Common Name

English

INOSINIC ACID, 5'-

Common Name

English

IMP

Common Name

English

HYPOXANTHINE RIBOSIDE-5-PHOSPHORIC ACID

Common Name

English

Cytosine inosinate [WHO-DD]

Common Name

English

INOSINE 5'-(DIHYDROGEN PHOSPHATE)

Systematic Name

English

E-630

Code

English

INOSINE PHOSPHATE

Common Name

English

5'-IMP

Common Name

English

INS NO.630

Code

English

INS-630

Code

English

INOSINE-5'-MONOPHOSPHORIC ACID

Common Name

English

5'-INOSINIC ACID

Systematic Name

English

Classification Tree Code System Code

CODEX ALIMENTARIUS (GSFA)

INS-630