INOSINIC ACID

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H13N4O8P
Molecular Weight	348.206
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)N2C=NC3=C2N=CNC3=O

InChI

InChIKey=GRSZFWQUAKGDAV-KQYNXXCUSA-N

InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Acid phosphatase/phosphotransferases from enteric bacteria.	2001	16233057
Ageing and immunosuppression in kidney transplantation.	2004 Dec	15859933
Interferon: ten stories in one. A short review of some of the highlights in the history of an almost quinquagenarian.	2005	16400870
Mechanisms of action of mycophenolate mofetil.	2005	15803924
Polyinosinic acid induces TNF and NO production as well as NF-kappaB and AP-1 transcriptional activation in the monocytemacrophage cell line RAW 264.7.	2005 Aug	16158333
Stoichiometric estimates of the biochemical conversion efficiencies in tsetse metabolism.	2005 Aug 5	16083496
Creatine supplementation reduces muscle inosine monophosphate during endurance exercise in humans.	2005 Dec	16331129
Study of the reactions between platinum(II) complexes and L-methionine in the presence and absence of 5'-GMP.	2005 Jul	15927265
Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus.	2005 Jun	15911031
Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes.	2005 Mar 18	15774020
Guanylic nucleotide starvation affects Saccharomyces cerevisiae mother-daughter separation and may be a signal for entry into quiescence.	2005 May 4	15869715
Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition.	2005 May 9	15882454
Competitive reactions of L-methionine and 5'-GMP towards platinum (II) complexes.	2005 Nov	16787339
[Genetic parameter estimation for inosine-5-monophosphate and intramuscular fat contents and other meat quality traits in chicken muscle].	2005 Nov	16378936
Mechanisms of action of mycophenolate mofetil in preventing acute and chronic allograft rejection.	2005 Oct 15	16251851
Indications of mycophenolate mofetil in liver transplantation.	2005 Sep 27	16286893
Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice.	2006	17176632
Structure of SAICAR synthase from Thermotoga maritima at 2.2 angstroms reveals an unusual covalent dimer.	2006 Apr 1	16582479
The nucleotide derivatives inosine and inosinic acid inhibit intestinal absorption of mizoribine in rats.	2006 Feb 15	16438959
Detection of eight antibodies in cancer patients' sera against proteins derived from the adenocarcinoma A549 cell line using proteomics-based analysis.	2006 Jun 21	16707281
Why do mutations in the ubiquitously expressed housekeeping gene IMPDH1 cause retina-specific photoreceptor degeneration?	2006 Sep	16936083
Effect of exogenous interferon and an interferon inducer on western equine encephalitis virus disease in a hamster model.	2007 Apr 10	17118420
TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules.	2007 Apr 15	17404303
Sources of umami taste in Cheddar and Swiss cheeses.	2007 Aug	17995691
Correlation between breakdown of the blood-brain barrier and disease outcome of viral encephalitis in mice.	2007 Aug	17223204
Formamide as the main building block in the origin of nucleic acids.	2007 Aug 16	17767725
Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor.	2007 Feb 1	17005341
Oxidation of chylomicron remnant-like particles inhibits their uptake by THP-1 macrophages by apolipoprotein E-dependent processes.	2007 Jul	17540618
Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).	2007 Jul 26	17585753
Pathway aberrations of murine melanoma cells observed in Paired-End diTag transcriptomes.	2007 Jun 26	17594473
Cross-protection against H5N1 influenza virus infection is afforded by intranasal inoculation with seasonal trivalent inactivated influenza vaccine.	2007 Nov 1	17922395
IMPDH1 promoter mutations in a patient exhibiting azathioprine resistance.	2007 Oct	17001353
A motif-based search in bacterial genomes identifies the ortholog of the small RNA Yfr1 in all lineages of cyanobacteria.	2007 Oct 17	17941988
Characterization of retinal inosine monophosphate dehydrogenase 1 in several mammalian species.	2007 Oct 3	17960124
Intranasal immunization with H5N1 vaccine plus Poly I:Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge.	2007 Sep	17890128
The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation.	2008	18644147
The plasma ammonia response to cycle exercise in COPD.	2008 Apr	18094007
Kinetic studies on the reactions of [Pd(dach)(X-Y)] complexes with some DNA constituents.	2008 Feb 14	18239837
Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis.	2008 Jan	18215774
IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations.	2008 Jan	17662091
Effects of dietary inosinic acid on carcass characteristics, meat quality, and deposition of inosinic acid in broilers.	2008 Jul	18577617
Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes.	2008 Jul	18557814
Estimation of genetic parameters for contents of intramuscular fat and inosine-5'-monophosphate and carcass traits in Chinese Beijing-You chickens.	2008 Jun	18492997
C3H/HeN mouse model for the evaluation of antiviral agents for the treatment of Venezuelan equine encephalitis virus infection.	2008 Jun	18313150
Expression of caffeine biosynthesis genes in tea (Camellia sinensis).	2008 Mar-Apr	18533472
Multiple receptor systems for glutamate detection in the taste organ.	2008 Oct	18827337
Identification and characterization of two trypanosome TFIIS proteins exhibiting particular domain architectures and differential nuclear localizations.	2008 Sep	18627464
Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3.	2008 Sep	18550257
Predicting the sensitivity and specificity of published real-time PCR assays.	2008 Sep 25	18817537
A clinical grade poly I:C-analogue (Ampligen) promotes optimal DC maturation and Th1-type T cell responses of healthy donors and cancer patients in vitro.	2009 Jan 1	18977262

Patents

Name

Type

Language

INOSINIC ACID

Common Name

English

INOSINIC ACID [MI]

Common Name

English

INOSINIC ACID, 5'-

Common Name

English

IMP

Common Name

English

HYPOXANTHINE RIBOSIDE-5-PHOSPHORIC ACID

Common Name

English

Cytosine inosinate [WHO-DD]

Common Name

English

INOSINE 5'-(DIHYDROGEN PHOSPHATE)

Systematic Name

English

E-630

Code

English

INOSINE PHOSPHATE

Common Name

English

5'-IMP

Common Name

English

INS NO.630

Code

English

INS-630

Code

English

INOSINE-5'-MONOPHOSPHORIC ACID

Common Name

English

5'-INOSINIC ACID

Systematic Name

English

CYTOSINE INOSINATE

Common Name

English

Classification Tree Code System Code

CODEX ALIMENTARIUS (GSFA)

INS-630