FLORILGLUTAMIC ACID F-18

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C8H14FNO4
Molecular Weight	206.202
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@@H](C[C@H](CCC[18F])C(O)=O)C(O)=O

InChI

InChIKey=MKDNDKMECWBLOF-XUCPOOORSA-N

InChI=1S/C8H14FNO4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-4,10H2,(H,11,12)(H,13,14)/t5-,6-/m0/s1/i9-1

HIDE SMILES / InChI

Molecular Formula	C8H14FNO4
Molecular Weight	206.202
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21750203 | https://ec.europa.eu/health/documents/community-register/html/o1632.htm | https://clinicaltrials.gov/ct2/show/NCT03824535

FLORILGLUTAMIC ACID F-18 is a radioactive L-glutamate derivative and a tumor-specific positron emission tomography (PET) tracer. Orphan designation (EU/3/16/1632) was granted by the European Commission to Piramal Imaging GmbH, Germany, for FLORILGLUTAMIC ACID F-18 for the diagnosis of hepatocellular carcinoma. Currently, it is in phase II trial as a PET tracer in early lung cancer in patients with lung nodules.

Originator

Approval Year

PubMed

Title	Date	PubMed
Specific PET imaging of xC- transporter activity using a ¹⁸F-labeled glutamate derivative reveals a dominant pathway in tumor metabolism.	2011 Sep 15	21750203
Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC- transporter using positron emission tomography in patients with non-small cell lung or breast cancer.	2012 Oct 1	22893629
(4S)-4-(3-18F-fluoropropyl)-L-glutamate for imaging of xC transporter activity in hepatocellular carcinoma using PET: preclinical and exploratory clinical studies.	2013 Jan	23232273

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:40:45 GMT 2023` Edited by `admin` on `Sat Dec 16 01:40:45 GMT 2023`
Record UNII	92T1Y5X038
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLORILGLUTAMIC ACID F-18

Common Name

English

florilglutamic acid (¹⁸F) [INN]

Common Name

English

FLORILGLUTAMIC ACID (18F)

Official Name

English

(2S,4S)-2-AMINO-4-(3-(18F)-FLUOROPROPYL)PENTANEDIOIC ACID

Systematic Name

English

(F18) FLORILGLUTAMIC ACID

Common Name

English

BAY-949392

Code

English

FLORILGLUTAMIC ACID ((SUP 18)F)

Common Name

English

BAY-94-9392

Code

English

FSPG F-18

Common Name

English

BAY 94-9392

Code

English

FLORILGLUTAMIC ACID (18-F)

Common Name

English

18F-FSPG

Common Name

English

L-GLUTAMIC ACID, 4-(3-(FLUORO-18F)PROPYL)-, (4S)-

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

538716