INOSINIC ACID

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H13N4O8P
Molecular Weight	348.206
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)N2C=NC3=C2N=CNC3=O

InChI

InChIKey=GRSZFWQUAKGDAV-KQYNXXCUSA-N

InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C10H13N4O8P
Molecular Weight	348.206
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
A clinical grade poly I:C-analogue (Ampligen) promotes optimal DC maturation and Th1-type T cell responses of healthy donors and cancer patients in vitro.	2009-01-01	18977262
Multiple receptor systems for glutamate detection in the taste organ.	2008-10	18827337
Predicting the sensitivity and specificity of published real-time PCR assays.	2008-09-25	18817537
Identification and characterization of two trypanosome TFIIS proteins exhibiting particular domain architectures and differential nuclear localizations.	2008-09	18627464
Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3.	2008-09	18550257
Effects of dietary inosinic acid on carcass characteristics, meat quality, and deposition of inosinic acid in broilers.	2008-07	18577617
Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes.	2008-07	18557814
Expression of caffeine biosynthesis genes in tea (Camellia sinensis).	2008-06-07	18533472
Estimation of genetic parameters for contents of intramuscular fat and inosine-5'-monophosphate and carcass traits in Chinese Beijing-You chickens.	2008-06	18492997
C3H/HeN mouse model for the evaluation of antiviral agents for the treatment of Venezuelan equine encephalitis virus infection.	2008-06	18313150
The plasma ammonia response to cycle exercise in COPD.	2008-04	18094007
Kinetic studies on the reactions of [Pd(dach)(X-Y)] complexes with some DNA constituents.	2008-02-14	18239837
Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis.	2008-01	18215774
IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations.	2008-01	17662091
The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation.	2008	18644147
Cross-protection against H5N1 influenza virus infection is afforded by intranasal inoculation with seasonal trivalent inactivated influenza vaccine.	2007-11-01	17922395
A motif-based search in bacterial genomes identifies the ortholog of the small RNA Yfr1 in all lineages of cyanobacteria.	2007-10-17	17941988
Characterization of retinal inosine monophosphate dehydrogenase 1 in several mammalian species.	2007-10-03	17960124
IMPDH1 promoter mutations in a patient exhibiting azathioprine resistance.	2007-10	17001353
Intranasal immunization with H5N1 vaccine plus Poly I:Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge.	2007-09	17890128
Formamide as the main building block in the origin of nucleic acids.	2007-08-16	17767725
Sources of umami taste in Cheddar and Swiss cheeses.	2007-08	17995691
Correlation between breakdown of the blood-brain barrier and disease outcome of viral encephalitis in mice.	2007-08	17223204
Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).	2007-07-26	17585753
Oxidation of chylomicron remnant-like particles inhibits their uptake by THP-1 macrophages by apolipoprotein E-dependent processes.	2007-07	17540618
Pathway aberrations of murine melanoma cells observed in Paired-End diTag transcriptomes.	2007-06-26	17594473
TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules.	2007-04-15	17404303
Effect of exogenous interferon and an interferon inducer on western equine encephalitis virus disease in a hamster model.	2007-04-10	17118420
Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor.	2007-02-01	17005341
Why do mutations in the ubiquitously expressed housekeeping gene IMPDH1 cause retina-specific photoreceptor degeneration?	2006-09	16936083
Detection of eight antibodies in cancer patients' sera against proteins derived from the adenocarcinoma A549 cell line using proteomics-based analysis.	2006-06-21	16707281
Structure of SAICAR synthase from Thermotoga maritima at 2.2 angstroms reveals an unusual covalent dimer.	2006-04-01	16582479
The nucleotide derivatives inosine and inosinic acid inhibit intestinal absorption of mizoribine in rats.	2006-02-15	16438959
Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice.	2006	17176632
Creatine supplementation reduces muscle inosine monophosphate during endurance exercise in humans.	2005-12	16331129
Competitive reactions of L-methionine and 5'-GMP towards platinum (II) complexes.	2005-11	16787339
[Genetic parameter estimation for inosine-5-monophosphate and intramuscular fat contents and other meat quality traits in chicken muscle].	2005-11	16378936
Mechanisms of action of mycophenolate mofetil in preventing acute and chronic allograft rejection.	2005-10-15	16251851
Indications of mycophenolate mofetil in liver transplantation.	2005-09-27	16286893
Stoichiometric estimates of the biochemical conversion efficiencies in tsetse metabolism.	2005-08-05	16083496
Polyinosinic acid induces TNF and NO production as well as NF-kappaB and AP-1 transcriptional activation in the monocytemacrophage cell line RAW 264.7.	2005-08	16158333
Study of the reactions between platinum(II) complexes and L-methionine in the presence and absence of 5'-GMP.	2005-07	15927265
Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus.	2005-06	15911031
Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition.	2005-05-09	15882454
Guanylic nucleotide starvation affects Saccharomyces cerevisiae mother-daughter separation and may be a signal for entry into quiescence.	2005-05-04	15869715
Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes.	2005-03-18	15774020
Interferon: ten stories in one. A short review of some of the highlights in the history of an almost quinquagenarian.	2005	16400870
Mechanisms of action of mycophenolate mofetil.	2005	15803924
Ageing and immunosuppression in kidney transplantation.	2004-12	15859933
Acid phosphatase/phosphotransferases from enteric bacteria.	2001	16233057

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:30:59 GMT 2025` Edited by `admin` on `Mon Mar 31 20:30:59 GMT 2025`
Record UNII	TAO7US05G5
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

INOSINIC ACID

Common Name

English

CYTOSINE INOSINATE

Preferred Name

English

INOSINIC ACID [MI]

Common Name

English

INOSINIC ACID, 5'-

Common Name

English

IMP

Common Name

English

HYPOXANTHINE RIBOSIDE-5-PHOSPHORIC ACID

Common Name

English

Cytosine inosinate [WHO-DD]

Common Name

English

INOSINE 5'-(DIHYDROGEN PHOSPHATE)

Systematic Name

English

E-630

Code

English

INOSINE PHOSPHATE

Common Name

English

5'-IMP

Common Name

English

INS NO.630

Code

English

INS-630

Code

English

INOSINE-5'-MONOPHOSPHORIC ACID

Common Name

English

5'-INOSINIC ACID

Systematic Name

English

Classification Tree Code System Code

CODEX ALIMENTARIUS (GSFA)

INS-630