Bifepramide, (+)- belong to the class of parasympatholytic agents that reduce the activity of the parasympathetic nervous system.

ISOMOLPAN is a selective D3/D2 receptor agonist.

Ibazocine is an analgesic that has never been marketed.

Solypertine (WIN-18413-2) is an antiadrenergic drug. Solypertine selectively blocked the conditioned avoidance response in rats. Solypertine potentiated hexobarbitone sleeping time, caused hypothermia and afforded protection from amphetamine toxicity inaggregated mice.

Carbenzide is hydrazine derivative with the high antidepressant activity and low toxicity patented by pharmaceutical company Warner-Lambert Pharmaceutical Co. Carbenzide acts via monoamine oxidase (MAO) inhibition and increase the level of brain serotonin.

Eproxindine (KC 3791) is an antiarrythmic. It is able to inactivate voltage-dependent sodium channels. Eproxindine also proved to be capable of blocking open potassium channels at outwardly directed potassium currents

Lodaxaprine is a chemically original compound which possesses the pharmacological properties of a potent, p.o. active anticonvulsant. In mice, lodaxaprine antagonized electroconvulsive shock and chemically induced seizures with an overall potency comparable to that of carbamazepine. In naturally photosensitive Senegalese Papio-papio baboons lodaxaprine antagonized myoclonus and cortical paroxysmal discharges. In this model lodaxaprine was approximately one-fourth as potent as phenobarbital, twice as potent as carbamazepine and 6 times more potent than sodium valproate. Lodaxaprine had been in phase II clinical trial for the treatment of epilepsy. However, this development was discontinued.

Mobenzoxamine is gastro-intestinal function modulator, that enhanced gastric emptying. In preclinical models clathrate compound of mobenzoxamine with beta-cyclodextrin showed a clear amelioration of the delayed gastric emptying induced by Barium chloride. On isolated guinea pig ileum, Mobenzoxamine inhibited contractions induced by various agonists equally to or more potently than trimebutine or papaverine.

Exepanol (KC 2450), a benzoxepine derivative, is a gastrokinetic. It facilitated the peristaltic reflex. Exepanol enhances resting pressure of the lower esophageal sphincter.