EXEPANOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H15NO2
Molecular Weight	193.2423
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN[C@@H]1COC2=C(C=CC=C2)[C@H](O)C1

InChI

InChIKey=JWUPWOYNGNTOKD-WCBMZHEXSA-N

InChI=1S/C11H15NO2/c1-12-8-6-10(13)9-4-2-3-5-11(9)14-7-8/h2-5,8,10,12-13H,6-7H2,1H3/t8-,10+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8876943 | https://www.ncbi.nlm.nih.gov/pubmed/4039143 | https://www.ncbi.nlm.nih.gov/pubmed/3691640

Exepanol (KC 2450), a benzoxepine derivative, is a gastrokinetic. It facilitated the peristaltic reflex. Exepanol enhances resting pressure of the lower esophageal sphincter.

Approval Year

PubMed

Title	Date	PubMed
Effects of exepanol-HCl, metoclopramide and domperidone on the lower esophageal sphincter of dogs.	1985	4039143
Effects of KC 2450 on the lower esophageal sphincter in vivo and in vitro.	1987 Oct 13	3691640
Role of nitric oxide in gastrokinetic effects of the new benzoxepine derivative exepanol hydrochloride.	1996 Sep	8876943

Patents

Name

Type

Language

EXEPANOL

Official Name

English

exepanol [INN]

Common Name

English

(±)-CIS-2,3,4,5-TETRAHYDRO-3-(METHYLAMINO)-1-BENZOXEPIN-5-OL

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66880