EXEPANOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H15NO2
Molecular Weight	193.2423
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN[C@@H]1COC2=C(C=CC=C2)[C@H](O)C1

InChI

InChIKey=JWUPWOYNGNTOKD-WCBMZHEXSA-N

InChI=1S/C11H15NO2/c1-12-8-6-10(13)9-4-2-3-5-11(9)14-7-8/h2-5,8,10,12-13H,6-7H2,1H3/t8-,10+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C11H15NO2
Molecular Weight	193.2423
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8876943 | https://www.ncbi.nlm.nih.gov/pubmed/4039143 | https://www.ncbi.nlm.nih.gov/pubmed/3691640

Exepanol (KC 2450), a benzoxepine derivative, is a gastrokinetic. It facilitated the peristaltic reflex. Exepanol enhances resting pressure of the lower esophageal sphincter.

Approval Year

PubMed

Title	Date	PubMed
Role of nitric oxide in gastrokinetic effects of the new benzoxepine derivative exepanol hydrochloride.	1996-09	8876943
Effects of KC 2450 on the lower esophageal sphincter in vivo and in vitro.	1987-10-13	3691640
Effects of exepanol-HCl, metoclopramide and domperidone on the lower esophageal sphincter of dogs.	1985	4039143

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:44:17 GMT 2025` Edited by `admin` on `Mon Mar 31 18:44:17 GMT 2025`
Record UNII	5CF9F84B3A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EXEPANOL

Official Name

English

exepanol [INN]

Preferred Name

English

(±)-CIS-2,3,4,5-TETRAHYDRO-3-(METHYLAMINO)-1-BENZOXEPIN-5-OL

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66880