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Details

Stereochemistry RACEMIC
Molecular Formula C15H21NO2
Molecular Weight 247.3327
Optical Activity ( + / - )
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ISOMOLPAN

SMILES

CCCN1CCC[C@@H]2[C@@H]1COC3=CC=C(O)C=C23

InChI

InChIKey=GSLWRDKYYIQKIM-JSGCOSHPSA-N
InChI=1S/C15H21NO2/c1-2-7-16-8-3-4-12-13-9-11(17)5-6-15(13)18-10-14(12)16/h5-6,9,12,14,17H,2-4,7-8,10H2,1H3/t12-,14-/m0/s1

HIDE SMILES / InChI
ISOMOLPAN is a selective D3/D2 receptor agonist.

CNS Activity

Curator's Comment: Known to be CNS active in rat. Human data not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
Discriminative stimulus properties of the dopamine D3 receptor agonists, PD128,907 and 7-OH-DPAT: a comparative characterization with novel ligands at D3 versus D2 receptors.
2000-02-14
Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release.
1998-05
Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: II. Both D2 and "silent" D3 autoreceptors control synthesis and release in mesolimbic, mesocortical and nigrostriatal pathways.
1995-11
Modulation of in vivo dopamine release by D2 but not D1 receptor agonists and antagonists.
1987-03
Patents
Name Type Language
Isomolpan [WHO-DD]
Preferred Name English
ISOMOLPAN
INN   WHO-DD  
INN  
Official Name English
isomolpan [INN]
Common Name English
Code System Code Type Description
FDA UNII
I06LXQ54TY
Created by admin on Mon Mar 31 19:32:40 GMT 2025 , Edited by admin on Mon Mar 31 19:32:40 GMT 2025
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INN
6893
Created by admin on Mon Mar 31 19:32:40 GMT 2025 , Edited by admin on Mon Mar 31 19:32:40 GMT 2025
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NCI_THESAURUS
C170082
Created by admin on Mon Mar 31 19:32:40 GMT 2025 , Edited by admin on Mon Mar 31 19:32:40 GMT 2025
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EVMPD
SUB08325MIG
Created by admin on Mon Mar 31 19:32:40 GMT 2025 , Edited by admin on Mon Mar 31 19:32:40 GMT 2025
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EPA CompTox
DTXSID40148016
Created by admin on Mon Mar 31 19:32:40 GMT 2025 , Edited by admin on Mon Mar 31 19:32:40 GMT 2025
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PUBCHEM
65899
Created by admin on Mon Mar 31 19:32:40 GMT 2025 , Edited by admin on Mon Mar 31 19:32:40 GMT 2025
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ChEMBL
CHEMBL2220428
Created by admin on Mon Mar 31 19:32:40 GMT 2025 , Edited by admin on Mon Mar 31 19:32:40 GMT 2025
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CAS
107320-86-5
Created by admin on Mon Mar 31 19:32:40 GMT 2025 , Edited by admin on Mon Mar 31 19:32:40 GMT 2025
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SMS_ID
100000082832
Created by admin on Mon Mar 31 19:32:40 GMT 2025 , Edited by admin on Mon Mar 31 19:32:40 GMT 2025
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