MOBENZOXAMINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C30H35FN2O3
Molecular Weight	490.6089
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)C(OCCN2CCN(CCCC(=O)C3=CC=C(F)C=C3)CC2)C4=CC=CC=C4

InChI

InChIKey=DFNYDADZMXPPLY-UHFFFAOYSA-N

InChI=1S/C30H35FN2O3/c1-35-28-15-11-26(12-16-28)30(25-6-3-2-4-7-25)36-23-22-33-20-18-32(19-21-33)17-5-8-29(34)24-9-13-27(31)14-10-24/h2-4,6-7,9-16,30H,5,8,17-23H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3243512

Mobenzoxamine is gastro-intestinal function modulator, that enhanced gastric emptying. In preclinical models clathrate compound of mobenzoxamine with beta-cyclodextrin showed a clear amelioration of the delayed gastric emptying induced by Barium chloride. On isolated guinea pig ileum, Mobenzoxamine inhibited contractions induced by various agonists equally to or more potently than trimebutine or papaverine.

Originator

Approval Year

PubMed

Title	Date	PubMed
[Pharmacological studies on the clathrate compound of mobenzoxamine with beta-cyclodextrin. (I). Effects on the digestive system].	1988 Nov	3243512

Patents

Name

Type

Language

MOBENZOXAMINE

Official Name

English

mobenzoxamine [INN]

Common Name

English

4'-FLUORO-4-(4-(2-((P-METHOXY-.ALPHA.-PHENYLBENZYL)OXY)ETHYL)-1-PIPERAZINYL)BUTYROPHENONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29698