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Details

Stereochemistry ACHIRAL
Molecular Formula C22H25N3O3
Molecular Weight 379.4522
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SOLYPERTINE

SMILES

COC1=C(C=CC=C1)N2CCN(CCC3=CNC4=CC5=C(OCO5)C=C34)CC2

InChI

InChIKey=GIWODWVYEOAGQV-UHFFFAOYSA-N
InChI=1S/C22H25N3O3/c1-26-20-5-3-2-4-19(20)25-10-8-24(9-11-25)7-6-16-14-23-18-13-22-21(12-17(16)18)27-15-28-22/h2-5,12-14,23H,6-11,15H2,1H3

HIDE SMILES / InChI
Solypertine (WIN-18413-2) is an antiadrenergic drug. Solypertine selectively blocked the conditioned avoidance response in rats. Solypertine potentiated hexobarbitone sleeping time, caused hypothermia and afforded protection from amphetamine toxicity inaggregated mice.

CNS Activity

Curator's Comment: Solypertine selectively blocked the conditioned avoidance response in rats. Solypertine potentiated hexobarbitone sleeping time, caused hypothermia and afforded protection from amphetamine toxicity inaggregated mice.

Approval Year

PubMed

PubMed

TitleDatePubMed
Pyscho-sedative properties of three indolyl-ethyl-piperazine derivatives.
1966 Jan
Patents

Sample Use Guides

Mice: LD50 = 81.5 mg/kg. Solypertine (WIN-18413-2) in doses of 4 and 8 mg/kg, caused behavioural depression and apathy in the cats.
Route of Administration: Intraperitoneal
Name Type Language
SOLYPERTINE
INN  
INN  
Official Name English
solypertine [INN]
Common Name English
5H-1,3-DIOXOLO(4,5-F)INDOLE, 7-(2-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-
Systematic Name English
7-(2-(4-(O-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-5H-1,3-DIOXOLO(4,5-F)INDOLE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C66883
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
NCI_THESAURUS C29710
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
Code System Code Type Description
FDA UNII
9BUF6DCO0C
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
PUBCHEM
20517
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
EPA CompTox
DTXSID50196189
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
SMS_ID
100000084044
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
EVMPD
SUB10577MIG
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
ChEMBL
CHEMBL1739674
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
CAS
4448-96-8
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
NCI_THESAURUS
C152390
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
INN
1327
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY