U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1771 - 1780 of 8583 results

Tubocurarine, a naturally occurring alkaloid, is used to treat smoking withdrawl syndrom. Tubocurarine, the chief alkaloid in tobacco products, binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Two types of central nervous system effects are believed to be the basis of Tubocurarine's positively reinforcing properties. A stimulating effect is exerted mainly in the cortex via the locus ceruleus and a reward effect is exerted in the limbic system. At low doses the stimulant effects predominate while at high doses the reward effects predominate. Intermittent intravenous administration of Tubocurarine activates neurohormonal pathways, releasing acetylcholine, norepinephrine, dopamine, serotonin, vasopressin, beta-endorphin, growth hormone, and ACTH. Tubocurarine competes with acetylcholine for post-synaptic nicotinic NM receptors and blocks them.
Nitrofurazone is used to treat burns that have become infected. It is also used to treat skin infections due to skin grafts. It works by killing bacteria or preventing their growth. The exact mechanism of action is unknown. Nitrofurazone inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. The severe or irreversible adverse effects of Nitrofurazone, which give rise to further complications include Peripheral neuropathy, Thromboembolic disorder.
Status:
US Previously Marketed
First approved in 1945
Source:
Methionine by Various Mfrs.
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Methionine is an non-polar, aliphatic, essential α-amino acid that is used in the biosynthesis of proteins. High levels of methionine can be found in eggs, sesame seeds, Brazil nuts, fish, meats and some other plant seeds; methionine is also found in cereal grains. Most fruits and vegetables contain very little of it. Most legumes are also low in methionine. However, it is the combination of methionine and cystine which is considered for completeness of a protein. There is scientific evidence that restricting methionine consumption can increase lifespans in some animals. However, since methionine is an essential amino acid, it cannot be entirely removed from animals' diets without disease or death occurring over time. For example, rats fed a diet without methionine developed steatohepatitis (fatty liver), anemia and lost two thirds of their body weight over 5 weeks. Administration of methionine ameliorated the pathological consequences of methionine deprivation.
Status:
US Previously Marketed
Source:
LAURON 50MG/CC by ENDO
(1961)
Source URL:
First approved in 1945
Source:
Lauron by Endo
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


AUROTHIOGLYCANIDE is a gold compound used in the management of rheumatoid arthritis. The mechanism of its action remains unknown.
Status:
US Previously Marketed
Source:
Chotbyn clihydrogen cit. by Flint
(1945)
Source URL:
First approved in 1945
Source:
Chotbyn clihydrogen cit. by Flint
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


TRICHOLINE CITRATE is indicated for the treatment and management of hepatic disorders and asthma symptoms in adults. It exerts lipotropic action in the hepatic cells. It also can lower the symptoms of asthma and reducing the pro-inflammatory and inflammatory mediators of the leukotriene pathway.
Status:
US Previously Marketed
Source:
Furmethide by Smith Kline & French
(1944)
Source URL:
First approved in 1944
Source:
Furmethide by Smith Kline & French
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.
Status:
US Previously Marketed
First approved in 1944

Class (Stereo):
CHEMICAL (ACHIRAL)


Aminohippurate (p-aminohippuric acid, PAH, PAHA) is the glycine amide of p-aminobenzoic acid. Aminohippuric acid sodium salt is an agent to measure effective renal plasma flow (ERPF).
Dicumarol is an coumarin-like compound found in sweet clover. It is used as oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X). It results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots. Dicumarol is also used in biochemical experiments as an inhibitor of reductases.
Status:
US Previously Marketed
Source:
Carbarsone by Lilly
(1944)
Source URL:
First approved in 1944
Source:
Carbarsone by Lilly
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Carbarsone is an antiambeic, antihistomonal drug effective in controlling and preventing blackhead disease in turkeys (a disease caused by a protozoan parasite Histomonas meleagridis). Carbarsone was approved by FDA, however, it has not been marketed in the USA scince 1996.
Status:
US Previously Marketed
Source:
STRASCOGESIC SALICYLAMIDE by STRASENBURGH
(1961)
Source URL:
First approved in 1943
Source:
Salicylamide by Various Mfrs.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Salicylamide is a non-prescription drug with analgesic and antipyretic properties (NSAID). It is used in combination with aspirin and caffeine in the over-the-counter pain remedies (such as EXAPRIN). Salicylamide can produce sedation and sleep in humans and animals. Has been used as model drug in pharmacokinetic and metabolic studies as a dophamine 2 receptor ligand. Salicylamide is a white or light pink crystals or powder. Organic compound it is a carboxamide derivative of salicylic acid.

Showing 1771 - 1780 of 8583 results