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Details

Stereochemistry ACHIRAL
Molecular Formula C9H10N2O3
Molecular Weight 194.1873
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMINOHIPPURIC ACID

SMILES

NC1=CC=C(C=C1)C(=O)NCC(O)=O

InChI

InChIKey=HSMNQINEKMPTIC-UHFFFAOYSA-N
InChI=1S/C9H10N2O3/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13/h1-4H,5,10H2,(H,11,14)(H,12,13)

HIDE SMILES / InChI

Description

Aminohippurate (p-aminohippuric acid, PAH, PAHA) is the glycine amide of p-aminobenzoic acid. Aminohippuric acid sodium salt is an agent to measure effective renal plasma flow (ERPF).

CNS Activity

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
AMINOHIPPURATE SODIUM

Cmax

ValueDoseCo-administeredAnalytePopulation
250 μg/mL
30 mg/kg single, intravenous
AMINOHIPPURIC ACID plasma
Rattus norvegicus

AUC

ValueDoseCo-administeredAnalytePopulation
880 μg × min/mL
30 mg/kg single, intravenous
AMINOHIPPURIC ACID plasma
Rattus norvegicus

T1/2

ValueDoseCo-administeredAnalytePopulation
5.67 min
30 mg/kg single, intravenous
AMINOHIPPURIC ACID plasma
Rattus norvegicus

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer







Drug as perpetrator​

Drug as victim

PubMed

Sample Use Guides

In Vivo Use Guide
6 to 10 mg/kg
Route of Administration: Intravenous
In Vitro Use Guide
The hOAT1-transformed cells were incubated in 200 ml of Dulbecco's PBS containing 5 mM D-glucose, 10 uM D-[3H]-mannitol and 10 uM [14C]-aminohippuric acid, for 10 min at room temperature.